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Methoxetamine's Therapeutic Value

KuSh Boii Whip

KuSh Boii Whip

Bluelighter
Joined
Dec 15, 2010
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49
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Canada
hey guys, was thinking at work one day and came across an idea..

considering mxe's potential to be an anti-depressant, and also something to decrease social anxiety; i was thinking that if there would be anything to be able to make the half life even longer than it already is (like an extended release type thing) then it would have great potential to be even a prescription drug.

i was wondering this because if its possible then i would probably use it myself for the social anxiety aspect. ive noticed that when i do methoxetamine it opens me up and im not as much of an introvert like my sober self. but i dont want to always be feeling the dissociated headspace.. what i was thinking is that if there was something that slowed down the metabolizing of the compound then in the morning you could take something like 5mg with this *enzyme inhibitor(?) and then the rest of the day you'd be set...

sorry if there has already been a thread like this, it was just a thought i was pondering during the last week or so
 
Methoxetamine is a good dopamine reuptake inhibitor, that's probably what youu're feeling.

The usage of arylcyclohexylamine dissociatives has been hampered to a large degree by 1. tolerance that builds rapidly in the case of misuse, and 2. the sometimes unnerving and/or manic psyhcoactivity that some compounds are prone to exhibit.

The dissociative headspace is an inseperable part of the methoxetamine experience.
 
Being fairly experienced wiith methoxetamine, I know that tolerance builds. But I also know what I'm doing to myself and so if there were something that would allow a 5 or 10mg dose to be metabolised slower, it would be the perfect thing I'm looking for. At those doses I feel fairly comfortable in that dissociated headspace but the duration is not as long as I'd prefer.. I'd rather not have to redose multiple times a day because I've been there and it leads to future problems
 
Why would drug companies have any interest in putting a drug they can't patent through clinical trials?
 
the antidepressant effect of NMDA channel blockers is complex, there is the short term mood lifting effect which is probably dopaminergic, there is the longer term more powerful AD effect which is mediated through some different mechanism (probably through growth factors) and this effect persists long after dosing and long after the drug is detectable.

http://archpsyc.ama-assn.org/cgi/content/extract/67/11/1110


Using regular doses of NMDA channel blockers as an antidepressant is not only pointless it is very unwise, these are not benign substances they disrupt a lot of important neurological functions including short term memory, they also seriously impair motor function, you should not drive or operate machinery under the influence of even a low dose.

MXE as a prescribed antidepressant?
There is next to no chance of any of these old style NMDA antagonists making it as antidepressants, the side effect profile is not acceptable, neither is the psychosis caused by acute overdose or chronic overdose (dosing at a rate that is higher than the clearance rate) or just at random. MXE appears to have significant dose to dose variability and be rather unpredictable, like PCP in its effects. There is also not a single reason to assume that chronic use of MXE is any safer than chronic Ketamine use, which leads to permanent physical and neurological changes.
Finally MXE or any of the related aryl cycloheyxlamines will not make it as medicines because they are tarnished. They were put out into the RC market without first having been put through the legitimate channels so irrespective of their purported medicinal benefits they will be labelled as first and foremost drugs of abuse drugs without any recognised medical utility. They will then be banned. Once they are banned they will never be investigated as potential therapeutics it is simply too risky too bureaucratic and too expensive to carry out clinical trials with Schedule 1 substances. By putting these substances out into the RC market to make a quick buck, the people behind MXE and similar, despite their high minded words to the contrary have killed these substances and destroyed any future they may have had. Slash and burn.

People seem to be confusing the dissociative and inhibition reducing acute effects with the true AD effects, they are not the same at all. People who justify regular use as somehow being antidepressant are unlikely to actually be depressed, rather they seek a continuous drug induced altered state of consciousness which is not achievable due to tolerance and is inadvisable. MXE appears to be rather less effective than ketamine as an antidepressant in the irregular shock dose (insult) regime.

until it is banned MXE is a semi-legal novelty. It is not likely to be a medicine in waiting.
 
USA is not the only country in the world. your point that RC dealers have killed these substances is moot
 
vecktor's British IIRC. It's hardly moot, rich countries (basically, North America, Oceania and Western Europe) account for the vast majority of global pharmaceutical sales, if a drug is illegal in those countries (as substituted arylcyclohexylamines probably will be) then they ain't ever going to become medicines.
 
