1-benzoylpiperazine

[wungchow]

Methinks this could be an interesting compound with improved potency over BZP. I figure the amide group is roughly bioisosteric with the benzoyl ester group in cocaine. Any thoughts?

 

[Pomzazed]

and more prone to hydrolysis?

 

[wungchow]

^the amide group should be fairly stable as it is a tertiary nitrogen and bonded directly to a phenyl group.

 

[dread]

2-benzoylpiperazine would be interesting too.. it'd actually be a phenethylamine with a b-ketone.

 

[hugo24]

Its inactive per one paper I have read.

 

[MurphyClox]

Which? Could you provide journal name, volume, 1st page plz? Thanks!

 

[hugo24]

My bad I can't find the paper anymore,I throwed things away recently to lighten up on my papers,those about inactive compounds went with it,sorry.But I'm sure I had one paper taking up the SAR of benzylpiperazines and exploring if its benzoylanalogs are also active,well,they weren't.Was it a Glennon paper?

 

[Hammilton]

my search brought me to this- it's interesting, but not really relevant.