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  • BDD Moderators: Keif’ Richards

First pass codeine blast

B

bpayne

Bluelighter
Joined
Aug 26, 2008
Messages
1,549
So here's the deal and if this is in the wrong place or the wrong format then by all means move it on out of here. but here goes:

We all know that redosing codeine is suppose to be useless.. well heres what happened.. I measured out a dose but only took half of it because something happened I had to take care of immidately.. it only took me about 15-20 min to handle my business, so I went right to grab the other half of my dose.. now I was just starting to feel the first half I took.. but I tossed back the second half of the dose anyway not thinking about the first pass rendering my enzyme converters possibly useless.. so the question is this.. would that have wasted my second half of the dose? was it already to late.. or you think It can still squeeze out more morphine cause it hadn't been a whole hour or something.. yeah I know kinda ridiculousness but I would like to know ya'll take on the first pass and enzyme inhibition on the whole codeine to morphine metabolizing thing. Thanks Ya'll
B
 
Why don't you tell us how it went?

I think in general it is best to take your codeine in one bolus dose. Not that it will ruin the trip if you take it ion 2 halves, it will just be a lot stronger if you had taken them both at once.
 
well.. I usually don't feel much more than the relief from it anyway.. maybe a little flushing warmness I do feel the effect seems a little more lasting with the Initial feeling that I got from it.. instead of going away in one hour like usual it is hanging on into the third hour no increase in intensity was noticed. I have a weird tolerance though. it is fairly low compared to opiate vets because my doc is tramadol and kratom. but I've had experience with all kinds of things including oxymorphone, hydromorphone , and suboxone. the Sub I used for a good 4 months recreationally and withdrew from that for a whole month..
I don't think it was all the way wasted.. but the second half of the dose wouldn't have done much anyway taken on it's own.. first half was about 100 mg. and the second half was probably only about 40..
What I'm really wondering is probably more suited for advanced discussion if anyone who knows about cyp2d6 inhibition from codeine's first pass metabolism.. does anyone know more into the science of that.. and why is it known to cause an inhibition that works against redosing?
This post however is more anecdotal than advanced so that's why I put it here.. I have no idea.. codeine doesn't do a lot for euphoria wise anyway seem like a lot of the euphoric properties of opiates have become much less evident.
Guess I got use to them lol.. that's what they call the "magic" I suppose.
Don't get me wrong if I take 30 mg of oxycodone I feel good if I took 40 there would probably even be euphoria present.. but I dont want to get into higher doses
Codeine is interesting because there is conflict between whether it's the conversion to Morphine or also additional mu agonists also being converted that are primarily responsible for it's effect .. and it is said that the enzymes responsible for this are inhibit after the first use so redosing is pointless..
Anyone know more about how this works?
 
during my stay in france, i would dose 3-4x a day with satisfactory results. maybe it is something to worry about with a limited amount of codeine, but you can definitely redose with it and get high again.
 
I have never been able to re dose codeine without getting sick. But thats just me. It probably wouldn't have wasted it, it would be weaker compared to if you would have taken it all at once
 
xbloodwhipx said:
I have never been able to re dose codeine without getting sick. But thats just me. It probably wouldn't have wasted it, it would be weaker compared to if you would have taken it all at once
Click to expand...

Same here, but for some reason I can take promethazine and codeine and not get sicc when I redose? The sizzurp shit haha.
 
what do u mean by getting sick? like some sort of precipitated withdrawal? cause that sounds weird.. or do u mean you get an upset stomach?
I have a pretty strong stomach.. like for instance I took a whole bottle of codeine cough syrup (no prometh I hate that stuff) then proceeded to drink 6 beers and then eat a bit of kratom all on an empty stomach and didn't have the slightest hint of nausea. but that's just me though
 
well I didn't think so either. but I was wondering what they meant by sick.. when I think of opiates and the term sick I usually only associate it with withdrawals but I guess some people do throw up from them as well
 
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