Opioids Novel analgesic, safe for use?

[DoctorNinja]

Ok so I was looking for a combination to provide 100% relief of my study migraines that doesn't involve euphoria opioids like oxycodone. So I made this type of capsule:

Ibuprofen: 500mg
Famotidine: 20mg
Codeine: 100mg
Caffeine: 100mg


I called it IBU100. So far provided 100% pain relief for a tough migraine I had after a 4h exam. Only tested it once, no apparent adverse effects. Personal experience:

Time 0min: Migraine is 8/10. Sounds, light and movement of the head is very painful, the pain is hardly bearable.
Time30min: Fast on set of the drug, starts at the back of the head. Pain is still bad but I feel better.
Time 40min: Pain is relieved 50%. Feeling better
Time 50min: Pain relief dropped to 20%, feeling bad again
Time 60min: Pain relief is now 75%
Time 70min: Pain relief went up to 90%
Time 90min: Pain relief is 100%

Does anyone know if this combination is safe for the use?

 

[blakmike]

You sir, can fend for your self! Congratulations!

As long as Famotidine doesn't have harmful interactions with any of the others I think it would be safe. I'm no chemist tho....

 

[sekio]

The codeine is a bit questionable because it's an opiate, as is your purported branding as IBU100 (just like 100mg ibuprofen pills everywhere).

If it works for pain relief, great, but don't expect the codeine-part of it to help forever.

For those too lazy to google it, famotidine is a H2 antagonist and wiki sez:

Unlike cimetidine, the first H2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs.

 

[ro0ga]

Ever consider trying a drug like Imitrex (sumatriptan), Maxalt (rizatriptan), or Zolmig (rizatriptan) to help with your migraines? Those aren't habit forming and seem to work wonders for people with migraines.

 

[NeighborhoodThreat]

I've had horrible migraines for about ten years now, and I've tried basically everything under the sun for them (including mushrooms and LSD, which is the best anti-migraine drug I've found so far)

Ever consider trying a drug like Imitrex (sumatriptan), Maxalt (rizatriptan), or Zolmig (rizatriptan) to help with your migraines? Those aren't habit forming and seem to work wonders for people with migraines.

I've used all three of these drugs (legally prescribed) for migraines and they're all effective against migraines, more effective than all but the strongest opiates if you ask me....only IV Demerol or morphine have been somewhat effective against migraines, the weaker oral stuff doesn't touch it.

I've found Maxalt (rizatriptan) to be the quickest-acting of the triptans, but now I use Treximet (which is sumatriptan and naproxen sodium in one tablet) because it works even better, the sumatriptan's vasoconstricting effects work very well with the NSAID effects of the naproxen to knock the migraine out.

 

[ro0ga]

I've had horrible migraines for about ten years now, and I've tried basically everything under the sun for them (including mushrooms and LSD, which is the best anti-migraine drug I've found so far)



I've used all three of these drugs (legally prescribed) for migraines and they're all effective against migraines, more effective than all but the strongest opiates if you ask me....only IV Demerol or morphine have been somewhat effective against migraines, the weaker oral stuff doesn't touch it.

I've found Maxalt (rizatriptan) to be the quickest-acting of the triptans, but now I use Treximet (which is sumatriptan and naproxen sodium in one tablet) because it works even better, the sumatriptan's vasoconstricting effects work very well with the NSAID effects of the naproxen to knock the migraine out.

While Treximent is a good drug, it's a very highly overpriced drugs because generic Imitrex (sumatriptan) is the cheapest triptan and naproxen over the counter is cheap as dirt....i'd recommend getting generic naproxen OTC and getting a script for generic sumpatriptan. Get naproxen seperately and then just take the two drugs individually...will yield the same results and save you a pretty penny.

 

[NeighborhoodThreat]

^My insurance covers Treximet

I have done that route as well, though. The bad thing about migraines is they generally cause me to start shoving pills down my throat trying to get relief. Naproxen is the best NSAID to use by itself or combined with a triptan, however.

Sorry to derail the thread a bit, OP...

 

[DoctorNinja]

Ever consider trying a drug like Imitrex (sumatriptan), Maxalt (rizatriptan), or Zolmig (rizatriptan) to help with your migraines? Those aren't habit forming and seem to work wonders for people with migraines.

