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☛ Official ☚ The Big & Dandy 5-MeO-DMT Thread - Second Launch

My biggest worry is someone will drop a 5-meo-cart on the ground and some kid or some dumbfuck who's high as fuck already picks it up thinking its a weed cart.
 
Didgital said:
My biggest worry is someone will drop a 5-meo-cart on the ground and some kid or some dumbfuck who's high as fuck already picks it up thinking its a weed cart.
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random teenager hitting a blinker on a random cart they found on the ground thinking its weed
 
red22 said:
THE STORY YOU’VE BEEN TOLD ABOUT "ANCESTRAL TOAD MEDICINE" ISN’T THE FULL STORY.

New peer-reviewed research just published, and it changes the conversation.


FOR OVER A DECADE, "TOAD MEDICINE" HAS BEEN MARKETED GLOBALLY AS AN ANCIENT PRACTICE OF THE COMCA’AC (SERI) PEOPLE OF SONORA, MÉXICO.

Retreats. Certifications. Facilitator trainings.

A global market worth tens of thousands of dollars per kilogram.


THE ETHNOGRAPHIC RECORD TELLS A DIFFERENT STORY.

The Comca’ac word otac simply means "a thing that sits on water."

Jesuit records and decades of ethnographic scholarship contain no mention of psychoactive toad use.

The practice was introduced to Comca’ac territory in 2011.


RESEARCHERS CALL THIS "FABRICATED ANCESTRALITY" —

When a recently created practice is reframed as ancient to claim cultural authority and legitimacy.

It spreads through ritual, media, and global retreat economies — and it has real consequences.


INCILIUS ALVARIUS — THE SONORAN DESERT TOAD — IS DISAPPEARING.

Already extirpated in California (not seen since 1955).
Threatened in New Mexico.
Showing signs of decline across its Mexican range.
Secretions now traded at up to $50,000/kg globally.

Demand driven by narrative is demand that costs a species.


IMC FUND SUPPORTED THE FIELD-BASED POPULATION STUDY OF INCILIUS ALVARIUS IN SONORA THAT UNDERPINS THIS RESEARCH.

We are working toward:

• IUCN Red List reclassification
• SEMARNAT NOM-059 inclusion in México
• CITES Appendix II protections

The toad cannot advocate for itself. We can.


COME INTO RIGHT RELATIONSHIP.

Read the full open-access article:

"Fabricated Ancestrality: The Sonoran Desert Toad, Psychedelic Globalization, and the Ecological Politics of 5-MeO-DMT"

Psychedelics, Elsevier — 2026
DOI: 10.1016/j.psyche.2026.100012

If you work with this medicine — this research is for you.



“Fabricated Ancestrality: The Sonoran Desert Toad, Psychedelic Globalization, and the Ecological Politics of 5-MeO-DMT”

The psychedelic movement has built significant demand around Sonoran Desert Toad-derived 5-MeO-DMT, fueled in part by a narrative of ancestral use that the historical and ethnographic record simply does not support.

Now, a new peer-reviewed study by Anny Ortiz, PhD, just published in Psychedelics (Elsevier, 2026), names this process and traces its consequences for a species that is genuinely at risk.

The IMC Fund supported the population assessment that documents these concerns. Preliminary findings from this study were presented at MAPS Psychedelic Science 2025 and covered by the New York Times. The species is at risk. Formal reclassification work is underway.

Swipe through to understand what fabricated ancestrality is, what it costs ecologically, and what right relationship with the Sonoran Desert Toad, and the cultures that have always lived alongside it, looks like.

Full open-access article in bio. 🔗

If you work with this medicine, this research is for you. Read it. Sit with it. Let it inform how you move forward. Ask yourself: whose story have you been repeating, and who told it to you?

Sacred medicine does not require exaggerated timelines to deserve respect. And the Sonoran Desert Toad does not need to be a psychedelic sacrament to deserve protection.

This publication is dedicated to the memory of Anny’s father, who transcended this week. Anny was born and raised in Sonora, the very land at the heart of this research. Her love for that place, its people, and its creatures lives in every page of this work. We hold her and her family in our hearts.

#SonoranDesertToad #Bufo #IMCFund #GetBehindTheMedicine #5MeODMT RightRelationship

Indigenous Medicine Conservation Fund, h‍ttps://www.instagram.com/imcfund/p/DWhaW4nEjlp/ 2026-03-30
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Wow. Synthetic is cheaper and way more ethical. If there are other actives just synthesize them too.
 
