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☛ Official ☚ The Big & Dandy Ibogaine/Iboga Thread

Ibogaine's a 5HT3 antagonist right? Well, it's thought to do a bunch of other stuff too, but I can attest to a 5-HT3 antagonist's ability to temporarily mask withdrawals (opioid w/d at least as that's what I was going through).

I had an old script of ondansetron (zofran) and took some to combat the nausea brought on by opioid withdrawals from poppy tea. Not only did the ondansetron help with nausea, but it made me feel considerably better for at least several hours. Back then, I just attributed it's benefits to easing nausea only, but after reading several reports claiming 5-HT3 antagonists' role to ease withdrawal symptoms, I became convinced there was something to this. Upon reflection, I realized that zofran obviously didn't just help with nausea.

This is the correlation between ondansetron and ibogaine. However, Ibogaine does something else by not only masking the symptoms but permanently alleviating them as well. Perhaps if one took ondansetron continually at higher doses it would prove effective...similar to how people have to take considerable doses of Ibogaine to rid them of their afflictions.

Anyone have experience using 5-HT3 antagonists to mask withdrawal symptoms?

It's been about a month since taking Ibogaine. I don't know if it was due to the cessation of effexor or the opioids, but my hormones were totally out of whack. I was like Robert De Niro in Analyze This. Anyway, I've had great success with Tongkat Ali. It has helped me feel like me again. I want to blame effexor for fucking with my hormones, but alas, I don't know. Tis a nasty drug, that venlafaxine.

I'm surprised there's not much activity on this thread. Utilizing Iboga for whatever reason is revolutionary...well it was for me.
 
just wanted to chime in and say the Ibogaine IS out there... in the US there is most definitely an "iboga underground", and it's growing quite rapidly.

iboga didn't save my life, it gave me the ability to finally do it myself.

5 years of IV heroin addiction washed away like a bad dream.
 
Divine Winds said:
ill do so soon, and i should have a new report in the near future, im going to try an extract this time instead of just the ibogaine.
and for now, heres a bunch of experiences:

http://ibogaine.co.uk/experience.htm

great site...


p.s. hope you guys liked those vids. i was thinking of making a thread to post video links-ive got tons! all kinds of psychoactive subject matter...
maybe someone out there has one i havent seen!
whatcha think?
Click to expand...

wow. caroline's story.... i wonder what other psychedelic drugs have been shown to render the most healing effects from childhood/supressed trauma...
 
18-Methoxycoronaridine

I think Ibogaine does work at the right doses, and can give addicts a good window to change their addict lifestyle, but by all accounts I've read, it's not a "forever" cure. It only lasts as long as the metobolites remain in the body/brain, which can be months. After that the user has to remain committed to the changes they've hopefully made towards remaining drug free.

To me the real "cure" lies with the ibogaine analogs that have been synthesized: 18-Methoxycoronaridine, 18-MAC, and ME-18-MC. All of these chemicals have shown to have the anti-addictive qualities of ibogaine without any of the side effects (hallucinations, etc, check out the PubMed articles, they're fascinating). In other words, they could one day be developed into medicines that could be administered to get the person off drugs without w/d's and then repeatedly administered as needed to keep the individual clean, without any harm to the person. Unfortunately clinical trials never got funded in the mid 2000's and these substances remain untried in humans. It is interesting to note that in Jan of 2010, 18-MC was licensed to a RC'er and became available to the general public (it's sold on their website anyway). Whether someone is willing to plop down the $600 they want for it and be the first (known) human subject, time will tell, and one day we may know for sure that 18-MC is everything it's said to be (a safe, non-toxic, non-hallucinogen, anti-addictive substance).
 
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Shockra said:
I think Ibogaine does work at the right doses, and can give addicts a good window to change their addict lifestyle, but by all accounts I've read, it's not a "forever" cure. It only lasts as long as the metobolites remain in the body/brain, which can be months. After that the user has to remain committed to the changes they've hopefully made towards remaining drug free.