Man insurance won't cover those and last time the bill was fked up haha, great drugs though

 

[DoctorNinja]

I've had horrible migraines for about ten years now, and I've tried basically everything under the sun for them (including mushrooms and LSD, which is the best anti-migraine drug I've found so far)



I've used all three of these drugs (legally prescribed) for migraines and they're all effective against migraines, more effective than all but the strongest opiates if you ask me....only IV Demerol or morphine have been somewhat effective against migraines, the weaker oral stuff doesn't touch it.

I've found Maxalt (rizatriptan) to be the quickest-acting of the triptans, but now I use Treximet (which is sumatriptan and naproxen sodium in one tablet) because it works even better, the sumatriptan's vasoconstricting effects work very well with the NSAID effects of the naproxen to knock the migraine out.

gee, I guess im lucky the weaker stuff works for me.

 

[NeighborhoodThreat]

^Be happy that it does, I'm a daily user of opiates and they do nothing to touch migraines (even before I had a habit/tolerance they didn't do anything).

Runs in my family though, I was basically cursed to have them from birth. Glad to hear that your setup worked for you, though

 

[DoctorNinja]

^Be happy that it does, I'm a daily user of opiates and they do nothing to touch migraines (even before I had a habit/tolerance they didn't do anything).

Runs in my family though, I was basically cursed to have them from birth. Glad to hear that your setup worked for you, though

I use opioids too, more or less on occasion because I'm too lazy to extract so it's usually when I catch a sinus infection. The migraine is just terrible back then so I just CWE 100mg codeine and take it for the pain. It gives me 5 hours space so I can extract 1000 T1 pills, boil down, evaporate and get like 7g codeine. At that point I'm basically painless for a very long time so I just go to the doctor and get an antibiotic.

I have obsessive compulsive disorder, I hate thinking that it can run out at some point so I extract more than I need. In April 2010 I ended up throwing 5g codeine down the toilet because it's been 2 months I wasn't using it and it was just sitting on my desk, making me risk possession charges for nothing. Now I'm really busy with final exams so my codeine use went up again.

 

[halfoz]

i'm definitely interested to look at non-triptan/non-opiod/non-beta blocker solutions to chronic migraine.

my wife gets them, and they disabling for her. as far as i've been able to tell, the source of the pain is impingement of the trigeminal nerve right before it enters the skull. imitrex, imitrex injection, maxalt, stadol shot followed by imitrex, physical therapy, strict food diary avoing trigger foods, all of this and she still gets them.

i love my wife dearly, and it kills me to see her in such pain. she's grown up being told she was faking her pain, or exaggerating it, so of course, there's a part of her that feels guilty for having them.

i would do ANYTHING to help my wife with her migraines. ANYTHING. Please post or pm if you have suggestions.

we've tried everything:

 

[NeighborhoodThreat]

See a neurologist...triptans, opioids and beta-blockers are the main treatment options available right now....at least as far as I know

 

['medicine cabinet']

^yup.

ive been getting migraines for the past 20 years. if i could have some kind of surgery to stop them i would lol....full lobotmy.

the triptan class of drugs work AMAZINGLY well to stop a migraine, but they are crazy expensive and are bad for your heart from what i have read. Ive been on just about everything for migraines...triptans, beta blockers, opiates, the only one i never tried was sansert which is some kind of ergot based medication. ive always heard that LSD and mushrooms were good treatment but i hate to trip, its too much for me.

valium has always worked wonders for me along with some kind of triptan. my fav is the imitrex nasal spray because i always get mine behind my left eye and i can spray into my left nostril and it feels like its getting right in there to stop it. take like 20mga of valium and i can actually fight thru it enough to not be bed ridden.

i actually had to go to the ER a few weeks ago bc i didnt have any meds and the pain was so severe i felt like putting a 230 grain bullet thru my head. was puking my brains out and they made me wait 4 hours for one lousy shot of immitrex.

ive always been of the thought that if you can find something that works well for your migraines, TAKE IT! because for people that have never had one, its not just a headache, its a full body thing where everything is too bright and too loud, and you are confusedand disoriented, i like to strap a belt around my head to try and reduce the pressure haha. i feel for ya's.

