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Methoxetamine's Therapeutic Value

^Don't get me wrong, I respect your opinion hugely, but parents generally think that their children are the most beautiful of all.
 
If a drug is not approved by the medical community that does not prevent it from being used medicinally nor does it prevent any therapeutic value that drug might have, obviously. Countless RCs are used medicinally despite their lack of medical sanctioning and ambiguous legal status, so in that sense MXE is already an approved pharmaceutical helping those who need it.

As others have stated, MXE would not have been a good candidate for a widely distributed antidepressant anyway...as for MXE XR...I cant imagine anyone wanting it to last even longer.
 
To be honest MXE XR is a recipe for filling up psyche wards and occupying the police as progressively more and more people lose their shit after dosing. It's probably the reason PCP hasn't taken off either...
 
hamhurricane said:
If a drug is not approved by the medical community that does not prevent it from being used medicinally nor does it prevent any therapeutic value that drug might have, obviously. Countless RCs are used medicinally despite their lack of medical sanctioning and ambiguous legal status, so in that sense MXE is already an approved pharmaceutical helping those who need it.
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an interesting understanding of the term 'approved pharmaceutical' you have there,
 
KuSh Boii Whip said:
and every one of you has missed my reason in making this thread: the social anxiety aspect. you have only torn apart the idea of methoxetamine being a potential candidate to act as an anti-depressant

i understand the reasons it wont become an anti-depressant medication now, thank you for those comments but now how about my 2nd suggestion? the reason i would use it as a self-medication.......

and of course a drug like this would never be prescribed consider its abuse potential. you guys automatically consider this idea a no-go and have failed to open your mind to the possibilities that could be if you were to think about them.

also you didnt talk about another main thing i asked which would be a type of substance then would make it extended release... i would rather dose methoxetamine once in a night, and a low and comfortable dose at that, rather than 3 or 4 times to keep a social buzz going on. i prefer this type of thing over alcohol.
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Self-medication rarely if ever achieves anything. I used methoxetamine a few times per week, and have gotten shit out of it. My short-term memory is next-to destroyed, but slowly rebuilding. My motivation is gone along with the memory.

The people above know what they are talking about. Methoxetamine is not benign, and abusing it definitely comes with a price.

I know the feeling you're talking about - the way MXE helps in social situations. I guess it's easier to open up and talk, when your brain is half-way in la-la-land, and carrying a head full of dopamine.

It does help, you're absolutely right in that aspect. You simply can't be doing dissociatives every time you want to be social.. you can, but think of the consequences, man.
 
and every one of you has missed my reason in making this thread: the social anxiety aspect. you have only torn apart the idea of methoxetamine being a potential candidate to act as an anti-depressant
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The majority of recreational drugs will help short term with social anxiety.

MXE has about as much of a chance as being marketed as a social anxiety drug as cocaine does.
 
To be honest, I was just wondering what kind of substance could possibly extend the half life of the drug for my own reasons. I doubt it will ever make pharmacy shelves . This is simply for my own knowledge, did not mean to create a debate lol

I've binged on the stuff for a months time dosing multiple times a day and I know the downsides to the drug now.. I wouldn't doubt that I'm more knwoledgeable about this drugs potential than 99.5% of the population in my county. I have actually been through some shit storms because of the drug. So I do know what I'm getting into and this is simply experimentation.
 
One note regarding MXE as a potential anti-depressant-- most protocols utilizing ketamine as an anti-depressant require small amounts administered gradually over a length of time, with many sources (such as Jamshyd) commenting that large doses do not seem to work, or may actually be counterproductive.

It's possible that MXE (if it has any anti-depressant effect) could have similar limitations, so for folks who have tried it, please let us know something about your dosing regimen?

amanitadine said:
As stated above, methoxetamine is not potentially useful for depression in regards to NMDA action for a multitude of reasons. Far too "messy". Check out Glyx-13 and the like for current work already in phase trials...(it is vastly more "refined".. a Glycine site partial agonist)
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I'm amazed that a peptide drug like Glyx-13 is able to pass the blood-brain barrier.
 
