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  • BDD Moderators: Keif’ Richards

Opiates just arent for me :(

Yeah you may have a lack of opioid receptors, so it just flushes through your system without binding to anything, maybe your gut receptors. Do you have any bowel changes (aside from plugging)?
 
I was doing some research and i think my diet has alot to do with the opiate tolerance (including my benzo tolerance)

"The pungency caused by capsaicin and piperine is caused by activation of the heat and acidity sensing TRPV ion channel TRPV1 on nociceptors (pain sensing nerve cells).[7]
Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites.[8] In animal studies, piperine also inhibited other enzymes important in drug metabolism.[9][10] By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications.[9] Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.[11]"

http://en.wikipedia.org/wiki/TRPV#Activation_and_functions

sorry if the quote sucked i couldnt find the right option in the toolbar ;(
 
^Can you elaborate on this some? I'm having trouble seeing what you are getting at. I have no idea about the TRPV thing, but CYP450 inhibition is supposed to potentiate most opiates. I don't know about hydromorphone specifically.
 
All people are different. Some people simply do not get euphoria from certain drugs. I'd say about 35% of people truly are able to attain euphoria from opiates. Same goes with cocaine and meth.

As everyone else says, I say you're lucky. But what out for stimulate addiction. That can be a real bitch too.
 
What i gathered from reading the articles and a few google searches is that it increases your natural pain tolerance. Capsaicin causes a flood of endorphines and is a MAO-B Inhibitor. I think....keyword think that with the frequency that I ingest capsaicin that my threshold for pain is greatly increased, and now that being said i do have a high pain-tolerance. Im searching through my browsing history for the links (there are a ton to sort through) and ill post when i find them.
 
landocomando said:
What i gathered from reading the articles and a few google searches is that it increases your natural pain tolerance. Capsaicin causes a flood of endorphines and is a MAO-B Inhibitor. I think....keyword think that with the frequency that I ingest capsaicin that my threshold for pain is greatly increased, and now that being said i do have a high pain-tolerance. Im searching through my browsing history for the links (there are a ton to sort through) and ill post when i find them.
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A high pain tolerance doesn't mean a high pain killer tolerance. I don't take opiates for pain killing, I take opiates for the mental goodness.
 
true. 'tis what i derrived from hours upon reading but i could be wrong like many times before.
however it doesn't change the fact that i dont get high :(
 
Hey everyone. I'm new to this whole forum thing so I hope I'm doing it right but I love to bang roxycontin and I've been put on suboxone. Can I bang it? Was told it will put me in immediate withdrawal. Is this true ? Please help me out
 
there are two sets of two different genes that we all have that allow us to process opiates. the first set is used to convert the non-morphine type opiates into a morphine type opiate. if you are lacking one of these, you will not convert very well, or at a slower pace. because of this, those that are missing the first gene will get little to no effect from non-morphines, these same people will also experience nausea at times. if lacking both of the first 2 genes than these people are essentially incapable of taking the first class, this includes vicodins, norco, codeine, etc.

People that are lacking one gene from the second set, are unable to use the converted substance efficiently, thus they need large doses. I.E. non opiate tolerant individuals have been seen to take what would be a toxic dose of morphine in most people and receive almost no analgesic effect due to their ability to process the morphine effectivly. Also, these same people will have issues with serotonin as these same genes play in there as well.

If a person is lacking in both sets of genes, than they can have a wide array of issues that most users never encounter. Likely we have all encountered them, they just get nothing from opiates, or do not like what they get. there is no way to tell if you are one of these people. There are also people that possess extra copies of these genes, they also have varying reactions, likely they will be very sensitive or eliminate the drug immediately as these same genes play into elimination as well.

Good luck, be safe out there.
when you excercise a little self control, you can do your shit for ever.
 
you may, but likely you will just go into DT's. If you got the Sub. to quit, good luck. If you need some other tools to help you through with DT's PM me and Ill give you some ideas
 
i am an opiate addict and one thing i noticed is that over the course of 2 years im still finding new parts to the opiate high. i think it takes doing a drug many times to achieve the effeects one is looking for.
 
blindman said:
there are two sets of two different genes that we all have that allow us to process opiates. the first set is used to convert the non-morphine type opiates into a morphine type opiate. if you are lacking one of these, you will not convert very well, or at a slower pace. because of this, those that are missing the first gene will get little to no effect from non-morphines, these same people will also experience nausea at times. if lacking both of the first 2 genes than these people are essentially incapable of taking the first class, this includes vicodins, norco, codeine, etc.

