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The Big & Dandy Methoxetamine(2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) Thread

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I would agree a lot with Benson and Knockando. It was hard to find suitable music or settle but when I did it felt great.

I watched Koyaanisqatsi (which I would recommend for dissociative viewing) and got quite into the music at times.

What really hit the spot though was Fuck Buttons. It's a bit droney, but euphoric too, great to bliss out to!

I don't have any Orb on my mp3 player but I can imagine they could work quite well too.
 
If anyone still wonders if MXE and alcohol, both in high doses, is a bad idea or not: My friend decided to take 40mg of MXE after 2 beers and a few shots. Needless to say, he was not a happy camper in the club after vomiting and being thrown outside. So don't do it.

However, after allowing my tolerance to ketamine go down a bit I decided to try a 40mg IM dose after a particularly shitty day. I must say, this compound is beautiful. After turning off all the lights, I was on grooveshark and found that I was in the mood for some classical music. Each new composition was a brilliant new story unfolding in my closed eyes. It was absolutely wonderful, and I found that the music was perfect for MXE. In each piece there was a story that was unfolding, and MXE adapted to each creating a wonderful display that intertwined beautifully. I highly suggest a nice composition for someones next trip, if you like that sort of stuff.
 
benson7 said:
I've tried MXE once, when I combined 40mg with 50mg AMT. The results were mixed and the trip improved as the MXE wore off. I had numb lips and hands and experienced dreamy lost thoughts where I would forget where I was. Walking felt very strange. It was not a comfortable experience and I felt no opiate like high, maybe the AMT masked it somewhat in this respect. There was a level of confusion which really put me down. Music didn't seem enjoyable whilst the MXE was felt, although oddly when a CD would finish I would feel a little empty and awkward as to what to do next.

I might try a dose again on Sunday on its own if I fail to acquire any other substances over the next few days.

To summarise, MXE and AMT is not a good combo and MXE is definitely not a clubbing drug.
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I want to bring up a potential point of caution. This link is an old trip report on Lycaeum about the synergistic / unexpected effects with DXM + aMT. It covers a lot of neuropharmacology I am unfamiliar with but I believe the nuts and bolts of the DXM side of the reaction is dictated simply by the fact it is an NMDA antagonist. MXE is also obviously an NMDA antagonist. Can someone with knowledge in this area touch on whether or not a similar phenomena would happen with MXE + aMT? This could potentially explain some of the negative effects benson experienced.
 
^ I think the problem with DXM + aMT is that DXM plays with serotonin whilst aMT is a mild MAOI - very dodgy combo. Ketamine doesn't affect serotonin and this stuff almost certainly doesn't either. Doesn't feel like it does, for sure. Not a chemist though.

On the booze thing, I had no problem combining with alcohol but I am also odd cos I mix ket and booze regularly with no issue. Most find it a queasy combo with ket and I suspect this would be much the same.
 
@Shambles. Thank you for your thoughts, I had overlooked the possibility of negative effects caused by serotonin syndrome.

I would still appreciate other theories / clarifications if anybody can help. Shambles is very likely correct in that MXE + aMT pose no particular danger but the author of that trip report said the following -- "Combine a 5HT agonist (aka AMT for example) with an NMDA-blocker (aka DXM for want of something cleaner like ketamine)". His chemistry is a bit razzle dazzle for me to know if he has a clue what he's talking about, but he does seem to think ketamine would have a similar effect. But he also says something so simple as a 5HT agonist, which is most commonly used psychedelics. I have certainly mixed an NMDA antagonist with a 5HT agonist before. So is there actually any synergistic effects happening in that TR and it is just between aMT and DXM? Or perhaps due to interaction between aMT and NMDA antagonists?
 
Shambles said:
^ I think the problem with DXM + aMT is that DXM plays with serotonin whilst aMT is a mild MAOI - very dodgy combo. Ketamine doesn't affect serotonin and this stuff almost certainly doesn't either. Doesn't feel like it does, for sure. Not a chemist though.
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I think the reason you shouldn't combine them has more to do with the fact that aMT is a serotonin releaser and DXM is a serotonin reuptake inhibitor. The combo results in a flood of serotonin in the synapse because the serotonin is being released while at the same time it's being prevented from being mopped up by the reuptake inhibition of the DXM. The same caution holds for DXM and any other serotonin releasers, e.g. MDMA, 4-FA, meth, MDAI, etc.
 
