No offense, but I'm a little skeptical of some of your inferences of 5ht effect-profiles from the character of experiences. I'll admit that 5ht affinity must have something to do with coke's unique effects, but extension to things like high dose mdpv seem dubious. Hell, I wonder whether 5ht efflux really plays that much of a role in meth's case, as selectivity for DA, strength, and duration explain a greater proportion of meth's unique feel.
For example, acutely dosed SSRIs tend not to impart of any of the attributes you claim 5ht reuptake inhibition to accord coke or high dose mdpv. Now, I'm sure that speed of onset, binding affinity, and severity of 5ht blockade matter a lot, but the gulf between this '5ht reuptake inhibition feel' of stimulants and that of SSRIs is greater than the gulf between those long time-course RTI compounds and more typical DARIs.
But I don't know the story either...
ebola