People that are lacking one gene from the second set, are unable to use the converted substance efficiently, thus they need large doses. I.E. non opiate tolerant individuals have been seen to take what would be a toxic dose of morphine in most people and receive almost no analgesic effect due to their ability to process the morphine effectivly. Also, these same people will have issues with serotonin as these same genes play in there as well.

If a person is lacking in both sets of genes, than they can have a wide array of issues that most users never encounter. Likely we have all encountered them, they just get nothing from opiates, or do not like what they get. there is no way to tell if you are one of these people. There are also people that possess extra copies of these genes, they also have varying reactions, likely they will be very sensitive or eliminate the drug immediately as these same genes play into elimination as well.

Good luck, be safe out there.
when you excercise a little self control, you can do your shit for ever.
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As above I thought the same way when reading your posts and thought you may have a genetic defficiency for metabolising these 'pro' drugs. 'Pro' drugs get their name because the metabolite is more active than the original drug, ie codeine is demethylated into the more potent morphine by the liver, this morphine then causes the effects you feel (most of them, not the itch).

For this reason I think you should try straight morphine if you can get your hands on it. Unfortunately I don't have amps anymore and have to rely on mscontin (which I think it pretty crap compared to oxy) but for you it may be better for those reasons (i.e. morphine isn't a pro drug).

Now before anyone cries foul about morphine not being a pro drug it is true that in the last 3 or so years they have found that morphine is possibly a pro drug for its sugar morphine-3-glucuronide (inactive) and morphine-6-glucuronide (more active) however without going into details if you lack the enzymatic efficiency to break down the other drugs you would be extremely unlucky to have the same problem with morphine. Different system really.

Otherwise as others have noted you may be defficient in the u-opioid (mu) receptors. In that case you're just plain fucked.
 
landocomando said:
Finnaly i actually hear someone doing the same opiates with me with the same negligible effects. (also yet to try oxycodone/oxymorphone) Dilaudid (8mg; repeated 2x) and Hydrocodone (45mg; single dose) (both in Norco and Vicodin) were not felt, even after dosing with a selection of pills (soma and xanax) from a "pharm party".

It mystifies me how the individual body chemistry can make such differences in effects from drugs. Including why such irresponsible combinations have not resulted in at least impairment greater than what 2-3 shots of 80 proof alcohol would do to me.

Have any studies been conducted on those with naturally occurring opiate tolerances and why no euphoria is experienced?
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Yep, I took 30mg hydrocodone and felt nothing, which is still a really high dose for no tolerance. Really odd. 2-3 shots of any alcohol would do more to me than 16mg of dilaudid. Idk how you took your D, but `16mg plugged is a crazy amount, I talked to another member on here who said he had a high opioid tolerance, and he said that 4-8mg up the ass would get him flyin high. He told me it takes him 80-90mg of oxy to get high. So It just surprises me that I didnt feel much off of 16mg. But hey, who needs opiates anyway??
 
i got offered 10mg oxys today. contemplating if i should buy them, i dont want to waste any money on a possibly nonexistent experience
 
theotherside26 said:
I know this isn't the answer you are looking for, but take it from a long term opiate addict...take this as a blessing. If they aren't "doing it for you" then I say you are a blessed person :) Opiates invite you in and can suck you dry all within a year.
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I will have to agree with TOS on this one. I was addicted for 8 years going on almost 5 years sober. The suckass thing is I am having surgery in a few months and have no idea how I am going to control my pain.

If you want to get fucked up go do something other than opiods.....

I can still party and get high but I don't get addicted like with the opiates. So really this is a blessing in disguise.
 
likeakite said:
If you cant ride the White Tiger, dont. You will only get hurt.
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And tigers are bloody hard to ride!

But seriously, as TINK stated, it is fucking addictive. I went fine for the first 2 years thinking addiction would never get a hold of me. 3rd year has done me over, now I take oxy everyday and hardly get high, more just to maintain my new 'normal' state. So for all those who read this remember just because you may not be currently addicted doesn't mean you won't be addicted down the track. Pull out if you see early signs (see other posts for the signs).
 
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