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Opioids 80mg oxy dosage for first timer ?

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I feel sorry for Americans getting conned by Oxy's. They are expensive, weak and makes people forget they are abusing opiates. Ask yourself this would you sniff heroin or smoke it? If the answer is no now, then im sure in time your opinion will change.

Dont piss about with opiates. Just cus Suburban kids feel safe, cus they are away from the ghetto, this is the new heroin. Only its weak and expensive.
 
Doug2113 said:
Umm...Oxycodone is about 2.5-3 times as potent as hydrocodone. So 80mg of oxycodone is equi-analgesic to 200-240mg hydrocodone. Granted, like said earlier, less than half of the drug is released initially, but it would still be as potent as about 80-100mg of hydrocodone.
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Wait, what??? Where did you get that info? Cause it certainly is not correct....
 
I think a lot of you are getting confused, or are just not informed enough or experienced enough with Oxycodone. Even if you have zero tolerance, 40mg of Oxycodone would not be enough to make him deathly sick, worst case scenario he'll just throw up and feel sick from it. However, he has an 80mg Extended Release tablet.

OP, if you take the entire pill on a full stomach, I'd imagine you'll feel just fine. You may feel a little groggy, but you won't be deathly sick or have to be hospitalized. Just to be safe though, take half and wait an hour or two, then take the second half.
 
^You have to remember that everyone's physiology is different, and drugs effect everyone differently.. While there may be certain individuals who can handle 40mg of instant release oxycodone with no tolerance, the fact is that the majority of people cannot. I have been a heroin user for a number of years, and before that daily usage of oxycodone. I remember back in high school when I first started experimenting with percocet, 10mg would have me very high, and borderline nauseaus. 20mg would have me throwing up, sweating, spinning.. If I were to take 40mg with no tolerance back then, I would probably be so sick that hospitalization would be a good idea.

Just because you can handle something, doesn't mean everyone else can. It is not in line with harm reduction to tell people to start off with practically heroic doses that could make them have a completely un-enjoyable experience.

A saying I like to remember when trying things out, is "You can always take more, but can't undo it once it's done."

Start small.
 
Hell no. Way too high of a dose. You will probably end up on your back vomiting. Don't do it. Try 10 or 15mg.
 
TheAzo said:
No, Oxycodone is 1 - 1.5x the potency of hydrocodone.

And, to the OP - 40mg with the time release intact would be appropriate for you, maybe a bit strong. If you defeated the time release (dissolving pill in cocacola should work) then 10-20mg would be appropriate for the initial dose.
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Your very, very wrong. Oxycodone is AT LEAST double the strength of hydro, and depending on your physiology, could feel 3-4x the strength.

Oxycodone is about double the strength of hydro, with a conversion ratio of 200%-350%, if I recall. So best case scenario, the oxy will be at least double the strength, worst case, triple the strength, with most people getting about twice as much per mg out of oxy. So my question is, WTF gave you the idea that oxy and hydro we're the same potency??? Seriously, that is the opposite of harm reduction, as 40mg hydro might get some wasted, BUT if they take 40mg oxy, they would be fucking puking. Research before you type, man.

Oxycodone 10mg= Hydrocodone 18-30mg
Thus:
40mg hydrocodone= roughly 12-20mg oxycodone
and
80mg oxycodone= somewhere between 160-320mg of hydro
 
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Doug2113 said:
Umm...Oxycodone is about 2.5-3 times as potent as hydrocodone. So 80mg of oxycodone is equi-analgesic to 200-240mg hydrocodone. Granted, like said earlier, less than half of the drug is released initially, but it would still be as potent as about 80-100mg of hydrocodone.
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He is absolutely right. According to 2 conversion charts:

30mg codeine= 5mg hydrocodone= 1.5-2mg oxycodone
and
10mg morphine(ORAL)= 16.67mg hydrocodone= 4.5-6mg oxycodone

1-1.5x the strength, are you out of your fucking mind!!!!!!!!!
 
damn that is alot, like first time i ever tried an oxy(20Mg CDN), i didnt even do whole thing, just a half or 1/4 of it and felt something heavy. but everyone is different but stay safe man.
 
No -- I'm not buying all of this. Hydro and Oxycodone are very, very close to be equivalent in strength when taken oral. I could *maybe* see oxycodone being listed as 1.5X as strong as hydro for some people. Those of you who are screaming that it is anywhere from "2X to 4X as strong" are just out of your respective minds and you certainly are opiate naive (which is pretty funny in itself because these doses being discussed are VERY low and the OP/most responders in this thread are opiate naive).
 
No, you have it opposite. FOR SOME PEOPLE, Oxy may be only 1.5x the strength, though this is only in people with an odd physiology. But to everyone else, it is over twice as strong, and for people with CYP2d6 deficiency, oxy may very well be 3-4x the potency, since it has action on it's own, versus hydrocodone, which gets it's minimal action from it's parent -morphone metabolite. Why do you think they cap hydro at 10mg doses? It is the weakest opiod with true full agonist effects in use, which is why it's the basic "your bitching about something unimportant, here is 15 Vicodin".

And I am not opiate naive, my friend. Anyone here knpws that. I won't deny that oxy is only 1.5x the strength FOR YOU, because everyone is different. But I don't care who you are; there is not an experienced opiate user on this fucking planet who will tell you that oxy and hydro are equal. Why??? Becuase oxy is double the strength!!!!!!!!!!!!!!!!!!!!!!!!!!!

