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DOC-NBOMe HCL

nuke said:
You'll get more out of it by hydrolyzing the amine, as it is it's probably not very active, I'd guess 3-10mg would be an active dose. I'd be cautious, as always, though.

The better one which is probably orally active is gotten by methylating the alpha position on the non-phenethylamine moiety...
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Reducing, you mean. Reducing agents will cleave off the benzyl group.

The NBOMe-amphetamines proved not to be very interesting or potent, I'm afraid.
 
"proved" in what way?

Time will tell. Or will YOU?

I am a student of chemistry:) So much too learn<3

And CERTAINLY ofcourse! if I have this one, I cannot be the first to try it... ?

But the guesses? as to this and that...

Interesting
 
^This.

Do We not know where the path leads until its been walked? eh?

I tasted it. A human:)

Anyways, 500mcg is next...
 
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You are already up to that level? I'd be careful with the rate of increased dosage, there. What if in the process of doubling dosage, you jump over the range between threshold and strong experience entirely, into "way too strong of an experience"? Given the steepness of the dose-response with some phenethylamines at some dosages, this is actually an important concern.

All that said, animal experiments suggest that you're still in the zone of likely inactivity, but there are been various surprises before.

ebola
 
urbansquatch said:
Its about time! When the time is right, you know. I Am determined to find out! Assuming the 1/10x DOx figure is true I will get there in good time, I intend to find out if no one else will before me, I'm working with what I got! Plan to confirm what can be, with what I have! Going shulgin style ofcourse, building my way there. Look forward to finding where this goes for me, for us!!! Will share ofcourse..!!

Comments? Anyone else, Anything?
<3
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Correct me, if I am wrong, but didn't Erny said: "NBOMe amphetamines are about ten times weaker than their phenylethylamine counterparts.", i.e. potency of DOC-NBOMe should be 10 x potency of 25C-NBOMe and not 10 x potency of DOC.

Just a clarification, it won't be nice if someone will find this thread and use your post for dosing 20-40 mg.

Anyway, good luck with your research.
 
atara said:
Reducing, you mean. Reducing agents will cleave off the benzyl group.

The NBOMe-amphetamines proved not to be very interesting or potent, I'm afraid.
Click to expand...

Yes, I am fail at organic chemistry. I am thinking of amides
 
I wonder how NBOMe-phenethylamine (yes, the 'bare skeleton' PEA) would act in vivo.. would it still be as inactive as PEA, or would the addition of NBOMe shed the effectiveness of MAO-x, so that PEA would actually have activity?

Just wondering due to the PEA = effect / alpha-methyl-PEA = no effect statements on the previous page...


--

btw, just to be a dick: It is HCl, not HCL. (@ topic title)
 
allium said:
Correct me, if I am wrong, but didn't Erny said: "NBOMe amphetamines are about ten times weaker than their phenylethylamine counterparts.", i.e. potency of DOC-NBOMe should be 10 x potency of 25C-NBOMe and not 10 x potency of DOC.

Just a clarification, it won't be nice if someone will find this thread and use your post for dosing 20-40 mg.

Anyway, good luck with your research.
Click to expand...

Key word being weaker. So, If that broad statement is correct, than one might find the necessary dosage to be 20-40mg. Key word being might. :)
 
Repulse said:
I wonder how NBOMe-phenethylamine (yes, the 'bare skeleton' PEA) would act in vivo.. would it still be as inactive as PEA, or would the addition of NBOMe shed the effectiveness of MAO-x, so that PEA would actually have activity?

Just wondering due to the PEA = effect / alpha-methyl-PEA = no effect statements on the previous page...


--

btw, just to be a dick: It is HCl, not HCL. (@ topic title)
Click to expand...

And on that note , I've been curious what the N-Benzyloxy would do to 3,4 Methylenedioxyphenethylamine........
 
amanitadine said:
And on that note , I've been curious what the N-Benzyloxy would do to 3,4 Methylenedioxyphenethylamine........
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It might very well be dangerous looking at the N-methyl:
http://www.bluelight.ru/vb/showthread.php?t=561785

Anyway the beauty of MDMA is the complete set of pharmacology which is complex right? And 25X-NBOMe's seem to be pretty selective.
Assume for a second that one would find an MDMA analogue with a certain N-substitution with benzyls or THF structures in them and what not... and it would also become very selective (or not) but a releaser and/or it fucks with the SERT. Isn't that asking for a potent chemical weapon to induce serotonin syndrome? Or in the case of dopamine and other monoamines: mania / stim psychosis etc.
 
n-BOMe or n-BOH substitutions should do anything remotely similar to n-methylation for most any phenethylamine.

Assume for a second that one would find an MDMA analogue with a certain N-substitution with benzyls or THF structures in them and what not... and it would also become very selective (or not) but a releaser and/or it fucks with the SERT. Isn't that asking for a potent chemical weapon to induce serotonin syndrome? Or in the case of dopamine and other monoamines: mania / stim psychosis etc.
Click to expand...

Thus far, n-ring substitutions on phenethylamines have only resulted in increased selectivity and affinity for and efficacy at 5ht2a, with the exception of DARIs similar to MDPV.

ebola
 
In this case, I suspect the compound will be active around the doses of 2C-E, with probably shorter duration than DOC, and possibly being more transparent on the body with unique psychedelic effects.

Just a guess. But lowered potency compared to DOC certainly doesn't make it not worth exploring. DOC is a great trip on its own, better than any 2C-x in my opinion. So I hope to see some more research on this chemical.
 
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