I'm wondering how being on a combo of SSRI/Remeron/Abilify would affect taking bk-MDMA. I'm currently tapering off the SSRI. I know MAOIs would be dangerous with any form of MDMA but SSRIs seem to pose little risk especially since Remeron is known for blocking serotonin syndrome. Abilify is a very atypical antipsychotic with unique action so I'm not sure how it would affect the picture.
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BDD Moderators: Keif’ Richards
Methylone with SSRI/Tetracylic/Antipsychotic
- Thread starter Amu
- Start date
Captain.Heroin
Bluelight Crew
I would not take RC's while on these medications.
sekio
Bluelight Crew
Abilify will neutralize a large part of your methylone experience. And SSRIs essentially ruin serotonergic drugs for a lot of people in a lot of cases while they remain in your system.
With Remeron on top of that I think that it would be unwise for you to take bk-MDMA because at best it's going to be a threshold experience and at worst it will cause you harm.
With Remeron on top of that I think that it would be unwise for you to take bk-MDMA because at best it's going to be a threshold experience and at worst it will cause you harm.
Just as a precaution or is there a specific negative drug interaction?
sekio
Bluelight Crew
There's several specific drug interactions. Like, all of your meds will interact. Every one of them.
Yeah I've heard SSRIs are toxic with MDMA, so I assume the same would apply with with bk-MDMA, but I'm going off that soon. Abilify might negate Methylone, but wouldn't Remeron prevent harm?
sekio
Bluelight Crew
It's a pharmaceutical dog's breakfast. I'm not even going to speculate on any interactions.
SSRIs &c are some of the most misunderstood drugs in the public eye. Studies with MDMA and SSRIs are even more highly variable but there's enough in the literature to make me say with confidence that you shouldn't take MDMA or any of its serotonin-releasing relatives (bk-MDMA, methylone, methamp, the aminoindanes) while on drugs that mess with serotonin reuptake.
SSRIs &c are some of the most misunderstood drugs in the public eye. Studies with MDMA and SSRIs are even more highly variable but there's enough in the literature to make me say with confidence that you shouldn't take MDMA or any of its serotonin-releasing relatives (bk-MDMA, methylone, methamp, the aminoindanes) while on drugs that mess with serotonin reuptake.
I've heard people saying different things about Remeron though, a few folks mentioned it here:
http://www.bluelight.ru/vb/showthread.php?t=385898
There was no conclusion to the above thread really. I've also read people taking Celexa/Lexapro with MDMA just fine but had (no effect / negative effect) when MDMA was taken with other SSRIs. The fact that Abilify might block the dopamine action of bk-MDMA might be a good thing, since it would remove the speedy feeling, but it might also remove euphoria, but that isn't a big part of the high anyway since it's more of a mood feeling.
Captain.Heroin
Bluelight Crew
As a previous poster has said, the effects of methylone would be diminished by your medications, possibly to a point where an increased dose of methylone would only bring about negative side effects without any increase in desired effects.
There could be negative drug interactions; have you looked at Abilify's binding affinity? This one drug alone looks like it would prevent methylone from working very effectively if at all.
sighhill
Bluelighter
- Joined
- Jan 1, 2011
- Messages
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^The Captain is correct about the diminishing effects. My wife take SSRI's and I would say half the times she has taking methylone (as well as buytlone and mephedrone) the effect was only slightly noticed. The first time this happened was with mephedrone. She had taken mephedrone a few times before and noticed she wasn't feeling it like she had in the past so she bombed some more.
I have noticed no matter if the effect is as desired or diminished, she becomes severly chemically imbalanced. THe following 3 days are no where near worth the chance of a good 3 hours.
I have noticed no matter if the effect is as desired or diminished, she becomes severly chemically imbalanced. THe following 3 days are no where near worth the chance of a good 3 hours.
Yeah there was a period of depression/anxiety following the above combo for me as well, however some reports say SSRIs can actually prevent neurotoxicity from MDMA, the main articles on erowid goes over that.