MXE + DXM = Bad.
I nearly killed my partner with this combo. I spent 48 hrs with slurred speech and bad balance, she could hardly stand and went into a near comatose state. Luckily she slept through most of it, but managed a couple of concussions trying to go to the bathroom.

We've both tried MXE on it's own several times (up to 100mg) and love the stuff, but I am very wary about mixing it with anything but weed from now on.

Though NYE we are attempting our last 6-APB tablet each followed by 50mg MXE each after the come up; anyone have any experience of this?


P.S. I'd like to introduce a psychedelic towards the end of the MXE, I have AMT and 5-MEO-DALT, my partners only experience with psychedelics is a single acid tab over 10 yrs ago, though I'm fully experienced with most psychedelics (them being my favorite category), any suggestions as to which is going to be best with the APB + MXE combo?
 
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Psiclo said:
MXE + DXM = Bad.
I nearly killed my partner with this combo. I spent 48 hrs with slurred speech and bad balance, she could hardly stand and went into a near comatose state. Luckily she slept through most of it, but managed a couple of concussions trying to go to the bathroom.

We've both tried MXE on it's own several times (up to 100mg) and love the stuff, but I am very wary about mixing it with anything but weed from now on.

Though NYE we are attempting our last 6-APB tablet each followed by 50mg MXE each after the come up; anyone have any experience of this?


P.S. I'd like to introduce a psychedelic towards the end of the MXE, I have AMT and 5-MEO-DALT, my partners only experience with psychedelics is a single acid tab over 10 yrs ago, though I'm fully experienced with most psychedelics (them being my favorite category), any suggestions as to which is going to be best with the APB + MXE combo?
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Mixing psychedelics with MXE would be very heavy going indeed. I mean, in my deepest holes, I honestly thought I had permanently fucked up reality for the whole world and had gone stark raving mad. If you take a psychedelic, just be prepared for an even more extreme level of mind-fuckery and mania.
 
psood0nym said:
I think the reason you shouldn't combine them has more to do with the fact that aMT is a serotonin releaser and DXM is a serotonin reuptake inhibitor. The combo results in a flood of serotonin in the synapse because the serotonin is being released while at the same time it's being prevented from being mopped up by the reuptake inhibition of the DXM. The same caution holds for DXM and any other serotonin releasers, e.g. MDMA, 4-FA, meth, MDAI, etc.
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Thanks for the clarification. Psood0 :)

I think that's what I was trying to say in a roundabout way but - as mentioned - I certainly am no chemist :D

Dumbstruck: Despite my lack of chemistry skillz, I am pretty much certain it's an issue specific to DXM that doesn't affect other NDMA-botherers like ketamine. I would never combine DXM with and serotinin-seducers but combo them with ket all the time. Have never heard of it being an issue with any other than DXM.

PS: As for mixing with psyches, it was gobsmackingly good with 2C-B and DMT. Will hopefully be mixing with 2C-D (and probably both 2C-B and 2C-D together) next time I get some. Maybe try it with acid too if I get enough to cover it all. Have also mixed it with other dissociatives (ketamine and 3-MeO-PCE - ketamine throughout and added 3-MeO-PCE to the mix a few hours into the session) with great success. Could definitely see it going well with 6-APB but don't know if there is potential for dodgy interactions with that one.
 
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First off hello to all the bluelighters.
I've been reading the reports on aMT+MXE and I thought i would add my expierience of these two chems.
I've tried this combo 3 times now and although it's 'one crazy ride' i've enjoyed the trip very much. Hav'nt been to place like that since the days of doing 3 black microdots, although i only comparing to lsd because of the visuals and confusion that can be felt with this. It is a totaly diferent animal IMO, much nicer cleaner feeling.
First test was 35mg aMT in a shot of southern comfort(seemed to dissolve ok) left a few flakes after stiring (might just have been impurity left).waited till it seemed it had platued, 2 hours approx, then administered 35mg MXE sub-lingual, with another 35mg an hour later. Great night on my own listening to music and watched a film 'the expendables' which had me in stiches all the way though, watching stallone in a cartoon like performance v funny, not seen film before and not a clue what was going on in it.
Second time was with a friend who wanted to try it so there was going to be 2 of us so upped the dose a bit and went for stacking the peaks (lol what was i thinking) 45mg aMT followed by 40mg MXE an hour later and 40mg MXE an hour after that............OMG this was so much stronger than first test how do i describe this one........alice through the looking glass wraped in marsh mellow stuck in the matrix.
Glad a friend was with me, manage to stay in good place most of the time and got pulled out when things got tooo wiered. Friend was displaying some split personalities, 1 minute bernard manning, then noel coward and then ray winston (lol scarey) but he seemed to calm down when introduce to the xmas tree (1 of those fiber optic things) which seemed be be alive.
Third test was smaller 20mg aMT, 20mg MXE 1 hour later
This was still a nice place more like an evening getting fairly smashed but leaveing you in full control and with a total grip on the situation.Still good visuals and was able to follow a film this time.
Will post some more if i find anything worth adding.
Hope this helps people decide whats best for them and stops someone going too overboard on their first go.......happy days....%)
 
