OK so my buddy has had a history of seizures he believes to have originated when he was working with and huffing Medical Nitrous oxide
(5- 100 lb tanks) for about 3 years ...resulting in a horrible B-12 deficiency, At 17 he was of Diagnosed with Polly-Neuropathy affecting mainly his extremities and HPPD (The nerve damage resulted in Gran-Mal seizures and extreme lack of coordination ....Imagine that!). He is now 23 and although his muscle strength and coordination have come back to almost 100% there have been at least 10 seizures all very spaced out over this 6 year period and had stopped using NOS completely after that diagnosis. he has been prescribed Keppra and Depakote neither having much success. Mind you he has been a poly-user of any and all narcotics kicked off by marijuana at 13 (daily since) and becoming serious at around 15 using and and all Narcotics. (Any and all pills, mainly Benzos and opiates/opiods, Cocaine/ketamine and of course copious amounts of LSD/DMT).
Just a few weeks ago he went in for a regular physical and was prescribed Lexapro for anxiety which he refused after informing his Dr. of the dangerous and lethal interactions between SSRI's his recreational habits, he ended up walking out with Buspirone 5mg 2 time a day. Now my buddy's an odd guy he goes through stages binging on certain drugs and directly after leaving the Dr he ends up smoking meth. This snowballed into a binder pretty much daily meth use for a few weeks, typically less than a half gram a day sometimes with a little crack as well followed by GHB or Ketamine (IM) a lot of times Xanax is combined with the Ketamine. His most recent seizure was in this time period while he was alone, and did not realize he had one until he was getting ready for work and realized he had a huge knot on his head/stiff muscles and a sliced tongue. He had taken the Buspirone but had also taken a 5-HTP with his daily vitamins D and B-12. He has continued the Buspirone but has dropped 5-HTP since.
I apologize if i gave to much backstory! This is just obviously scary stuff! My friend in all his brilliance believes it to be a specific interaction between the Buspirone and the 5-HTP both affecting Serotonin. Personally i'm starting to think that mabye juuuuuustttt maaaabyeee smoking Meth and crack, popping Xanax/shooting Ketamine might have something to do with it as well...figured id come to ask the home team what you all think? I'm thinking that hes just got wayyyy to much going on with his serotonin levels, possibly even serotonin syndrome...Idk its quite the cocktail, hes always used drugs like this and he is very aware he has a substance abuse problem and a great support group he just currently wont for whatever reason utilize . We are really just wanting to know more about the interactions between any of the substances mentioned along with any advice or aspects we might have overlooked!
The biggest scariest is thing They never occur under the influence but they also Don't often occur around the time after heavy abuse has abruptly stopped. There are no "Auras" or signs that he can notice before he drops....he has no recollection of what happens before or after the Seizure.Ii have witnessed a few of them as has his Girl friend and coworkers and cops/EMT and he sometimes says or does strange things directly beforehand and he always come to very confused,weak and disoriented. He will fall and hit his head, has totaled a car, bites his tongue wide open every time. Its all just extremely taxing both psychically and mentally! Obviously abstinence from the narcotics would be his best chance of reducing the seizures, but we are more interested in whats known about interactions between these narcotics and prescription drugs! Thank you all in advance for any information!!!
Blesss
