Phenethylamines 2,4-dimethoxyamphetamine - some short info

[ralf2]

Hi all,
I usually don't like disclosing effects of obscure drugs in case some asshole starts to sell it and make it illegal. But in this case I hope this drug is not potent enough to sell.

Maybe you have read the entry for 2,4-DMA in PIHKAL. It's only tested up to 60mg with some inconclusive results.

I have tried it at higher doses and thought I would share the results for science.

At 100 and 150mg you get this weird feeling that is hard to categorize, for sure it is trippy but hard to put your finger on it. Like taking a small step away from reality.
But at 200mg you can recognize that it is like a classic psychedelic. Closing my eyes I could see faint geometric patterns. But the mind trip is stronger than the visuals. Somehow it reminded me of a lower dose of DOM. In that you are tripping for sure, but not so much visuals.
Half way through the trip my partner came over unexpectedly. It was nice to have her with me and it wasn't that hard to act normal. Sex was nice even though it was a bit difficult to get hard.

I took it at around 16:30 and by the time I went to bed at 23-00 something it was into afterglow territory. But it was still a bit tricky to get to sleep, but it was possible eventually.

Overall I think it is pretty nice. Especially at the lower doses I liked just taking a bicycle ride around the neighborhood in the summer evening. I don't have any more now, but it would have been interesting to see how it develops at higher doses.

I think this must be one of the simplest psychedelic molecules which is interesting to me.

 

[xdrc]

Thanks for your service! How is the bodyload, anything to be weary of?

 

[Allylbenzene]

Very cool.

I hope this drug is not potent enough to sell

I think in some ways potency is overrated. It's ideal for research purposes but shouldn't serve as a "benchmark" for therapeutic/recreational drug design.

I think the image below gives some (2D) context for what you reported; comparing DOM and 5-desmethoxy-DOM to tryptamines with 5-HT2A activity.

Top row:
• 5-MeO-DMT / 7-Me-5-MeO-DMT / 7-Me-αMT
Bottom row:
• DOM / 5-desmethoxy-DOM

I think this must be one of the simplest psychedelic molecules which is interesting to me.

If someone made the α-ethyl of 2,4-DMA that could be interesting. Likewise the α-ethyl of TMA-2 aka 4C-O.

 

[xdrc]

Your structures are wrong Allylbenzene, 2,4-DMA is the 2,4-dimethoxy compound, i.e. methoxy not methyl in the para position.

 

[Allylbenzene]

Thanks, the labels were incorrect...fixed.

Afaik pre-1990 literature doesn't fully investigate 7-MeO-tryptamine ... but having just looked it up, PubChem lists this 2014 paper:

Alpha-ethyltryptamines as dual dopamine-serotonin releasers

The dopamine (DA), serotonin (5-HT), and norepinephrine (NE) transporter releasing activity and serotonin-2A (5-HT2A) receptor agonist activity of a series of substituted tryptamines are reported. Three compounds, 7b, (+)-7d and 7f, were found to be potent dual DA/5-HT releasers and were >10-fold less potent as NE releasers. Additionally, these compounds had different activity profiles at the 5-HT2A receptor. The unique combination of dual DA/5-HT releasing activity and 5-HT2A receptor activity suggests that these compounds could represent a new class of neurotransmitter releasers with therapeutic potential. https://doi.org/10.1016/j.bmcl.2014.07.062

#1 = PAL-287 (1-naphthyl-2-aminopropane)
PAL-287 was found to induce transporter mediated release of DA, 5-HT, NE with EC50 values of 12.6 nM, 3.4 nM, 11.1 nM respectively.