Yes, because they only need to be able to synergize with or modulate the effects for them to become subjectively different. There are just too many reports, in my opinion, about certain extracts being more deep/serious/dark/spiritual/... and they sometimes aren't even considered red spice. From what I've heard red spice is another thing altogether. The first DMT that I ever had was actually very red (not orange or brown, but really red), but I had no frame of reference back then. It was quite powerful for something that didn't look pure, it might have even packed a punch synthetic did not have. But synthetic was the cleanest vape imaginable for me which makes sense.
Extracts consistently 'told me a story' that pretty much always involved the elves or at least their realm. With the synthetic though, it was like a lot of the elements were there and in pure or clear form... but the narrating spirit was somewhat lacking or missing. I have come across this phenomenon before and it is with mushrooms, which also tend to 'tell a story', as if guiding. There are two directions you can go from mushrooms which is towards the synthetic side (like synthetic psilocin, metocin or psilacetin) or towards the more spiritual side such as with psilohuasca. Whether I'm convinced of shamanistic principles or not, it really seems like natural products like DMT extracts and mushrooms with or without harmala incorporate modulating compounds like MAOIs but there may be other ones. OK with mushrooms by themselves it might be written off to placebo, but with psilohuasca this is certainly not the case.
Another convincing argument is that some DMT alkaloid mixtures like red jungle spice can become orally active which testifies of either MAOI activity (probably) or wholly different and novel psychoactivity. Perhaps both.