 

[NeighborhoodThreat]

ive always been of the thought that if you can find something that works well for your migraines, TAKE IT! because for people that have never had one, its not just a headache, its a full body thing where everything is too bright and too loud, and you are confusedand disoriented, i like to strap a belt around my head to try and reduce the pressure haha. i feel for ya's.

Yep. My last one I felt like shooting myself as well, I ended up banging my head against the wall and making my roommate give me a ride to the ER.

A migraine is not a regular headache. Don't let anybody tell you otherwise.

 

[ro0ga]

Yeah, I'm a sufferer of migraines as well since I was about 9 year olds (I'm 26 now)...it's part of the reason why I've continued to use opioids for as long as I have. Sometimes the sole reason for my opioid use isn't even to get high, it's to ease the pain of an awful migraine.

NeighborhoodThreat - definitely right about migraines not being just a bad regular headache...people who don't get migraines don't seem to understand that. They'll usually say something like, "oh come on man, so what you have a headache? Take some advil and come out with us." They don't understand that some migraines I've had are probably the single most debilitating pains I've experienced.

 

[NeighborhoodThreat]

"oh come on man, so what you have a headache? Take some advil and come out with us." They don't understand that some migraines I've had are probably the single most debilitating pains I've experienced.

Yep. What's worse is emergency room staff who think you're drug-seeking and don't believe that you're actually in extreme pain. Well of course I'm drug seeking, it feels like somebody is driving an icepick into my temples, ugh...

Anyway, back to the OP. If I were you, now that you've found a cocktail that works for your migraines, keep it close-by at all times. Nothing worse than getting a migraine when you're far away from your migraine medication.

 

[docbp87]

Do none of the butalbital combo drugs work for you? They are all available as generics, and are dirt cheap (generic fionicet/fiorinal, etc.). Combos of butalbital, APAP, ASA, caffeine, codeine, etc. are all out there.

As for triptans, many of them have coupons/vouchers available through the manufacturer's. Ask your doc, or check out their website, or try to get in touch with the manufacturer, or rep in your area. Many of them have copay cards, some even making the drug free in the end. Sumatriptan is pretty inexpensive on its own as well, if your insurance won't cover it. A regular old free rx discount card with a processor control of MSC would take 20% or so off the cash price likely, which shouldn't be much to begin with for generic Imitrex in tablet form. Only problem is the limits usually imposed on those by card, and insurance (9 every 30 days, or in some cases 9 every 23 days, or like 27 every 90 days... stuff like that)


Good luck dude. Your compound seems to make sense, and if it works for you, then stick with it.

 

[medic2789]

i'm definitely interested to look at non-triptan/non-opiod/non-beta blocker solutions to chronic migraine.

my wife gets them, and they disabling for her. as far as i've been able to tell, the source of the pain is impingement of the trigeminal nerve right before it enters the skull. imitrex, imitrex injection, maxalt, stadol shot followed by imitrex, physical therapy, strict food diary avoing trigger foods, all of this and she still gets them.

i love my wife dearly, and it kills me to see her in such pain. she's grown up being told she was faking her pain, or exaggerating it, so of course, there's a part of her that feels guilty for having them.

i would do ANYTHING to help my wife with her migraines. ANYTHING. Please post or pm if you have suggestions.

we've tried everything:

I took Topamax (topiramate) for three years. It does a great job of preventing migraines if you can deal with the side effects. I had paresthesias, couldn't drink soda (everything tasted flat) and eventually had hair loss (it can put your hair follicles into resting phase). At the moment, I take 10 mg nortriptyline every day. That's working well too. I haven't had a migraine since about two weeks into the nortriptyline. I stopped the topamax about six months ago and was having migraines at least once a week until I started the nortriptyline. While on the topamax, I probably had a migraine once every few months. Beta blockers aren't a good option for me since my BP is normally around 110/70.

The best med I've tried for acute pain is midrin (acetaminophen, dichloralphenazone and isometheptene) followed by prodrin (acetaminophen, caffeine and isometheptene). The tryptans tend to make my stomach very upset, but they do get rid of the migraine.