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  • BDD Moderators: Keif’ Richards

Alright now i need some advice.......MORPHINE E.R

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Actually, acetaminophen isn't an NSAID : P

http://en.wikipedia.org/wiki/Acetaminophen

If it was an NSAID it would cause stomach issues as opposed to liver hepato-toxicity.

And you don't face acute liver toxicity until you hit 10-20gs (10,000-20,000mgs) in a 24-hour period. What you are speaking of is long-term chronic use. It will cause damage over time, but so will everything else you do.

It can be classified as an NSAID by some, and not by others

It is currently in question on what it "officially" is
 
Actually, acetaminophen isn't an NSAID : P

http://en.wikipedia.org/wiki/Acetaminophen

If it was an NSAID it would cause stomach issues as opposed to liver hepato-toxicity.

And you don't face acute liver toxicity until you hit 10-20gs (10,000-20,000mgs) in a 24-hour period. What you are speaking of is long-term chronic use. It will cause damage over time, but so will everything else you do.

Doug, you are correct on the nsaid, not sure why I put that there, but as for the toxicity what is written in all the medical journals I have and you can google it the threshold considered to be dangerous and what it recommended by the manufacturers is not more the 4Gs per 24 hours. It is even written here in these forums. Not 10-20 as you indicate.

Infact in one article it stated that in a blind study individuals who were given 4G's of Tylenol vs placebo 33% had an ATL (liver enzyme) reading of 500 which is approx. 10 times the upper normal limit. If you do further research, please see the following from the FDA, it clearly states that the recommended maximum dose is 4G's per day. And anyone who drinks alcohol should not exceed 2.5 grams per day.

http://www.fda.gov/downloads/Adviso...afetyandRiskManagementAdvisoryCommittee/UCM16

I cant find it right now but there is further documentation that says that they are lowering the recommended maximum does to 2-3 grams per day. If I find it I will post it.

However you are correct on the nsaid, I will remove that from my post, tylenol is neither an nsaid nor a cox-2 inhibitor like celebrex, infact I don't even know if it has a class or not lol. So I'll remove that from my post but the rest about the daily limits are staying as they are documented as stated as although most may not hit acute liver failure due to toxicity at the levels I quotes, some people can and have. It is all based on the individual and it is best not to go over the FDA recommendations anyway.

Taking the one dose here is like just giving me a childrens chewable tylenol it doesnt work, but as soo as you take more than prescribed oh shit watchout its dangerous ur an addict and shit like that. Well if the damn doctors would get it correct and quit trying to make so much money off of everyone then .we wouldnt take so much to get outta of pain. Dont get me wrong i like to get high because i feel great and absolutely no pain. But would rather be pain free than high anytime of the day.

I'm with you 100% Draven, my Liver disease is terminal and my Dr gives me shit about being on pain meds and is always trying to get me off of them. I keep telling him that you don't get it Doc, I would much rather live a shorter pain free happy life, then a longer miserable, in pain everyday life. He just can't get that through his thick freaken skull and it sucks! It's all because all Schedule 2 narc are now under the watchfull eye of the DEA and the Dr's are scared shitless to prescribe them anymore... It's BS! Anyway I hope you found my post helpful and please see my last post just to clear things up with Doug, and Doug, I'm not saying your 100% wrong, because your not, then again niether am I. We are both correct, it's just in the symantics. (did I spell that right?)
 
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My doses were for a lethal dose

The OD-50 of any drug is going to be drastically lower than the LD-50.

But I'll quit arguing as I'm merely arguing semantics lol.

Don't take more than 4gs. lol

"The technical toxic dose is 10,000."

Granted it's from yahoo answers, I've read it elsewhere as well.

And it's semantics : P

Sorry to hear about your liver disease. Yes, it would be nice if doctors understood that shorter and less painful is better than agonizingly long.
 
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Let me just say, fwiw, MS Contin sux. You really dont get anything from it, and its addictive as hell. MAybe not mentally, but, physically, it can be a bitch. I know because I did the same thing with my docs for my spine problems. I started at 15 mg, it didnt work, went to 30, it didnt work, went to 60, and we held there because if I took more, I would get sick and puke all day. I have been on opioids for a little over 3 years now. I had never had any problems with my meds until the ms contins came into play. After I realized I had a problem with them and wasnt getting any relief, I told my doc that we needed to titrate down and off of them. It took 3.5 months to get off them and it was the worst thing I have experienced. If you arent getting relief with your current regiment, bitch, bitch, and bitch until you get a change for the better. Its what I had to do. I have found that Fiorocet has been a great supplement to my pain regiment, but it contains APAP and if you take other meds with APAP then it may not be for you.
 
It's cool bro thanks, and yes that was my point we were arguing semantics which makes us both correct. As for my liver disease (not trying to troll on this post) I've come to terms with it and hell we are all going to die someday I just happen to know I'm going sooner, but I refuse to go in pain. But it's all good! Hopefully we'll get to battle on semantics in another thread soon :)

Thanks for the condolences though, it means a lot to me that people actually care enough to say it :)
 
Let me just say, fwiw, MS Contin sux. You really dont get anything from it, and its addictive as hell. MAybe not mentally, but, physically, it can be a bitch. I know because I did the same thing with my docs for my spine problems. I started at 15 mg, it didnt work, went to 30, it didnt work, went to 60, and we held there because if I took more, I would get sick and puke all day. I have been on opioids for a little over 3 years now. I had never had any problems with my meds until the ms contins came into play. After I realized I had a problem with them and wasnt getting any relief, I told my doc that we needed to titrate down and off of them. It took 3.5 months to get off them and it was the worst thing I have experienced. If you arent getting relief with your current regiment, bitch, bitch, and bitch until you get a change for the better. Its what I had to do. I have found that Fiorocet has been a great supplement to my pain regiment, but it contains APAP and if you take other meds with APAP then it may not be for you.