I think vecktor hit the nail on the head; antidepressants that produce psychedelic/dissociative/strong dopaminergic effects in "overdose" (i.e. LSD, AMT, cocaine, a few others I'm sure) and have erratic development of tolerance are just not marketable. A defining feature of many "modern" prescription drugs is their safety in overdosage, and the few unsafe drugs that are left have been grandfathered in or are used in critical situations (where few or no drugs exist) under the supervision of a physician.

Moreover methoxetamine is far less documented and from initial reports seems a lot more manic and unfriendly compared to the only arylcyclohexylamine with anything close to a certification for use in humans, ketamine. I would imagine it would work in a pinch, but coming out of methoxetamine anesthetia must be ... messy.
 
As stated above, methoxetamine is not potentially useful for depression in regards to NMDA action for a multitude of reasons. Far too "messy". Check out Glyx-13 and the like for current work already in phase trials...(it is vastly more "refined".. a Glycine site partial agonist)
 
and every one of you has missed my reason in making this thread: the social anxiety aspect. you have only torn apart the idea of methoxetamine being a potential candidate to act as an anti-depressant

i understand the reasons it wont become an anti-depressant medication now, thank you for those comments but now how about my 2nd suggestion? the reason i would use it as a self-medication.......

and of course a drug like this would never be prescribed consider its abuse potential. you guys automatically consider this idea a no-go and have failed to open your mind to the possibilities that could be if you were to think about them.

also you didnt talk about another main thing i asked which would be a type of substance then would make it extended release... i would rather dose methoxetamine once in a night, and a low and comfortable dose at that, rather than 3 or 4 times to keep a social buzz going on. i prefer this type of thing over alcohol.
 
Last edited:
Extended release methoxetamine would be an amazingly bad idea, especially in overdose.

Have you tried selective channel blockers like gabapentin, or dopamine reuptake inhibitors? (low dose methylphenidate/MDPV)
 
vecktor said:
until it is banned MXE is a semi-legal novelty. It is not likely to be a medicine in waiting.
Click to expand...

the reason why ketamine will be accessible for ages is because it is used as a medicine. if it wasn't there would not be such an easy to procure supply of high quality ketamine.

when drugs are illegal with no medicinal value their quality is much less certain on the black market
 
vecktor said:
the antidepressant effect of NMDA channel blockers is complex, there is the short term mood lifting effect which is probably dopaminergic, there is the longer term more powerful AD effect which is mediated through some different mechanism (probably through growth factors) and this effect persists long after dosing and long after the drug is detectable.

http://archpsyc.ama-assn.org/cgi/content/extract/67/11/1110


Using regular doses of NMDA channel blockers as an antidepressant is not only pointless it is very unwise, these are not benign substances they disrupt a lot of important neurological functions including short term memory, they also seriously impair motor function, you should not drive or operate machinery under the influence of even a low dose.

MXE as a prescribed antidepressant?
There is next to no chance of any of these old style NMDA antagonists making it as antidepressants, the side effect profile is not acceptable, neither is the psychosis caused by acute overdose or chronic overdose (dosing at a rate that is higher than the clearance rate) or just at random. MXE appears to have significant dose to dose variability and be rather unpredictable, like PCP in its effects. There is also not a single reason to assume that chronic use of MXE is any safer than chronic Ketamine use, which leads to permanent physical and neurological changes.
Finally MXE or any of the related aryl cycloheyxlamines will not make it as medicines because they are tarnished. They were put out into the RC market without first having been put through the legitimate channels so irrespective of their purported medicinal benefits they will be labelled as first and foremost drugs of abuse drugs without any recognised medical utility. They will then be banned. Once they are banned they will never be investigated as potential therapeutics it is simply too risky too bureaucratic and too expensive to carry out clinical trials with Schedule 1 substances. By putting these substances out into the RC market to make a quick buck, the people behind MXE and similar, despite their high minded words to the contrary have killed these substances and destroyed any future they may have had. Slash and burn.

People seem to be confusing the dissociative and inhibition reducing acute effects with the true AD effects, they are not the same at all. People who justify regular use as somehow being antidepressant are unlikely to actually be depressed, rather they seek a continuous drug induced altered state of consciousness which is not achievable due to tolerance and is inadvisable. MXE appears to be rather less effective than ketamine as an antidepressant in the irregular shock dose (insult) regime.

until it is banned MXE is a semi-legal novelty. It is not likely to be a medicine in waiting.
Click to expand...

Source? Fastandbulbous claims its more effective.
 
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