To me the real "cure" lies with the ibogaine analogs that have been synthesized: 18-Methoxycoronaridine, 18-MAC, and ME-18-MC. All of these chemicals have shown to have the anti-addictive qualities of ibogaine without any of the side effects (hallucinations, etc, check out the PubMed articles, they're fascinating). In other words, they could one day be developed into medicines that could be administered to get the person off drugs without w/d's and then repeatedly administered as needed to keep the individual clean, without any harm to the person. Unfortunately clinical trials never got funded in the mid 2000's and these substances remain untried in humans. It is interesting to note that in Jan of 2010, 18-MC was licensed to a RC'er and became available to the general public (it's sold on their website anyway). Whether someone is willing to plop down the $600 they want for it and be the first (known) human subject, time will tell, and one day we may know for sure that 18-MC is everything it's said to be (a safe, non-toxic, non-hallucinogen, anti-addictive substance).
Click to expand...

I read a few reports saying that the trip was in actuality essential to the whole cleansing process. They were saying how without the trip you do not actually face the problem which is the addiction. I am looking for the report now on Erowid but I can't seem to find it, when I do I'll post back.
 
Yea, I think the trip may help, but the whole idea with ibogaine & 18-mc is that the user no longer craves the drug. And while i know humans are diff than mice, the mice who were given a single dose of 18-mc "chose" not to return to their DOC for a period of time, just like (and similar in duration to) ibogaine, but w/out the hallucinations. The trip was not essential to the abstinance. It just happens that ibogaine effects an area of the brain that deals with addiction, and also causes hallucinations via a totally diff pathway (the serotonin transporter, which 18-mc does not effect), but the two actions don't appear to be scientifically related to ibogaine's ant-addiction activity, just a case of one substance doing more than one thing. Again, do i think the re-inforcement of the trip helps, yes I do, but only because ibogaine can be a rough time, with multiple re-dosing often not practical, hence that re-inforcement comes in handy over the long haul. But given that fact that 18-mc does not appear to cause hallucinations, and is non-toxic, it could be re-dosed as often as needed, hence the abstinance effect of the trip isn't all that relevant to begin with, you know?
 
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^ That sounds a bit western and rich ($$) of a solution, no?

How about the seeming want of those with the full experience to change themselves, not just seemingly feel a drug induced difference as long as it is as permanently scripted. (I think both options should ideally be available, but let's not trick a public into the long term stockings of big pharma.)
 
I'm not addicted to anything but I'd love to give ibogaine a whirl just as a psychedelic drug. Judging from it's receptor affinity profile it's a wild animal. I want to don my keta-boots, hop on and ride the thing and have it buck me off in the back woods of my brains, but it seems like the price is so high because it's marketed as a one time thing for addicts. Yet, really, it's just another herbal extract. It grows. You don't even have to synthesize it, just live in a country where the plant is legal. Grow it, extract it, and bingo bongo you're everyone's new best friend. Illegal or not, the stuff ought to be cheaper and easier to get than it appears to be.
 
jstb0b said:
Ibogaine's a 5HT3 antagonist right? Well, it's thought to do a bunch of other stuff too, but I can attest to a 5-HT3 antagonist's ability to temporarily mask withdrawals (opioid w/d at least as that's what I was going through).

I had an old script of ondansetron (zofran) and took some to combat the nausea brought on by opioid withdrawals from poppy tea. Not only did the ondansetron help with nausea, but it made me feel considerably better for at least several hours. Back then, I just attributed it's benefits to easing nausea only, but after reading several reports claiming 5-HT3 antagonists' role to ease withdrawal symptoms, I became convinced there was something to this. Upon reflection, I realized that zofran obviously didn't just help with nausea.
Click to expand...
I've never had to withdrawal from anything, but I use ondansetron to get rid of psychedelic nausea. There's definitely something to the 5-HT3 antagaonism and interactions with other drugs that affect serotonin. I've not experienced any interactions with 5-HT psychedelics, but with DXM, a serotonin reuptake inhibitor, I have notice a strong interaction. It's probably my favorite combination of all time actually. I get a sense of high euphoria and lucidity from it, and qualitative effects far different from DXM on its own. Others who have tried it haven't been as lucky, but some of them have experienced some interaction, though the results were more neutral. In any case, ondansetron is certainly good stuff.
 
nopipesdfw said:
^ That sounds a bit western and rich ($$) of a solution, no?

