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Tryptamines L. asiatica - lilliputian hallucinations

Perhaps it's simply a language barrier graced with pedantry?
Pardon me if I'm wrong, but isn't English your first language? Regardless, the pedantry is very important here, and I'm going to engage in more of it because it matters a lot when handling stereotypes.

You cited Scientism here as if to imply that scientists are necessarily followers of Scientism. Yes, many scientists to embrace Scientism, but a great many do not. I have studied in academia, and there I have encountered quite a diverse set of people who practice science and are therefore scientists. Some of them were deeply religious even and absolutely held mystical beliefs rooted in their religions. Practicing science does not equate to believing in Scientism. Absolutely no way!
Indigenous cultures tend to hold knowledge of things which academia remains ignorant. Whether I use the term molecular biochemist or academic, this refers to followers of modern science. These followers will tend to defend their belief system.
Lol, the world is a lot bigger than you seem to realize. Is bluelight an academic resource? Or are we all "indigenous herbalist types" here? :ROFLMAO: What you perceive to be unnecessary pedantry is actually essential to recognizing and escaping your stereotypes. These stereotypes may help you deal with the world on simpler terms, but they also confine you to an overly narrow frame and limit your opportunities for increased understanding and growth.
 
You cited Scientism here as if to imply that scientists are necessarily followers of Scientism. Yes, many scientists do embrace Scientism, but a great many do not.
I was implying that they tend to abide by the scientific method which emphasizes empirical evidence & repeatable experiments. This often goes hand-in-hand with a materialist version of reality (and its associated limitations) but not always.

In this case we have Colin Domnauer, PhD investigating the bolete hallucinations. Will he succeed in deciphering their intangible aspects and understand their nonlocal origin? It's always a possibility. Alternatively will reductionism point to certain signalling mechanisms? What would Shulgin say?

Pardon me if I'm wrong, but isn't English your first language?
It is.

Is bluelight an academic resource? Or are we all "indigenous herbalist types" here?
No, but people with an academic-mindset seem present on bluelight. No doubt some are purely materialist but I'm sure others are not, and these are likely to appreciate the limitations of the scientific method whilst still seeing value in it.
 
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Pardon my interjection, but cannot more than one epistemological methods have a seat at the table focused on better understanding psychedelics (or drugs in general - or better yet, most everything)? Positivism can be reductionist and traditional indigenous modes of knowledge production can be quite non-empirical. Together, however at odds they seem, I'd wager that they can both help shed light on the immensely complex mechanisms of psychedelics writ large.

Also some people seem to be drawn more to one or one type of epistemology than others...if anything those differences should encourage their respectively different adoptees to come together in good faith to better understand the object of their shared confusion.
 
Positivism can be reductionist and traditional indigenous modes of knowledge production can be quite non-empirical. Together, however at odds they seem, I'd wager that they can both help shed light on the immensely complex mechanisms of psychedelics writ large.
I don't buy this characterization of competing epistomologies nor do I buy the notion that science and indigenous knowledge respectively arise neatly from these two seemingly exclusive epistomologies. That's frankly bullshit.

I'm also rather offended by this notion that indigenous knowledge is "non-empirical". Maybe some indigenous "healers" ignore empirical evidence, and I guess the same could be said by many New Age "spiritual" practitioners of various types in Western culture---and at least some licensed and practicing doctors for that matter. I think we can universally refer to such people as quacks or hucksters, and we can recognize that their existence spans across cultures.

I am also very uncomfortable with the attempted classification of any indigenous knowledge into the "spiritual" category, in so far as the matter versus spirit duality is also a Western construction. IMO, the real problem here is an inability to describe and communicate complex phenomenon without a shared cultural context. This gets reinforced by colonial interactions, in which the colonizers have incentive to discredit the indigenous knowledge or alternatively to exotify it. (Again, the New Age movement comes to mind!)