So feel free to disagree, but don't start calling people out when it is a certifiable fucking fact that oxy is much more potent.

(Edit to say that for me, personally, hydrocodone is just as useless as tramadol and darvon, BUT if I had to convert the doses, I would take a little over double; YMMV)
 
One thing that you're not taking into account is that you're taking these for recreational purposes. Every drug is going to have a completely different narcotic-effect profile. Just because you don't feel twice as fucked up on oxycodone as you do on hydrocodone does not mean that it isn't twice the potency or relieves twice as much pain. Take it from a chronic pain patient. Endocets kicks the fuck out of Vicodin when it comes to pain. Ya, 20mg of oxycodone might not have the "feel-good" effects of 40-60mg of hydrocodone, but it sure as hell gives that much pain relief. And lorne is definitely not opioid naive lol. I don't know them personally, but from what I've seen in threads about mainlining, and speaking in PM with them, they seem to know what they're talking about and has experience.
 
^Thanks man^

No, I am NOT opiate naive, haven't been for a long time. But Doug put it perfectly talking about actual pain-relief. That is technically what "potency" refers to, NOT how fucked up you can get on it. For example, 25mg of CHRONIC methadone in an individual addicted to opiates is supposed to be equal to 80mg of oxycodone. Now even I have some qualms of that number, I think 60mg might be closer, but the point is, 80mg of oxy will get you "higher" than 25mg of any day. BUT they are similar in actual potency(yeah, that's a bad example because the doses are so low, but that is one where the math comes fresh into my mind, being surprised methadone was that much more potent)
 
I'll tell you though, when Im sick/WD- I would take 25mg of methadone over 80mg of oxycodone anyday. But, yeah; analgesic effect and euphoria are definitely different concepts.

As far as taking too strong a dose, I think having someone else present, especially if they know cpr and how to administer narcan, is one of most important things to do. Especially when trying something new, or doing a higher than normal dose.
(Not that I'm condoning taking as big a dose as you want cause you can be resuscitated. Just saying from a HR view, having a second person on hand is important.)

80mg of oxycodone ER isn't likely to OD anyone who has even a little bit of tolerance, but that doesn't mean it will be enjoyable. From experience, taking more than needed to get off, but not enough to OD you is not just dangerous but extremely uncomfortable. That's why when some people try opiates for the first time, they have a poor experience cause they took more than necessary and ended up puking all nite with a headache. I never tell them that tho, cause that's usually the last time they do it. Easiest way to make someone who's never done opiates to stay off of opiates forever is give them a 8mg suboxone.... after the 4th time they puke they'll never want to touch them again.
 
nonug said:
Everyone in this thread is straight TRIPPIN. The OP would be absolutely FINE if he did the entire 80mg at once. Even if it were an IR pill, he would STILL be completely fine. This guy basically doses 40mg of hydro twice a week every week. Sure, 80mg will have you feeling very good, but it is not a dangerous dosage whatsoever considering your "tolerance."
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Your stupid. A 40mg oxy op can knock someone straight out.
and fyi, 40mg hydro ~= 20mg oxy.
 
lazylazyjoe said:
I'll tell you though, when Im sick/WD- I would take 25mg of methadone over 80mg of oxycodone anyday. But, yeah; analgesic effect and euphoria are definitely different concepts.

As far as taking too strong a dose, I think having someone else present, especially if they know cpr and how to administer narcan, is one of most important things to do. Especially when trying something new, or doing a higher than normal dose.
(Not that I'm condoning taking as big a dose as you want cause you can be resuscitated. Just saying from a HR view, having a second person on hand is important.)

80mg of oxycodone ER isn't likely to OD anyone who has even a little bit of tolerance, but that doesn't mean it will be enjoyable. From experience, taking more than needed to get off, but not enough to OD you is not just dangerous but extremely uncomfortable. That's why when some people try opiates for the first time, they have a poor experience cause they took more than necessary and ended up puking all nite with a headache. I never tell them that tho, cause that's usually the last time they do it. Easiest way to make someone who's never done opiates to stay off of opiates forever is give them a 8mg suboxone.... after the 4th time they puke they'll never want to touch them again.
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Second that. If you know what WD feels like, then you know 25mg of MD is going to give you more relief than 60-80mg of oxycodone, no question(again, the doses are low, but you know what I mean) Also, whippa cracka is straight on. Glad to see some people with sense in this thread...
 
For me, it seems hydrocodones weaker than oxycodone. Like 20mg hydrcodone= 15mg oxycodone for me. And 80mg is way to much. Maybe around 50-60mg save the rest for another time.
 
lorne667 said:
LOFL. I am surprised people are suggesting a quarter dose. Remember, LESS THAN HALF of the dose is released initially, so a quarter of an OP 80 would be like a oxy 7.5mg with a killer half life.
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I was spending a night in jail on time, and a older fellow that was my cell mate for the night got a parole violation due to an overdose he experienced from eating a op80. He was a heavy set guy as well. So yea just trying to keep this member out of trouble. You know better safe than sorry. And look at the title of the thread!! This is a harm reduction web site right?
 
krazikomi said:
I was spending a night in jail on time, and a older fellow that was my cell mate for the night got a parole violation due to an overdose he experienced from eating a op80. He was a heavy set guy as well. So yea just trying to keep this member out of trouble. You know better safe than sorry. And look at the title of the thread!! This is a harm reduction web site right?
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...I think you missed my point. Just read through the other posts, telling him "fuck it, 80mg oxy is jus like dam 40mg hydro mo fo" and you'll see my point.
 
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