from oxys to opana insufflating

[skylines7]

Considering how strong Opanas are, it would be a good idea in the name of harm reduction to post a guide for the different methods of ingestion coming from Oxycodone.

After the NEW OP Formula came on the market, my area saw an influx of Opana's. I watched as many opiate tolerant people did way too much and had adverse effects, this is by assuming 40mg of Opana is just like taking 40mg of Oxycodone, which it is not.

I did some math, but it could be very wrong lol - I am a communications major not a math major. Don't attack my conclusion if it is wrong, if anything try to help find the correct conversion!

*Bioavailability and Potency are not the same thing, I'm assuming the bioavailability is the best way to make the most accurate conversions. If I am wrong, please correct me!

I came to the conclusion that 5mg of Oxymorphone is equal to roughly 20mg of Oxycodone when used intranasally. Here is the means of how I came to these numbers:

On Opanas website there is a conversion tool, for Oxycodone to Oxymorphone the conversion is .5 - so if you take 10mg of Oxycodone you are going to take 5mg of Oxymorphone, ORALLY.

The Following bioavailability's are estimates, they are meant to be in the neighborhood and I am using round numbers to make calculations easier.

Oral Bioavailability: Intranasal Bioavailability:
Oxycodone - 90% Oxycodone - 70%
Oxymorphone - 10% Oxymorphone - 40%

Using this information, 100mg of Oxycodone is equal to 50mg of Oxymorphone when taken Orally.

*To do the following conversions, I took the percentage differences - 20% for oxycodone between oral and intranasal, and multiplied that by the milligrams.
So, 100mg X .20 = 20mg. I then added 20mg to the original 100mg to get the equivalent intranasal dosing.

The effects of 100mg of Oxycodone taken orally is equal to 120mg of Oxycodone taken intranasally.

The effects of 50mg of Oxymorphone taken orally is equal to 35mg of Oxymorphone taken intranasally.

So now the equivalent does becomes 120mg of Oxycodone to 35mg of Oxymorphone when taken intranassaly.

We divide each number by 7 and we get 24mg of Oxycodone to 5mg of Oxymorphone.

I rounded 24mg to 20mg because in my subjective expeirences i felt 20mg to be more accurate of a number.

So what does everybody think about my little hypothesis lol?

 

[Poisongodmachine]

You are probably right in the ballpark although for me personally when I switched from oxycontin to opana, I was taking 60mg oxycodone at a time and BARELY getting a small warmthy buzz, I crush and split one of the 10mg opana er's and did 5mg and was hyped up and euphoric as all hell, about 2 hours later tried 15mg just to see and was nodding HARD, and thats after having a pretty high tolerance to opiates. I was taking 60mg oxycontin ( 2 of the 30's) about 3 or 4 times a day depending on when or if I went to bed. BTW sorry Im too stoned to know what paragraphs are or how to use them.

 

[Poisongodmachine]

I guess my point was you are definitely right about one thing, people need to know that 40mg of oxycodone and 40mg of oxymorphone are two totally different beasts and if you go headlong into a bottle of Opanas the first time you touch them you might be in for some adverse reactions.

 

[wahwahwah420]

Every person is different. Opanas are strong. Keep in mind a large fatty meal 30-60 minutes prior greatly increases the effects of Opana.

Happy surfing!

 

[skylines7]

I've been getting opanas for a while and I haven't tried out the large fatty meal thing yet. I've eaten a meal before, but nothing like real fatty. I'm about to get mcdonalds breakfast so we will see how it goes!

Opanas are very strong, I've had very opiate tolerant friends do them for the first time and blew chunks...they were amazed. Some people still don't know what they are, they don't know what they're missing in my opinion.

 

[ActiqAnnie]

I certainly did find that Opana was much stronger following a large meal. But even then, without alcohol (which I don't recommend because it is unpredictable and increases the amount of Opana drastically) and taken orally, Opana still has minimal bioavailability.

Going back to the original conversion: if oxycodone is less available nasally than orally, why on earth would so many people go to the trouble of snorting it? I'm not doubting you, just puzzled.

 

[Cane2theLeft]

Dosing questions should be directed to basic drug discussion.


--->BDD

 

[Morphoid]

I certainly did find that Opana was much stronger following a large meal. But even then, without alcohol (which I don't recommend because it is unpredictable and increases the amount of Opana drastically) and taken orally, Opana still has minimal bioavailability.

Going back to the original conversion: if oxycodone is less available nasally than orally, why on earth would so many people go to the trouble of snorting it? I'm not doubting you, just puzzled.

Most snort oxycodone because of the almost immediate onset. I think some (not me) feel that the fast onset is a fair tradeoff for the lower bioavailability.

Personally, I only ever eat or plug. Plugging gets the best of both worlds, fast onset and high BA. Sadly it's not quite as socially acceptable, especially in public or with friends.