The problem in this thread and with this mushroom story is not that some stingy "scientists" are refusing to accept the "non-empirical knowledge" of the "indigenous", but rather that we---the readers---simply don't have information to go on. Most of the reporting is speculative, and the actual facts that have been presented are quite thin. We don't have even one proper first-hand trip report, do we? Why not? I can think of a few possible reasons. It's certainly possible that the field is simply wide open. Colin Domnauer is a biologist and is not likely to give attention to traditional use, or whatever. Maybe someday another researcher will take up that cause and we will be able to learn more.

For a number of reasons, however, I doubt that there is much of anything to study "there". The mushroom could be a hoax or maybe something akin to a ghost story among the locals (which could be motivated by any number of underlying things). Either of these might be interesting to study, but my best guess is that the mushroom simply produces a really shitty trip. Maybe people come out totally amnesic? Or maybe it's just super-toxic---presumably nastier than Solanaceae plants (like Datura) which many people around the world do find reason to use.

If the trip is really shitty, then why would anyone "indigenous" or otherwise want to take the drug? Probably only the unusually naive and overly curious. I dunno how many of you have interacted with Chinese people or Asian cultures in general, but often if they are all laughing in your presence, they are laughing at you. Anyone going to a market and asking specifically about mushrooms that cause a shitty trip is probably going to be laughed at for being ignorant/foolish, like defiant children ignoring their elder's advice who are about to suffer the consequences.
 
...cannot more than one epistemological methods have a seat at the table focused on better understanding psychedelics (or drugs in general - or better yet, most everything)? ...traditional indigenous modes of knowledge production can be quite non-empirical.
I'd agree. A key limitation of modern academia is its inability to quantify (let alone acknowledge) the intangible landscape, meanwhile it's a common feature for many indigenous cultures. They may not have a GCMS machine but their abilities are equally relevant and in some ways out-compete modern science.

An academic researcher doesn't understand the therapeutic applications of a botanical without a GCMS, but the indigenous merely asks. This perfectly encapsulates the rudimentary undertones of modern academia.

For a number of reasons, however, I doubt that there is much of anything to study "there". The mushroom could be a hoax or maybe something akin to a ghost story among the locals (which could be motivated by any number of underlying things).
I think you're over-compensating and swerving into oncoming traffic. This "hoax" would have to span continents (Papua New Guinea, Yunnan, and the Philippines) and somehow establish the widespread use of the name "Xiao ren ren".

Xiao Ren Ren: The “Little People” of Yunnan (2008)

Xiao ren ren are widely known in Yunnan province, China. The phrase means “little men”or “little people” (xiao, little; ren, man or person, the redundancy being an idiom to indicate lots of men or people, which the standard plural form renmen does not necessarily connote). Xiao ren ren are typically glimpsed or experienced after dining on inadvertently undercooked, blue-staining boletes of uncertain identity. The people of Yunnan seem almost universally amused by the xiao ren ren rather than fearing them or revering them.

I have since met more than a dozen people in Yunnan who have personally seen the xiao ren ren, including one woman whose visual experience, though pleasant, was accompanied by nausea and vomiting. The two first-hand accounts below were unusual in that they were related to me in English. (source)

Even the original academics who investigated it in Papua New Guinea in 1940s assumed it was a hoax, as did the more recent academic to visit China, the mycologist Gordon Wasson.

Does your hoax/conspiracy have a motive?

The problem in this thread and with this mushroom story is not that some stingy "scientists" are refusing to accept the "non-empirical knowledge" of the "indigenous"
I don't think its reasonable to expect an academic researcher to ask Lanmaoa asiatica by what mechanism does its psychoactivity originate.

Either of these might be interesting to study, but my best guess is that the mushroom simply produces a really shitty trip.
Your "best guess" can be verified by looking at hospital reports from the literature.

