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Misc Does Wellbutrin block the euphoria from coke and oxy/heroin?

J

john10960

Greenlighter
Joined
Oct 20, 2016
Messages
29
am on Wellbutrin and wondering this.

can anyone share any personal experiences?

thanks!!
 
On Cocaine: perhaps; perhaps not. There haven't been any studies specifically on this matter. However bupropion can help with cocaine addiction. A

But "friendliness and vigor" might decrease: https://www.ncbi.nlm.nih.gov/pubmed/11376920

Regarding opioids: no, it won't have any effect at all, except that the anxiety one could get from bupropion would decrease.
 
bindingaffinity said:
Bupropion and cocaine compete for the same transporters. I wouldn't expect to get the same euphoria off any stimulant, while taking bupropion. (Also, bupropion and other stims may both raise seizure threshold.)
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Regarding other stimulants: some people even experience an enhanced effect of the stimulant while on bupropion, and I have not noticed any difference at all, except for more irregular heart rate and more muscle spasms. Yes, it's more dangerous, but will not necessarily give you a lesser high/rush.

Someone wrote like a week ago that adding bupropion to an amphetamine solution actually amplify the rush/high. This should not be done unless one has a good amount of muscle relaxants like clonazepam, because of the seizure risk. Really it shouldn't be done at all, but people will try any way to get a higher high, so we might as well explain how to do it safely.

Cocaine is different, though, and bupropion more likely to lessen the effect, but now it was about "any stimulant".
 
sul1212 said:
Wellbutrin potentiates the shit out of MDMA, feels like heaven for 4 hours
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This is very true. Buproprion inhibits CYP2D6 in the liver, thus breaking down MDMA and raising blood levels by up to 30(!) percent and prolonging its effects, HOWEVER, in the sake of harm reduction, bear in mind that this combination ALSO increases the risk of acute toxicity, overheating, and seizures. Tread lightly.



Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects​

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3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases dopamine and norepinephrine by investigating. The pharmacodynamic and pharmacokinetic interactions between bupropion and MDMA in 16 healthy subjects were investigated using a double-blind, placebo-controlled, crossover design. Bupropion reduced the MDMA-induced elevations in plasma norepinephrine concentrations and the heart rate response to MDMA. In contrast, bupropion increased plasma MDMA concentrations and prolonged its subjective effects. Conversely, MDMA increased plasma bupropion concentrations. These results indicate a role for the transporter-mediated release of norepinephrine in the cardiostimulant effects of MDMA but do not support a modulatory role for dopamine in the mood effects of MDMA. These results also indicate that the use of MDMA during therapy with bupropion may result in higher plasma concentrations of both MDMA and bupropion and enhanced mood effects but also result in lower cardiac stimulation.
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drewbocop said:
This is very true. Buproprion inhibits CYP2D6 in the liver, thus breaking down MDMA and raising blood levels by up to 30(!) percent and prolonging its effects, HOWEVER, in the sake of harm reduction, bear in mind that this combination ALSO increases the risk of acute toxicity, overheating, and seizures. Tread lightly.
Click to expand...
Yeah at first I had a full on panic attack and my eyes were wobbling, felt like was dyeing (basically overdosing). I begged my friends to call an ambulance but then from out of nowhere this crazy rush of euphoria washed over my whole body, I could barely speak to my friends, felt like an orgasm 1000x for four hours straight. It also started my addiction and I went from straight A student to junkie:). Hell Ive shot up heroin and still that time I took MDMA was much more euphoric. Im much better now tho
 
sul1212 said:
Yeah at first I had a full on panic attack and my eyes were wobbling, felt like was dyeing (basically overdosing). I begged my friends to call an ambulance but then from out of nowhere this crazy rush of euphoria washed over my whole body, I could barely speak to my friends, felt like an orgasm 1000x for four hours straight. It also started my addiction and I went from straight A student to junkie:). Hell Ive shot up heroin and still that time I took MDMA was much more euphoric. Im much better now tho
Click to expand...
"Oop, euphoria's here. Nevermind, we good, I'm boutta nut" :ROFLMAO:
 
bindingaffinity said:
Bupropion and cocaine compete for the same transporters. I wouldn't expect to get the same euphoria off any stimulant, while taking bupropion. (Also, bupropion and other stims may both raise seizure threshold.)
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They actually do not….

Bupropion (Wellbutrin) although a NDRI it has negligible effects on the DAT 25% roughly……..minimum of 50% is required to induce euphoria in human test subject, it has a different MOA entirely

Methylphenidate (Ritalin) and Cocaine on the other hand……DO in fact complete for the same binding sites at the DAT. Human cocaine users/abuser couldn’t tell the difference if they received IV Cocaine or IV Methylphenidate. Which I was surprised to read since Cociane has robust effects at the SERT, unlike Methylphenidate (Ritalin)

Ritalin (Methylphenidate) DAT > NET. (Dopamine increase/release is 3-4X more potent than NET Norepinephrine)
Cocaine HCL DAT > SERT >> NET (Cocaine is a Triple reuptake inhibitor & Tropaine alkaloid)

However, according to current modern medical literature and several medical journals I’ve read, they all state the same unique MOA of both compounds…..Ritalin & Cocaine isn’t your “typical reuptake inhibitor” such as Bupropion (Wellbutrin) …..Ritalin & Cocaine are nearly identical in their MOA and are classified as an Inverse Agonist…..as they possess alternative mechanisms that indirectly cause the release/increase of Monoamines (not similar to classic Amphetamines) …..Methylphenidate (Ritalin) is VERY euphoric & pleasurable as its able to inhibit greater than 50% of DAT ….actually 60-75% of DAT reliably….which are significantly euphoric levels

Ritalin (Methylphenidate) is also considered a “Classic Amphetamine” in medical literature of dopaminergic stimulants and is very desirable amongst hi dose injection users, in the same category as Phenmetrazine (Preludin) which was voluntarily removed from market by manufacturer due to its insaine euphoric abuse potential apparently

Amphetamine
D-Amphetamine
D-Methamphetamine
Methylphenidate (Ritalin)
Phenmetrazine (Preludin)
Benzphetamine (Didrex)
Cocaine illicit
Piprodol

Bupropion is a beta-ketone Amphetamine analog of the Cathinone class, however at normal doses, its dopaminergic properties are ineffective at dopamine inhibition great than 20-30% which is very poor. 4-MMC is a much better Cathinone to use and is very euphoric & pleasurable.

However, Adderall, Dexedrine, Desoxyn, Ritalin/Focalin, Didrex (Benzphetamine) pro-drug metabolizes into d-Meth and then into d-Amph) and Cocaine are all Top Teir 1 dopaminergic stimulants…..get a script
 
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