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Yesterday I finaly got to try some MXE, and to be honest I wasn´t that impressed. At times I was bored, other times just annoyed with the effects.

I started out by taking 28 mg sublingual. After 1 hour I got impatient, and because I thought I really didn´t felt anything, I snorted an additional 16 milligrams. After that, things started getting weird quickly.

I tried to watch the Chinese movie “Fallen Angels” by Wong Kar Wai, it proved to be a bad choice. Even when I´m sober I am having an extremely hard time understanding the plot in his movies. Still I was sucked into it´s bleak and cold atmosphere. Didn´t like it actually…..

I tried to watch some other movies, but that failed aswell.
In the end I watched Star wars, episode 1: the phantom menace, and I just thought the effects were really bad. Completely cheesy.
It was like I could see the crummy latex masks, the people who were dressed up like aliens, were wearing. And I could totally see that Yoda was just a puppet.
Also picture quality seemed worse when on MXE. Much more pixelated.

Coming down, I went for a long walk, it was 3:30 AM, and the streets were completely empty. It was pretty cool actually. Best part of the trip. We got lots of snow here, so that was nice.

It´s not that I wouldn´t repeat taking MXE again, but I think I would like to either mix it with a psychedelic (4-aco-dmt maybe) or I would double the dose, in the hope of getting a more immersive experience. I must say that all in all it was a lot less psychedelic than I expected.

I want to add that I am not really that experienced with dissociatives. I take a little ket now and then, but never really “hole” with it. And I tried DXM once, but that´s a long time ago now.
 
Fagott said:
Yesterday I finaly got to try some MXE, and to be honest I wasn´t that impressed. At times I was bored, other times just annoyed with the effects.

I started out by taking 28 mg sublingual. After 1 hour I got impatient, and because I thought I really didn´t felt anything, I snorted an additional 16 milligrams. After that, things started getting weird quickly.

I tried to watch the Chinese movie “Fallen Angels” by Wong Kar Wai, it proved to be a bad choice. Even when I´m sober I am having an extremely hard time understanding the plot in his movies. Still I was sucked into it´s bleak and cold atmosphere. Didn´t like it actually…..

I tried to watch some other movies, but that failed aswell.
In the end I watched Star wars, episode 1: the phantom menace, and I just thought the effects were really bad. Completely cheesy.
It was like I could see the crummy latex masks, the people who were dressed up like aliens, were wearing. And I could totally see that Yoda was just a puppet.
Also picture quality seemed worse when on MXE. Much more pixelated.

Coming down, I went for a long walk, it was 3:30 AM, and the streets were completely empty. It was pretty cool actually. Best part of the trip. We got lots of snow here, so that was nice.

It´s not that I wouldn´t repeat taking MXE again, but I think I would like to either mix it with a psychedelic (4-aco-dmt maybe) or I would double the dose, in the hope of getting a more immersive experience. I must say that all in all it was a lot less psychedelic than I expected.

I want to add that I am not really that experienced with dissociatives. I take a little ket now and then, but never really “hole” with it. And I tried DXM once, but that´s a long time ago now.
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actually Yoda was CGI
 
Combining MXE with Star Wars: Episode I seems to be a dangerous combo. Causes grumpiness and appalling image quality.
 
I've had Methoxetamie 3 times with alcohol, at doses of ~50mg, 75mg, and 100mg and never had ill effects. None of these times I would say I was 'drunk', probably somewhere around 8 units had been consumed.

I've also had ~40mg of Methoxeticyclidine once while quite drunk. Probably more like 20 units, consumed over a period of about 8 hours though, with the 3-Meo-PCE taken at the end of those 8 hours, and no further alcohol consumed.

None of these occassions have resulted in any ill effects whatsoever.
 
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