From a 2023 paper:
A total of 398 patients with acute Lanmaoa asiatica poisoning admitted to the emergency department of the Affiliated Hospital of Yunnan University from January 2020 to December 2021 were selected as the study objects.
...
The poisoning of Lanmaoa asiatica is mainly neuropsychiatric type 12-24 hours (82.51%), and the main symptoms are hallucinations (90.70%), delirium (35.18%), dizziness (30.65%) and mania (9.05%).
Analysis of epidemiology and clinical characteristics of Lanmaoa asiatica poisoning
J Clin Emerg, 2023
doi: 10.13201/j.issn.1009-5918.2023.05.007

From a 2024 paper:
Mushroom poisoning demonstrates distinct regional and seasonal patterns. In our study, Lanmaoa asiatica poisoning peaked in July, in line with previous research (13). The predominant clinical presentation among poisoned patients was the neuropsychiatric type and mixed type, characterized by visual hallucinations, fatigue, and dizziness. Some patients reported hallucinations of “little people” or “elves” dancing poisoning, which intensified when they closed their eyes. Gastrointestinal symptoms, such as nausea and vomiting, were common among patients who ingested Lanmaoa asiatica.

13 Li W, Pires S, Liu Z, et al. Mushroom poisoning outbreaks - China, 2010-2020. China CDC Wkly. 2021; 3(24): 518-522. 10.46234/ccdcw2021.134
Neuropsychiatric symptoms following the consumption of Lanmaoa asiatica, a poisonous mushroom native to Yunnan
Hong Kong J Emergency Med. 2024
doi: 10.1002/hkj2.12046

A 2025 paper:
This study employed ultra‐high performance liquid chromatography–tandem mass spectrometry to analyze the plasma metabolic profiles of patients with Lanmaoa asiatica poisoning and healthy controls. A total of 20 patients were included, with an average age of 36.9 ± 13.08 years. ... Poisoned patients primarily exhibited neuropsychiatric symptoms, including hallucinations (75%) and general weakness (60%), along with gastrointestinal symptoms such as nausea (60%) and vomiting (45%).
Untargeted Metabolomic Analysis Using UPLC-MS/MS Reveals Metabolic Changes Associated With Lanmaoa asiatica Poisoning.
Food Sci Nutr. 2025
doi: 10.1002/fsn3.70583.

From a 1991 paper:
The earliest report, published in 1991 by a Yunnan hospital, described 300 cases of xiaomei niuganjun poisonings, with effects starting 6 to 24 hours after consumption, lasting days to months, and including both open-eye and closed-eye Lilliputian hallucinations of people and animals. Most cases resolved within a few days, some within 10 to 30 days, in a subset of cases after more than a month, and in a few cases within half a year. In those with stupor, electroencephalogram (EEG) found LSD-like changes. The antipsychotic chlorpromazine was reportedly effective in managing symptoms.
The Use of Psychopharmacological Agents in China: Historical and Current Perspectives
International Journal of Mental Health. 1991
doi:10.1080/00207411.1991.11449181
 
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The odd thing is just once I had an LSD trip that unbeknownst to me seeminly had minimal effects because I had been prescribed mitrazapine (a potent 5-HT2a/5-HT2c antagonist). Well, I proceeded to demolish about 24 blotters and gave up not quite knowing why the expected ego-loss, EOVs and even colour enhancement failed to occur.

But at around T+2.30 I began to notice little people running around the edges of every surface I looked at. Quite entertaining but clearly not as expected. Specifically hundreds of 'Freds' (the character used Homepride flour ads). Mood was great to the extent that years later I recall feeling relaxed and chatty.

Now considering the dose, the delayed onset and the other receptor subtypes LSD also binds to and which mitrazepine also blocks, I wonder it it's possible to suggest other 5HT receptors? 5HT2b?

I freely admit it's very weak evidence but it stands out because of that delayed onset and just how specific the subjective effects were.

Now why ANY compound should produce such a specific alteration of perception is in itself puzzling.

Obviously at such 'heroic' doses I didn't take my mitrazapine that night and the next day WAS typical of the next-day of a huge amount of LSD.

Could be pure co-incidence but why the delay? Why would perception be altered in such a similar way?
 
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