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  • BDD Moderators: Keif’ Richards

How much did it take you to OD on depressant cocktails?

C

Cartesia

Bluelighter
Joined
Mar 4, 2007
Messages
417
OK I know this is subjective.. but I'm hoping to get a general idea of how much it took you/someone you know to OD on depressants... by OD I mean stop breathing basically, or be completely unresponsive if someone tries to wake you (not even moving/groaning/eyes moving)

I was just thinking about this because you always hear about people taking too many pills but I've never known it to happen (unless it was something toxic like paracetamol rather than the depressant effect that caused the problem)...

too many opiates I can understand completely.. it's more the benzos/alcohol/etc combos that I am wondering about..

The reason I'm wondering is numerous times I've gone through tonnes of valium in a night (and usually been taking it that day at lower levels) - (with no tolerance), plus alcohol, plus opiates (as much opiates as I would normally take to be 'controllably' high - that is, not enough to be nodding/stumbling around if I took it on it's own)..

The end result is usually being a complete mess, falling all over everything and blacking out on and off, but I've never stopped breathing or become unresponsive...

So whats the story? How much did you/someone you know take to reach that point?
 
I've never blacked out or stopped breathing. It must take more than I think to OD because I remember washing down quite a bit of oxycodone and clonazepam with alcohol. I was pretty blasted, but I was OK.
 
yeahh, ive take 900mg of DPH (benadryl) with around 7 un-tested XTC pills and and enormous amount of weed and alcohol with xanax and i just blacked out on and off. but never stopped breathing.
 
I've ODed numerous times on combinations of pills: Usually, about 50-100mg of clonazepam or alpraz or, I guess, a few hundred mgs of diazepam, combined with a couple dozen random opiate pills like dilaudids (say, 48-96mg), morphine sulfate (say, 1200-2400mg), +/- oxycodone (say, 120-240mg), or, a couple times, 100mg of methadone. That was all when I was still new enough not to be able to judge my dose, or when I didn't have anything I could easily IV, so I expected too much and over-re-dosed, if I can make that word up. Once, after that, it was the crack that popped my lid. It always took the combination to turn off my lungs or make me seem dangerously unresponsive enough to other people that they called 911. Otherwise, doses that high of benzos just put me in jail or a pool of blood.
 
ive had 3-4 hour blackouts on copius amounts alcohol + ketamine where i found my self covered in blood and mud minus 1 iphone and 1 $100 coat 2 miles walk from where i last rememberd.(still had the ket in my sock tho! bonus)

but i wouldnt call that an OD, id call that a good time! haha
 
It can take quite a bit. For me it was 30-40 mgs of hydrocodone, 10ish mgs of phenazepam and 3-4 bags of decent heroin. I had a solid benzo/opiate tolerance at the time. But it can vary widely person to person.
 
Ketamine is the one drug I often black out on. I don't remember if I've blacked out from benzodiazepines but if I did, I don't remember. I have a memory box that's been blasted to shit with a baseball bat. Shattered. I can't remember the biggest moments in my life, all I remember is the times I got high. People ask me "remember when..." I'm like no, when the fuck did I do that?" My life is one big GABA blackout.
 
I have never been close to an OD..........I quit drinking altogether a long time ago so that is a big reason....

Also I have an insane opium tolerance + don't like benzos enough to take toxic doses....
 
phatass said:
180mg methadone,45mg alprazolam, 8 grams meprobamate, about 20mg of lormetazepam, aceprometazine and 20cl of 45% rhum lol... bad times
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That'll do it! Classic. Might coulda' stopped @ the alpraz & still die, if alone.

On a slightly off-topic related note, anyone know if ERs ever use benzo antagonists? I've never been given them AFAIK, maybe because the doses of benzos alone to kill you are unbelievably high, so they figure antagonizing the opioids is enough; then again, you would think when you throw muscle relaxers and alcohol in the mix, keeping the patient alive might depend on it...
??
 
socio said:
That'll do it! Classic. Might coulda' stopped @ the alpraz & still die, if alone.

On a slightly off-topic related note, anyone know if ERs ever use benzo antagonists? I've never been given them AFAIK, maybe because the doses of benzos alone to kill you are unbelievably high, so they figure antagonizing the opioids is enough; then again, you would think when you throw muscle relaxers and alcohol in the mix, keeping the patient alive might depend on it...
??
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Benzo antagonists would be a seizure just waiting to happen.

And a huge lawsuit just behind it.
 
fryingsquirrel said:
Benzo antagonists would be a seizure just waiting to happen.

And a huge lawsuit just behind it.
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Oh, yeah, right. Good point.

Still, I wonder if someone is actually starting have respiratory depression that can't be reversed any other way, and they know it's a benzo OD, will they just let you die, or maybe juice you with just a touch of flumazenil or sumthin?

I googled it, found a couple articles on using antagonists in benzo OD. Indeed, in the one I bothered to read one of the 9 patients had a seizure.
 
K'd-OUT-in-AZ said:
But wouldn't taking an amphetamine or epinephrine help get you out?
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I would guess it might help in some circumstances, though I'm not sure. I know little about human biology or what, exactly, happens when you add CNS-stims to respiratory depressants.

If so, shouldn't it/them work for opioid and alcohol ODs as well?

I know that there is research showing that if you give amphetamines to people who are under the influence of depressants (etoh, benzo, barb, etc.), they perform better on tasks like driving (the big secret!).

Epinephrine, I don't know too much about it's pharmacodynamics -- I doubt it given how short-acting it is and how narrow the gap between therapeutic and lethal dose, but I could be wrong. Pulp Fiction's fictional nonsense soured me on epinephrine-as-OD-reversal, but I know you're not just basing your knowledge on a tarentino fantasy. I would think it might get you a jolt of a pulse for a few minutes, then end. Continuous injection sounds dangerous.

Again, not my area of expertise by far -- any other thoughts on that? I'd like to know what you think.

I think that amphetamine at least would work to some degree if you're still semi-conscious. But if you're in a deep coma, would it still act to restore respiration? Will it wake you up even though it's acting on different parts of the brain? Unlike the antagonists, it's going to be affecting other systems and GABA/benzo drugs are all about slowing down all the CNS electrical impulses and function. Interesting thought.

That said, I like your idea:
I'd much rather wake up from my next OD with a shot of desoxyn than Narcan and Flumazenil.
Shoot, even epi would be better than the devil's N & F.
 
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