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Bupe Sub "Priming" Daily dosage experience

jctoona84

jctoona84

Bluelighter
Joined
Jun 30, 2010
Messages
87
Location
pa
I have noticed this for awhile, but I always forget to post it. I call it sub "Priming"...just like priming a lawnmower engine.

I have found that when I first wake up and take a really small "priming" dose of sub rather than a regular or high dose that the effects throughout the day are better.

I dose 3-4 times a day totaling 1-2mg by days end. If I take a regular or high dose in the AM I don't feel the effects from redosing later in the day. In fact I feel kinda like crap.

When I take a small primer dose in the am, followed by a regular dose a few hours later the effects are much more pleasant for the remainder of the day with further dosing. This also conserves the amount of sub I go through.

Just an observation.
 
This will be closed because it's not the place for observations, but I think that most people would agree with you that subs are in all respects better at the lower doses. I certainly do.

S
 
^ya pretty much........

i also agree with a low dose.....i am back on a 1mg dose in the am, and could not be happier.......high doses make me feel like shit.
 
suessmayr said:
This will be closed because it's not the place for observations, but I think that most people would agree with you that subs are in all respects better at the lower doses. I certainly do.

S
Click to expand...

Whoops, sorry about the misplaced thread.

I would love to find out exactly why they seem to feel better at lower doses. At first I thought it would be the naloxone, but after further research it seems like the naloxone doesn't really do anything if combined with bupe.

I wonder if the larger doses just saturate everything and do not allow for other natural chemicals to bind, making it unpleasant/overwhelming.
 
From what I can tell, the naloxone is only in there to make the DEA sleep better at night, due to buprenorphine's higher affinity for the receptors in question, the naloxone is pretty much filler.

What I've noticed with subs is that less is more. Granted, I have limited experience with them, compared to others on this board. Buprenorphine is a partial mu-agonist while its active metabolite, norbuprenorphine, is a full mu-agonist. Most people who use opiates find the full agonists to be the fun ones (think morphine, hydrocodone, oxycodone, fentanyl, all the opiates you think of when you think of "opiates"). However, there is a certain dosage where the buprenorphine actually blocks its own active metabolite, just like it blocks the naloxone.

That may be why you're feeling worse with higher doses.

Just wanted to chime in there, I'm no bupe expert but since only a few other people have replied I figured I would throw my opinion in.
 
The only tricky part for me when taking low doses is i can get high after a week or two.Its no prob for me to get thru the day wit only takin .5mg or even less a day.After aweek or two tho i know i can snort 1 or 2mg and get high so its really hard to not do that.
It took me a long time to realise this.I just happened to be clean for 3 weeks last year of evreything inlcluding suboxone.Then one day my boy just had like a 2mg line on the table so i took it n i got sky high.
But ya less is more 4sure.Alot of ppl dont realise that in europe subs come in .2 and .4mg pills.I think thats enough proof to show that people do not need fucking 32mg a day thats crazy i think anything over 2mg a day is alot.
About the redosing thru out the day i can see that making me feel better but i would also think it would make the w/d alot worse when you're ready to come off.
So due to that i try to only dose once a day in the AM.
I just really gotta fgind a way to not get high and the only way to do that is to stop the sub's completly which i am currently working on AGAIN!!.Its goin good tho im happy :)
 
I agree, 32mg is an insane dose. I take 0.5 - 1.0 mg and I'm balls high, 2.0mg and I'm just as high as I was with 1mg, just more side effects, so I think it's the norbuprenorphine getting knocked out of the those good receptors.

This will probably get merged with the Suboxone Megathread since it hasn't been closed yet :)
 
Im sorry that is what i ment by the .2 and .4mg pills i thought they give that out for getting off opiates also.

My whole angle of my post was towards a quick suboxone detox like a week or two.I dont know much about maintenance.

That is why im scared of redosing thru out the day because i dont plan on being on sub's for a long period of time.So i am always trying to take as little as possible only once a day.

When i said i get high i ment if i take .5mg subs a day for a week str8 and make sure never to redose after about a week i can sniff 2mg of subs and get really high.

I feel like that really sets me back cuz thats usually my last dose and im headed towards sobriety.

I usually dont last long im obviously doing somthing wrong.Im sure the right thing is to try maintenance for alittle while but im a chicken.

Im just gonna keep trying it this way untill hopefully one day it all just clicks in my head and i will stay sober.

I can let you know how it goes this time i will take my last piece of sub on sunday.This time i have a bet tho that i am not willing to loose and its a long term bet that i also cant afford to loose.

So im hopeing i will actually stop and actually stay off the subs this time.I think im gonna do it this time i said that last time about dopeand i really stayed off the dope for a while allready now its just the subs i keep pushing off.
 
I agree that 32mg is not going to gain any more positiv effects than 24mg. (And so doesn't my doc)

But I can tell you guys this, I don't agree on that less is more philosophy.
If i take smaller doses I start to crave heroin and get very uncomftorable, but then Bupe does not hold me very good at all.
 
I never thought about the "norbupe" effects. That sounds like the most plausible explanation to me thus far. Thanks!

Edit...

Also, I can't even comprehend a 32mg dose's effects. I've done 8mg in one dose a few times when I wasn't as informed about bupe. It lasted 36+ hours, but wasn't pleasant by any standard.
 
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