 

[tunafingers]

I certainly did find that Opana was much stronger following a large meal. But even then, without alcohol (which I don't recommend because it is unpredictable and increases the amount of Opana drastically) and taken orally, Opana still has minimal bioavailability.

Going back to the original conversion: if oxycodone is less available nasally than orally, why on earth would so many people go to the trouble of snorting it? I'm not doubting you, just puzzled.

IME the effects are stronger orally, but insufflation offers instant gratification. Plus some people just have a nasal fixation and/or ulcers from their prolific usage of oral drugs.

 

[ActiqAnnie]

Plugging gets the best of both worlds, fast onset and high BA. Sadly it's not quite as socially acceptable, especially in public or with friends.

Now, now...maybe you're underestimating your friends? Society has come a long way towards acceptance. Have you ever even tried taking a plug during Thanksgiving dinner?

I'm sure all you need to do is explain while you're doing it about the greater bioavailability...

Let us know how it goes!

 

[DavisK4high247]

IME the effects are stronger orally, but insufflation offers instant gratification. Plus some people just have a nasal fixation and/or ulcers from their prolific usage of oral drugs.

Opana(oxymorphone) is not as stong orally as other ways of duing it. Oxymorphone has an oral bioavailbilty of around 10% like morphine oraly is 10% , but snorted morphine is 30-40% more absorbed into the bloodstream and oxymorphone is 40-60% snorted ,while both are 100% IV of course.
Oxycodone unlike morphine and oxymorphone ,is highly effective orally, like 90% maybe eating oxycodone,versus 50-60% maybe by snorting it. This means you can get higher eating oxycodone than snorting it, but you only get 10% orally of oxymorphone and morphine as well.Getting 40-60% or something ,maybe higher snorting oxymorphone makes sense compared to orally taking it. And oxymorphone is much more potent than oxycodone and morphine nasaly,and especially IV, so if you inject oxymorphone be careful..

 

[Morphoid]

Now, now...maybe you're underestimating your friends? Society has come a long way towards acceptance. Have you ever even tried taking a plug during Thanksgiving dinner?

I'm sure all you need to do is explain while you're doing it about the greater bioavailability...

Let us know how it goes!

I laughed! Sadly the first time I ever plugged was during a friend's bar mitzvah. Needless to say I only ever did it privately after that.

 

[Kudders]

I usually drop 15-20mg chute then snoot 5-10mg when I feel the effects. Even though I get a terribly stuffy nose and peeps who know me know I'm partying, but I prefer the nasal route for onset. I wana try opana dagnabit

 

[K'd-OUT-in-AZ]

Opana(oxymorphone) is not as stong orally as other ways of duing it. Oxymorphone has an oral bioavailbilty of around 10% like morphine oraly is 10% , but snorted morphine is 30-40% more absorbed into the bloodstream and oxymorphone is 40-60% snorted ,while both are 100% IV of course.
Oxycodone unlike morphine and oxymorphone ,is highly effective orally, like 90% maybe eating oxycodone,versus 50-60% maybe by snorting it. This means you can get higher eating oxycodone than snorting it, but you only get 10% orally of oxymorphone and morphine as well.Getting 40-60% or something ,maybe higher snorting oxymorphone makes sense compared to orally taking it. And oxymorphone is much more potent than oxycodone and morphine nasaly,and especially IV, so if you inject oxymorphone be careful..

Wrong buddy.

Morphine has a 25-32% oral/rectal bioavailabiliy. Insuffulated- 15-20%. Chitosan (a linear polysaccharide that helps absorb drugs better) has been shown to increase nasal bioavailability of morphine from around 10-20% to over 60%, SC-60%, protein binding 30-40%

Oxycodone has an oral bioavailability of 60-87% and intranasal widely varies from 45-70%

Oxymorphone has a nasal bioavailabilty of 43%. Oral as low as 10-20%

 

[OhSeeAT]

What is the highest bioavailability for oxymorphone besides for IV, because they are a bitch to prep?

In my experiences, 40 MG OF OXYMORPHONE = 70-80 MG OF OXYCODONE, so 20mg of opana is closer to 40 mgs of oxycodone.

For highest effective potency of oxymorphone would it be correct to eat a mild dose of benadryl, eat a fatty meal and wash it down with a big glass of grape fruit juice?? Where are my opiate whizzs'?

 

[verso]

The grape fruit juice, unless I'm mistaken, will not have too much of an effect on oxymorphone. The reason why others sometimes take oxycodone with grapefruit juice is because the grapefruit juice will help to metabolize the oxycodone into oxymorphone more effectively. Because you're already taking the oxymorphone to begin with, I'm not sure what it would do. It could lengthen the duration of the high, maybe? But I don't think so.

I would try eating a fatty meal, but not fat from dairy. I read somewhere that fat from dairy isn't the best fat to take in when you're trying to potentiate an opiate. (This could be entirely, ridiculously false. But I do remember reading it somewhere.) To be safe, I would try peanut butter or something like that.