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Will put you to sleep (Help for tweakers)

^ What?

Seroquel is a dopamine antagonist so while it's active, yeah it does block dopamine's effect. But in theory, as an antagonist, it should actually upregulate dopamine receptors.
 
footscrazy said:
^ What?

Seroquel is a dopamine antagonist so while it's active, yeah it does block dopamine's effect. But in theory, as an antagonist, it should actually upregulate dopamine receptors.
Click to expand...

Theoretically, there would be up-regulation of dopamine receptors in an attempt to compensate for the Seroquel antagonism. I haven't read much about this line of thought though for this class of drugs, though I can see that playing a role in psychosis induced by abrupt withdraw of anti-psychotics in long term therapy. With short term or irregular use, this shouldn't be so much a problem.
 
Since I take ultra low dose naltrexone to reduce opiate tolerance, at one point I wondered whether seroquel could be used the same way to prevent ice tolerance, or perhaps upregulate receptors that had been down regulated through long term abuse. Doesn't seem like it'd be that effective though as seroquel and methamphetamine target different dopamine receptors.
 
I don't know. People always say benadryl and allegra knock them on their ass, and I feel like a golden dildo within the hour after taking them. Same with stims, caffeine knocks me on my ass just like every other stim.
 
I know people who have got twitches (TD like symptoms) from using them just a few times..
I am one of those people every time i take seroquel i find i get muscle twitching in my face.
Seroquel has heaps of sides stick to benzos for meth comedowns it has many benefits. Catapres is also a good option and what my doctor has scripted for regular after amphetamine use for sleep.
My doctor also advised it wasn't i good idea after stims to take seroquel.
Taking a Atypical antipsychotic regularly after meth is not good for your brain.
Where are you getting the info that seroquel up regulates dopamine receptors? that would be counter productive for what its scripted for wouldn't it?
 
The brain is constantly trying to create equilibrium. This is where tolerance comes from. Too much of a dopamine agonist (like meth) and your brain will downregulate dopamine receptors so that the amount of dopamine stimulation returns to baseline. In the same way, too much of an antagonist, which blocks dopamine's effects (like seroquel) and your brain will try upregulate dopamine receptors to return to a baseline level or normal stimulation. So yeah, seroquel will become ineffective over time in the same way as a meth addict requires higher and higher doses for the same high.
 
The mechanism doesn't seem to be entirely analogous to that with meth though, as evidenced by patients who take a regular dose of Seroquel for years and continue to experience suppression of psychotic symptoms. At the very least, the tolerance doesn't come into play quite as quickly. Some interesting neuropharmacology at play here...
 
I can't remember where I saw it ( Erowid I think ? ) but I recall one of the reasons seroquel had fallen out of popularity was the risk of Tardive Dyskinesia after very few doses. IIRC it also has a fairly high rate of idiosyncratic reactions compared to other anti-psychotics
 
^ Any chance of finding some more info about risk of idiosyncratic reactions with Seroquel vs. other atypical antipsychotics? I might try and pull up some eMIMS info today.
 
Last weekend i decided to try Phenergan, i tried 50mg sober and found it put me to sleep fast for a good solid 8 hours.
After being awake for 2 days, and taking RC's only i took 50 MG of Phenergan, 30 minutes later, i could hear music being played in my head, i was answering questions to people that did not exist all these psychosis type things happened. WTF was going on there? Can any explain why this happened?
 
Seroquel/Quetiapine at low doses (25 to 100 mg) is basically an antihistamine - it's not an antipsychotic. Therefore you don't get those side effects such as Tardive Dyskinesia and Akathisia.

http://thelastpsychiatrist.com/2007/07/the_most_important_article_on.html

http://www.ncbi.nlm.nih.gov/pubmed/15029469?dopt=Abstract

http://www.europeanneuropsychopharmacology.com/article/S0924-977X(00)00133-4/abstract

http://thelastpsychiatrist.com/2007/08/arent_two_antipsychotics_bette.html


As with most neuroleptic antipsychotics, the prolonged use of high doses (over 200 mg) of quetiapine increases the risk of the patient developing tardive dyskinesia, an incurable neurological disorder.[14][15]

http://en.wikipedia.org/wiki/Quetiapine
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I would say I have tardive dyskinesia from using 600-1000mg of seroquel for about 7 months straight.

Although I had random twitches before I went on the seroquel, they have gotten markedly worse since taking.
 
I have found just have my lasts good hits at like 3-4pm and then drink some vodka/scotch smoke some beautiful hydro, and then 15mg diazampam, I can get this like sleep/half a awake states, that rest for a next day abuse session.

I'm happy I ran out of ice tonight.
 
drug_FUCKED said:
I know people who have got twitches (TD like symptoms) from using them just a few times..
I am one of those people every time i take seroquel i find i get muscle twitching in my face.
Seroquel has heaps of sides stick to benzos for meth comedowns it has many benefits. Catapres is also a good option and what my doctor has scripted for regular after amphetamine use for sleep.
My doctor also advised it wasn't i good idea after stims to take seroquel.
Taking a Atypical antipsychotic regularly after meth is not good for your brain.
Where are you getting the info that seroquel up regulates dopamine receptors? that would be counter productive for what its scripted for wouldn't it?
Click to expand...

You/They probably have taken high doses of Seroquel.
 
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