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^
yes i was only planning on very minute, subtle doses of mxe administered at the same time or an hour after a type of compound inhibiting the metabolism of the drug.......

i have tolerance with this drug and it has a different kind effect after using it for a while, compared to your first few times giving'er a go
 
yes regardless of what you guys think. this drug definitely has potential to be an anti-depressant and to help with social anxiety.

speaking from experience.
 
i had a pretty good idea actually.... my plan is ill have a known amount of water mixed with a known amount of mxe and i can sip on it throughout the day... every 2 hours or so take a sip to take a 2mg dose or something.... would have to be aware of dose and time between doses but i think it could be something i may try
 
Fair enough. As long as you're conscious to what you are doing.
--

You could dissolve 100 mg of material into 100 mL's of water (e.g.) and then use a pipette system to control doses quickly and easily.
 
Okay... I know absolutely nothing about these research chems... I hear that MXE is similar to ketamine? The only time I used ketamine was in a very low-dose topical cream that I put on this super gnarly injury I have. (I also take opiates for Pain management, and this specially-compounded cream was by prescription)
I have since switched doctors since I moved, and am thinking that MXE may give me similar theraputic value? What do you guys think?
I would probably not make it into a topical cream and just take it (sublingual seems to be the best way???) when I dose with my Dilaudid in order to lower the amount I need and synergize for better analgesia.

Also I have found many conflicting reports on the legality of it in the U.S.A., even here on bluelight. Can someone give me a link or a solid answer on this question?
 
sekio said:
Extended release methoxetamine would be an amazingly bad idea, especially in overdose.

Have you tried selective channel blockers like gabapentin, or dopamine reuptake inhibitors? (low dose methylphenidate/MDPV)
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This is not to nit-pick with you or anything, but rather just an observation stemming from my personal experience. I think using MDPV regularly for anti-depressant / anxiolytic effect is absolutely unsustainable, and quite honestly, uneffective.

YMMV ;)
 
i see ketamine being valued in depression at LOW doses and not everyday, maybe once every couple days. the same may be for methoxetamine but it is an RC and so of course there is not nearly as much research done on it...if any.

im sure mxe is good for recreational use but thats not my bag so i aint gonna say anything more.....for now at least, hehe.
 
muvolution said:
Okay... I know absolutely nothing about these research chems... I hear that MXE is similar to ketamine? The only time I used ketamine was in a very low-dose topical cream that I put on this super gnarly injury I have. (I also take opiates for Pain management, and this specially-compounded cream was by prescription)
I have since switched doctors since I moved, and am thinking that MXE may give me similar theraputic value? What do you guys think?
I would probably not make it into a topical cream and just take it (sublingual seems to be the best way???) when I dose with my Dilaudid in order to lower the amount I need and synergize for better analgesia.

Also I have found many conflicting reports on the legality of it in the U.S.A., even here on bluelight. Can someone give me a link or a solid answer on this question?
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if you want to use the local anesthetic properties of methoxetamine then yes you can use it like you used ketamine's. it does well as a numbing agent in my opinion.

also about your legality issue, im not 100% sure i only heard about the analogue act affecting you guys in the United States... i don't even know if it affects ketamine because of its class.... i know some people dont like to ship to united states because of legal issues.
 
villian said:
The majority of recreational drugs will help short term with social anxiety.

MXE has about as much of a chance as being marketed as a social anxiety drug as cocaine does.
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You're right but cocaine generally helps for about 30-40mins and then the anxiety will increase.

A single dose of MXE (IME) will help for around 2 weeks and then will return to normal (no rebound) however I have not abused this drug, I doubt that would produce the same effects.
How likely is it that a once a month dose of MXE is going to be overly toxic? I wouldn't use it more than that for AD and anti-anxiety effects and even that is more often than I use it.
 
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