Unless someone puts a powerful NDMA antagonist in your spice, you smoke it and instead of stoned you go into a state like a k-hole for a while.
People would smoke it and be like "man i got so fucked up from that spice"
The point is that the subtle structure differences in the JWH series, and other chems that are put in spice make them all significantly different. Different dosages, binding affinities and minor actions elsewhere in the mind and body, different metabolic products... It gets you high, but there are a lot of different kinds of high, some amazing and others scary. And the simple fact is that we don't fully understand the JWH compounds and what else they do other than being cannabinoid agonist.
I figured once it got started in Germany it was going to spread. I'm concerned that it could hurt people," Huffman said. "I think this was something that was more or less inevitable. It bothers me that people are so stupid as to use this stuff" --John W. Huffman
The man that made them expresses concern over safety. That alone justifies concern over safety, especially when you have no idea what your smoking. Might not even be JWH, could just as easily be an AM, RCS, URB, or WIN. These other types of cannabinoids are going to surge in popularity with the JWH becoming more and more restricted.
URB-597, I think it was acts by inhibiting the enzyme that breaks down endogenous cannabinoids already present in our bodies to a degree that results in them accumulating enough for psychoactive effects.... Sort of like an MAOI type action targeted at endogenous cannabinoids.
And people not liking chemical structures, its more a lack of appreciation they deserve? If they like getting high, they damn well should appreciate the chemical structures that get them there. We are nothing but a culmination of chemical reactions and electrical impulses so expansive that it goes beyond all our comprehensions. When you start throwing outside influences into the equation, it doesn't matter what drug it is, a single atom can be the difference between it being inactive or having a dosage in micrograms, a fluoroacetate metabolite that could be lethal or a novel neuroprotective drug.