Featherfall said:
random teenager hitting a blinker on a random cart they found on the ground thinking its weed
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It can and will happen I'm sure. But again... carts are way safer.
BorbOrB said:
Wow. Synthetic is cheaper and way more ethical. If there are other actives just synthesize them too.
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Octavio Rettig can go suck a dick
 
Didgital said:
My biggest worry is someone will drop a 5-meo-cart on the ground and some kid or some dumbfuck who's high as fuck already picks it up thinking its a weed cart.
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Tbf of all the things a vapecart could contain 5-meo is one of the mlst harmless substances.

Unless the kid takes a fat rip and jump in the lake or on a bike lol.
 
@Bitchniggaz I dunno - psychologically at least, it would be heavy and risky for someone to have an unplanned 5-MeO-DMT blast. And physically, it does seem like it can put strain on the heart. I think people have had heart attacks from vaping it before (possibly under the "supervision" of that sketch ball Octavio Reddig) Definitely want to keep it out of unsuspecting hands.
 
perpetualdawn said:
@Bitchniggaz I dunno - psychologically at least, it would be heavy and risky for someone to have an unplanned 5-MeO-DMT blast. And physically, it does seem like it can put strain on the heart. I think people have had heart attacks from vaping it before (possibly under the "supervision" of that sketch ball Octavio Reddig) Definitely want to keep it out of unsuspecting hands.
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I not gonna say there is no danger (heartwise or other) but plz remember Octavio (and dr gerry) would give out irresponsibly high doses. I know cuz i smoked 100mg toad w 75mg dmt w Gerry... I believe 4 different people died under Octavio's care, and im pretty sure he's being charged w manslaughter or negligent homicide.

Still tho. Best to not drop/lose the cart, and make sure they are clearly labeled also.

perpetualdawn said:
same goes with a baggie of dropped white powder and so on
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When i first got into the festival scene it was pretty common for ppl to groundscore bags. Reckless even then but that was back before RCs ever had a true mainstream wave. Now a days, it goes right into trash most of the time.
 
Didgital said:
When i first got into the festival scene it was pretty common for ppl to groundscore bags. Reckless even then but that was back before RCs ever had a true mainstream wave. Now a days, it goes right into trash most of the time.
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Yeah I scored a baggie of ketamine like that back in the day. Now with the ultrapotent opioids around etc I would not take any gambles
 
Personally I would never consume some random carts or powders that I found somewhere, but yeah I bet vaping some 5-meo-DMT would be a really bewildering experience if u think that it was some weed. Surprise trip for better or worse.
After our recent weekend with my degraded 5-meo I must say that that stuff is the wildest and at the same time the most blissful thing that I ever have experienced.
Even a tiny 3mg grain of it twists you real good and 6mg even more, I nearly had to puke that time 😆
One of my friends liked it very much as well and the other one didn't at all, he prefers the n,n DMT.
I did not experience a breakthrough, but I suspect the 6mg hit (with the residue from all the previous hits) was not that far from it, but my god that stuff is simply the ultimate tryptamine.
We finished off our Saturday with some AMT a few hours later, that rounded it off nicely and we had a great evening together.
 
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Chemicalfascination said:
Personally I would never consume some random carts or powders that I found somewhere, but yeah I bet vaping some 5-meo-DMT would be a really bewildering experience if u think that it was some weed. Surprise trip for better or worse.
After our recent weekend with my degraded 5-meo I must say that that stuff is the wildest and at the same time the most blissful thing that I ever have experienced.
Even a tiny 3mg grain of it twists you real good and 6mg even more, I nearly had to puke that time 😆
One of my friends liked it very much as well and the other one didn't at all, he prefers the n,n DMT.
I did not experience a breakthrough, but I suspect the 6mg hit (with the residue from all the previous hits) was not that far from it, but my god that stuff is simply the ultimate tryptamine.
We finished off our Saturday with some AMT a few hours later, that rounded it off nicely and we had a great evening together.
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I don't know where you are in the world, but if you can get some naptha, you can easily recrystallize the 5-meo and repurify. Take 1g of 5-meo, dissolve in 10mL of boiling naptha, let cool down a little bit, stick in freezer, come back 4 hours later, scrape, crush, dry.
 
Didgital said:
I don't know where you are in the world, but if you can get some naptha, you can easily recrystallize the 5-meo and repurify. Take 1g of 5-meo, dissolve in 10mL of boiling naptha, let cool down a little bit, stick in freezer, come back 4 hours later, scrape, crush, dry.
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I have n-hexane (medical grade petrol-ether made by Fischar) that I use in a large Soxhlet extractor to extract my cannabis harvesting waste and all the un-smokable fluffy buds from my grows. And if naphta works, hexane should as well and it boils at a lower temperature of 45-55°C, but that also could be an issue, since it would not reach the melting point for the 5-meo-dmt. But I have a liter of naphtha somewhere as well.
Is it really that easy, no washing in separatory funnels or so, or would it get even cleaner by washing the solution with distilled water before recrystallizing in the freezer?
PS, a friend of mine also extracts his own N,N DMT from mimosa bark using Sodium hydroxide & n-hexane and his stuff is always top.
Yeah I edit often, typos and after thinking some more about my post I often add or modify some things, but never after someone has made a post after mine.
 
