MDMA and COCAINE?

[SWDRJuggalo]

if ur gonna do it do the yak after the mdma is wearing off otherwise dont combine

 

[delta_9]

Is it true cocaine kills your roll?

This may have already been stated (apologies for not reading this entire thread), but cocaine and mdma are pharmacologically incompatible. Cocaine has a higher affinity for the SERT than mdma, meaning if you've done cocaine before mdma, while the cocaine is sitting in the SERT it will block mdma from 'doing it's thing'.

Are they dangerous to do together?

They can be dangerous to do by themselves

 

[ice-zephyr]

In my experience, and not saying its typical or to be expected by any means, Coke+E didn't cancel out either experience. I've done it probably 10 separate times and based on those experiences, they potentiated each other for some odd reason. Like a super stimulated roll, but without a major enough decrease in the empathogenic(sp?) feelings to make it not worth my while.

The time i did like a .5 with a pill, which was my first time doing coke, my heart was beating so hard that I was scared, except listening to Pink Floyd in the dark chilled me out and made it one of the most euphoric feelings I've ever had.

Of course it is a waste, though, just like all use of cocaine, in my opinion lol. I'd much rather just smoke a sack of crystal if i wanna be up haha.

 

[MasterSplinter]

Coke blocks sertonin receptors MDMA releases a shit ton.. So yes it domiantes your roll and kills it dead

so if you took more beans wood that re-unblock the recepters for more serotonin flow?

 

[nefariouscaine]

so if you took more beans wood that re-unblock the recepters for more serotonin flow?

Thats a double sided answer at best

The issue with that is each persons receptors reacts differently but it would more directly relate to what the individuals halflife for blow & at what point in time it was no longer blocking the receptors

could it work - yes, on some

is it likely to work on all in what i'm thinking might be your question - ie already "rolling" doing a few lines & then popping another bean basically right after - no, I wouldn't imagine this would work on most at all but people have different chemistry so someone might have a very short halflife for caine

the caine wouldn't have had time to work out of the system and would still be very effective at blocking those receptors you're looking to open even with the reintroduction of further mdma

unblocking would in effect need to come in the form of something that would actually unblock those receptors which mdma does not - it just acts as a catalyst to play on those receptors