How about the seeming want of those with the full experience to change themselves, not just seemingly feel a drug induced difference as long as it is as permanently scripted. (I think both options should ideally be available, but let's not trick a public into the long term stockings of big pharma.)
Click to expand...

From my research into ibogaine, a significant number of ibo users who have the "full experience" do come off the trip wanting to change themselves and remain drug free as you say. And a big reason why they are initially able to do this is because ibogaine metabolites remain active in the body/brain long after the trip is over. But once the metabolites are no longer active, the person is pretty much back to pre-ibogaine status in terms of cravings and such. At this point, the one's who have made the necessary lifestyle changes etc., seem to be the one's who continue to remain drug-free. Those who have not, seem to be the one's who relapse at some point after the ibogaine and it's metabolites have completely left the body (and even before).

And so it is often suggested that ibogaine may need to be given every six months or so to keep the user drug free and free from cravings. Given the harsh nature of an ibogaine trip though, who wants to do that? Hence, re-dosing with 18-mc would seem more practical. Similar to ibogaine re-dosing, it may only be needed as little as every six months or so. And this is the reason why big pharma hasn't wanted to develop 18-mc (and ibogaine-though the hallucations have something to do with that too), as it wouldn't be very profitable if it was only needed to be taken bi-annually or whatever. So if 18-mc ever does make it to market, I wouldn't be too worried about big-pharma. I'd just be glad addicts had access to it if they wanted it.
 
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I have never tried Ibogaine to see just how powerful this medicine is,but from what i have read and heard along the way it seems to be THE ONE for healing on all levels.

I know Ayahuasca is the medicine that every one goes on about these days and is becoming quite popular for facing your self,but Ibogaine i think must be the best for this.

If any one out there has used both for healing purposes could you say which one of the two brings about the most profound life changes.

Is Ibogaine the most powerful.I know the Bwiti people have a name for Iboga that roughly translates as "the one that cracks open the head".
 
So many questions to answer...

No you cannot take Ibo if you have any heart condition.. people have died from not being honest with theyre provider.

Liver problems are also contraindicated, although there is some evidence it can lower HCV viral load.

Ibogaine HCL is synthesised from vocanga

A psycho-spiritual dose for an opiate naieve person is around 10mg/kg (TA/HCL)
Opiates patially block its effects so opiate addicts need around 19mg/kg

It can potentiate opiates too hence the death of the french woman who used heroin the day after Ibogaine.

It works on multiple levels, 'resetting' dopamine/serotonin receptors whilst kicking opiates off and holding off withdrawals.. it does work, i've done it.

It stops cravings and PAWS if boosters are taken as required

Kratom works in a similar way, also salvia

It's not something to be messed with, it's a serious spiritual journey and some people find it too much

It cant be injected, its taken orally, as powder or in caps, it causes nausea in high doses so can be taken rectally.
 
It can be very dangerous to mix any psychy meds with Ibo, luckily I dont take any,ore but I even had to stop my omeprazole five days before.

Ibo is not someting you would want to take recreationally, you have to lay still, you become photo and audio phobic, and ataxic, you wobble all over the place.

Its like recovering from a general aneasthetic, it took me five days to feel 'normal'

I didnt smoke a cigarette for a week, and when I did it tasted AWFUL... it definately does something to nicotine receptors.

Booster doses for PAWS and cravings can be taken months after when needed.
The difference is you dont take a huge flood dose like for a detox.
600-1000mg daily or as needed (root bark) is enough to keep most people clean.