What is fwif? And morphine seems to help with my pain,granted I've never taken it chronically and hydrocodone helps me, so maybe that's why. I have been letting them know that it's not working. They just added gabapentin and they keep titrating the amount of times I take it daily even though it's not really doing much anyway. I'm only taking 300mg/dose so that could be a factor. They really don't want to put me on anything scheduled lol.

It's cool bro thanks, and yes that was my point we were arguing semantics which makes us both correct. As for my liver disease (not trying to troll on this post) I've come to terms with it and hell we are all going to die someday I just happen to know I'm going sooner, but I refuse to go in pain. But it's all good! Hopefully we'll get to battle on semantics in another thread soon :)

Thanks for the condolences though, it means a lot to me that people actually care enough to say it :)

Thats the right idea...I always said if there was a zombie apocalypse the way I'm going is by IV OD of some type of hard opioid. Not gonna wait to get eaten/infected, and there's no way I'd have the balls to pull a trigger lol.

But ya, no problem on that last part. Not a big deal at all...And I'm sure we'll see each other around here from time to time : P.
 
What is fwif? They just added gabapentin and they keep titrating the amount of times I take it daily even though it's not really doing much anyway. I'm only taking 300mg/dose so that could be a factor.

I was going to ask the same question as to what fwif was myself.

As for the gabapentin aka Nuerontin, it's really a very particular kind of aid in relieving pain. You may know this already and if you do my apologies, if not, then you'll find this interesting. This drug was originally developed to treat seizures and is sometimes still used for that, but as time has gone on they have found it more effective at being a mood stabilizer in people with anxiety, depression, and or bipolor, as well as a pain reliever for nerve damage / nerve related pains and migraines. With the nerve pains it helps a lot with the burning, tingling, pins and needles type pains you get with a damaged or pinched nerve. I'm not 100% on the details but it works by suppressing or slowing the way the nerves relay the signals to the pain receptors in the brain. A while back I had a pinched nerve and they prescribed gabapentin at 600MG's 3 times a day and it worked pretty well. To me however, I just felt like it was an awful lot of medication for my body to have to filter out for the pain I had so I stopped taking it. Again my apologies if you knew all that already but most people don't know the full story behind that drug. And FYI to anyone who wants to know if there is any recreational value to it, the answer is 100% NO, it is not a CNS drug or a barbiturate as commonly prescribed for seizure conditions, so don't waste your time trying if you have it and want to. It's not that kind of med.

Thats the right idea...I always said if there was a zombie apocalypse the way I'm going is by IV OD of some type of hard opioid. Not gonna wait to get eaten/infected, and there's no way I'd have the balls to pull a trigger lol.

Hells yeah bro, that's one area I can say we agree 100% no semantics in the way here! :) lmao
 
I knew that about the drug as far as the pain relieving part, but didn't know about the off-label psych indications. It seems to help a little bit, but when I go to straighten my back (I have hyperkyphosis) I still feel a sharp pain from what I think is a pinched nerve. Maybe it's not a pinched nerve though.

EDIT: I was actually prescribed lyrica at first but the neck suckers, more commonly know and insurance providers, decided I didn't need that med and wouldn't cover it, so I got gabapentin lol.
 
I knew that about the drug as far as the pain relieving part, but didn't know about the off-label psych indications. It seems to help a little bit, but when I go to straighten my back (I have hyperkyphosis) I still feel a sharp pain from what I think is a pinched nerve. Maybe it's not a pinched nerve though.

EDIT: I was actually prescribed lyrica at first but the neck suckers, more commonly know and insurance providers, decided I didn't need that med and wouldn't cover it, so I got gabapentin lol.

Just did a quick search online as I was curious if that's typical to prescribe neurontin for that and apparently Lyrica is indicated first and neurontin is a close secons, guess that explains why the insurance won't cover the lyrica, since neurontin is WAY cheaper. Mother F'ers. Insurance companies need to quit deciding our treatments, that what we pay the Dr's for damn it! If your insurance pays for your doctor they should trust that doctor to prescribe the best treatment for your condition instead they dictate back to the doctors what they should be prescribing! F'ing bullshit!

As you can tell I get a little heated over that topic, makes me very angry.
 
As you can tell I get a little heated over that topic, makes me very angry.

Hey im with you on that if you really think about it if the doctors would actually do their jobs and give you the right meds instead of having u try all these different ones people who are so much in pain get dependent on them. And then the doctors say when you run out a freakin day early that ur using way too many or crap like that. Also Thank u all for all the useful info. If it wasnt for all of u shit i would still be just wondering and not knowing about some of this crap. And just talking to others who know exactly what im going thru. THANK YOU GUYS......Draven
 
I'm sorry you're in such a bad situation, and I'm really glad talking to others has helped.. it sucks that you guys can't get the pain relief you need <3

However, in BDD we have a lot of traffic and because we encourage people to start their own threads, we have to try to keep them fairly short and sweet. I'm going to close this as your original question's been answered and it has become more of a discussion about doctors/insurance companies, but feel free to come over to the social thread if you want to chat! :)

Oh, and APAP has a degree of NSAID activity but I would never call it an NSAID as it has an entirely different effects profile, and it just leads to confusion. It's not classed as an NSAID in the medical literature.

If anyone has any queries feel free to shoot me a pm :)

Shoot me a pm if you have any questions.
 
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