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Chemicalfascination said:
I have hexanes (petrol ether) that I use in a large Soxhlet extractor to extract my cannabis harvesting waste and all the un-smokable fluffy buds from my grows, if naphta works, hexanes should as well and it boils at a way lower temperature 40-50°C, but that also could be an issue since it would not reach the melting point for the 5-meo-dmt).
Is it really that easy, no washing in separatory funnels or so, or would it get even cleaner by washing the solution with distilled water before recrystallizing in the freezer?
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Pet ether and hexanes are different. Hexane(s) should* work, it does with regular NN but it has a lower melting point. If it doesn't get hot enough to melt the 5, stick in fridge and pour off through a coffee filter you shouldn't lose hardly anything.

Heptane is ideal but naptha is a lot easier to obtain. Naptha constitiuents change by brand etc, and I'd encourage you to look at the SDS of your particular brand.

Generally I do notice while using heptane 70c to 75c seems to be the golden temperature to dissolve the 5 without dissolving impurities. The impurities tend to form an oil that separates and falls to the bottom of vessel. decant off hot heptane into a fresh container and it immediately goes white/cloudy. The slower the solution cools, the larger the crystals, although I tend to just stick in freezer unless I want to see

Ethyl acetate works but is not ideal, after freeze crashing and filtering, unless you've got a quick vacuum filter setup, the ethyl acetate tends to redissolve the filtered crystals.

Toluene prolly works but it's way too heavy and will stick in product for ages.

Chemicalfascination said:
or would it get even cleaner by washing the solution with distilled water before recrystallizing in the freezer?
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It def can't hurt however, you better make sure youre solution is dilute enough that it doesn't crash out of solution mid wash due to losing temp by touching the h2o. Trust me, a sep funnel that is clogged by a solid crystal is a pain to deal with. Maybe washing with hot water is the way to go actually? In any case if you want to wash your fb solution, do NOT use any acid/vinegar, and again you may need your solvent so dilute that you'll need to concentrate it again before initiallizing crystallization.


-----

There is also the option of an Acid Base (A/B) but you def want to be a bit more precise as you can fuck it up if you do it wrong.

Lazy explanation would be dissolve dirty tryptamine in pH 3-5 (the lower it is, the easier it is to get into solution, but you'll likely lose more)
Optional: Wash acid solution with non polar, discard non polar.
Raise pH to 12 or even 14 (most trypts are very stable in basic conditions) with stirring, keeping solution from getting too hot. NaOH is fine, not sure about NaCO3
Stick in fridge. The FB tends to coagulate into chunks that are easily filtered out.
Filter out
wash with plenty of distilled (to remove excess base)
Dry.
Optional would be to re-x after the A/B

If grown slow it forms crystals with clear sheaths/plates that glimmer like mica the mineral.

 
Chemicalfascination said:
hexane should as well and it boils at a lower temperature of 45-55°C,
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I actually think the 5 doesn't need to be at melting point for it to dissolve in hot hexane. Not sure how much you'll need but I suspect 10mL per g of 5??

Also just an FYI, both N,N and 5 are actually both pretty thermally stable. You can melt it and pour it into molds etc and it's totally fine.
 
Thank you very much for your answer. I will order a smaller 150ml sep funnel and try the simple method using my old painters supply naphtha with its unknown content with around 0,1g first and some washing with 60°C distilled water. I will use a very diluted solution as you suggested and distill off most of it before recrystallizing.
After all the degraded 5-MeO was cheap and if I loose some I will learn from it.
However I have some doubts about the purity of that old naphtha and the possible nasty remains in the end product. I will look for some lab or technical grade stuff first, my favorite local pharmacist has no problem with taking my orders if I ask him nicely ;)

Edit, yeah it should dissolve it I think, since it works well with the nn dmt, but I'm not 100% sure. It would also put my mind at ease knowing that my solvent doesn't leave unwanted residues and benzene. I had 0,5g of 5, I will simply use a lot of solvent, like 50ml for 0.1g, so that I can wash it with lukewarm dist. water without blocking up the funnel. Also good to know that it is a robust molecule.
 
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