At this dose you wont get any halluicinations, maybe a bit of buzzing in the ears and lights flashing in the corners of your eyes.

It wont cause insomnia like a flood dose does. But it will stop cravings.

I take a dose of root bark as required. My PAWS lasted months last time I detoxed (14 year heroin/methadone habit)

Ibo does seem to work better for people with short acting opiate habits, with a heroin user with a short habit (1yr or less) One dose is usualy enough, they dont even need boosters in the days after sometimes.
Whereas a long term user may need up to three treatments and boosters for months after.. (it usually takes the brain about 6 months to start naturally producing dopamine/seratonin again. Ibo speeds up this process.
 
I've never done dmt so I can't personally compare it to ibogaine, but the guy I was in constant contact with considered ibogaine the 'granddaddy of all hallucinogens.' He had quite a bit of experience treating people w/ ibogaine and had lots of experience in the field. The hallucinations brought on by ibogaine are probably just as effective as lsd or dmt. However, it would seem to me that ibogaine would be more ideal as it brings up tons of old memories. Hell, I could play piano like I never quit after taking ibogaine. I remembered old songs that I used to be able play 4 years prior.

18-mc seems very appealing to me as the ibogaine trip KICKED MY ASS. The trip was fun; really fucking fun actually. I remember thinking 'holy shit! this is curing me!?' The afterglow however sucked balls. Perhaps I didn't take a high enough dose. I imagine those taking ibogaine for another reason besides addiction would have a freaking awesome afterglow. I smoked cigarettes after coming out of the trip. I wish I smarter like sids, but here's the excuse, I just wasn't feeling well. I felt like I was chocked-full of estrogen and emotions were at their highest. Like I've said before, weed was the biggest aide when it came to feeling better after the trip.
 
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Also, here's my experience with low doses of ibogaine.

After several months, I got back on the opiates. Decreasing tolerance was too easy w/ low doses of ibogaine. I'm not condoning this, but I still was on an ssri when I would take a low dose and noticed no adverse effect.

I've done this several times. Some times with a single dose and some times with a daily dose for several days. I didn't have a scale, but it was a very small amount (like a small line of coke...ingested).

One small dose of ibogaine was enough to decrease my tolerances to ssri's, weed, amphetamines, and opiates.

Decreasing an opiate tolerance with ibogaine generally takes 3 daily doses along with your decreased dose of preferred opiate. Some people will require more, but with that I was able to cut my dose practically in half.

I take effexor 150mg, and one tiny dose of the ibogaine was enough to get me yawning the next day. I'm referring to the initial side effects of beginning ssri treatment. I kid you not, the very next day when I took my AD, it felt like I was starting all over again (which sucks b/c I hate the initial side effects w/ ssris).

With one tiny dose of ibogaine, you might want to hold off on amphetamine use for several days maybe more. If you do, take VERY SMALL amounts. After ingesting a small amount of ibogaine the day before, one crumb of an ir dexedrine tablet was enough to get me zoomin'.

Also, weed tolerance is noticeably decreased after one small dose the day before.

I'm not sure how all of this is possible. Perhaps noribogaine can potentiate through the coming months leading the user to believe he needs less of his preferred drug. It may be due to an alkaloid, like 18-mc, that can powerfully decrease tolerances. Or it could be a combination of both or something else altogether. I'm not sure, but it sure is a neat little plant.

The small doses won't give you insomnia or hallucinations. You'll notice a very subtle dissociative effect and your creativity will be temporarily heightened. Again no insomnia, but you will be getting up earlier. ^_^

I remember thinking in the weeks after the full ibogaine treatment, that it had turned me into an old man. As soon as I saw light, no matter how early, I had to get up. lol
 
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Wow, did Apple or Verizon send someone to convertly advertise on bluelight?

Of all places... I really hope it's just some delusional person, at the end of a psychedelic binge.
 
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