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Propylhexedrine - A new side of the drug

Pseudovoyager

Bluelighter
Joined
Oct 14, 2010
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Southeast US
This is an old experience report that was posted by me at another forum. I am editing out the use of SWIM and posting it here for further input. Hopefully someone here can throw some constructive ideas at me on this :)
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First a little background: I rarely, if ever, have had any true sober hallucinations or episodes. Just some mania here and there, and sleep deprivation. I use a decent bit of substances (at least 3 to 4 times a week, I'd say.) This story is going to include 5 substances used at separate times but within close intervals. I'm aware that the combinations herein were probably stupid and dangerous. Silly me. I in no way recommend that anyone try anything my wife and I did in this story.

I had an experience the other night like no other. It was full of intensely real hallucinations. But the catch was the lack of delirium and the presence of total insight. Please, anyone, if you can, tell me how I reached this state or what kind of brain chemistry could've allowed this to happen. Story Follows:

Thursday afternoon I recieved 60 1mg kpins. Happy about this, no doubt, I popped one and headed to the grocery store with my wife. We returned home and had some dinner, and took a couple of benzos apiece. Mind you, we usually have enough sense to know better than to not hide our stash after a couple of benzos. Momentary lapse of reason. Long story short (mainly because he has no idea of what happened in that span of time), I came to on Friday afternoon with 20 Kpins left. Well shit.

Still felt the aftermong of the kpins well into Sunday and some into Monday. Tuesday night it happened. Hopefully some of you are familiar with Propylhexedrine, or Benzedrex. Extracting the contents of these little inhalers will fuck one up right and proper, close in feeling to a good bit of some strange crossbreed of amphetamine and MDMA; sort of like a weak dose of meth. Anyway, my wife and I decided to get some and have a speedy night together. We each consumed the extract of two inhalers, or 500mg apiece. This was the 4th or 5th time we'd done this in the span of about 2 months so we had a general idea of what to expect. Well, baby, we were in for a ride.

About an hour and a half into our fun-filled night, I noticed something felt...different...about the Propyl. My heartrate was not nearly as fast or hard as usual, however, that may have been due to some benzo still lingering in our systems. As the night progressed, about T+2:30, I noticed I wasn't really speeding that much anymore, so I downed a Bawls (high-caffeine carbonated beverage), and my wife had a Starbucks frapuccino thingy. Half an hour after, we each had 50mg caffeine HCl in the form of Vivarin tablets. That kept us going for a while, but eventually, around T+3:45 or 4:00, I noticed I was not speeding very much once again; strange. The duration seemed a lot shorter than usual, and our dose was a higher one than we normally took. Then I noted a difference: my mood was SUPERB and hyper-emotional. Normal for propyl, but my mood was not the expected speedy euphoria. It was a calm, yet burstingly intense, love for everything. My speed had turned into boundless controllable energy.

This is where it all changed. I was getting hot and decided to go grab the fan from the living room. It was dark when I went in the room. That's when I noticed a little box in the corner. Strange, I hadn't noticed that before. I went to grab it and suddenly it disappeared into thin air!

A pause. In my younger teen years, I abused a good bit of diphenhydramine for some stupid reason. If any of you are familiar with the kind of visual hallucinations you get (NOT the delirium or the trance states; the actual active hallucinations; cobwebs, sparks, etc.), you will know what I mean. Continued:

When the box disappeared, I realized it had looked exactly like a benadryl hallucination. Oh shit. What was that all about? I walked around a bit more and quickly realized I was beginning to see things. Amorphous, gelatinous-looking blobs or translucent large bubble-like walls began to appear every now and then on objects. The walls started to breathe. I called my wife into the living room, getting a little scared that I was about to start some kind of retarded deliriant trip. I asked her to "pick up the box in the corner." To my surprise, she tried. A 'what the fuck' escaped her lips.

Something was different. These hallucinations were not sinister. They interacted with us. For hours, they played with balls of energy, sat in a pitch-black room and flew through spider-web like purple neon portals, which later became a comfortable cottage room with a cozy fireplace. We went on a nature walk and watched the stars fall out of the sky, and the plants grow new shoots at awesome speeds. We had a spiritual experience. And the striking difference was....the pure insight. The total lack of delirium. The "NOW"ness of the experience and the extremely vivid and tangible nature of the hallucinations.

Finally tired, we went to bed. My wife wasn't hallucinating anymore. But mine had only gotten more intense. I laid in bed and watched as silver streaks flew out of my peripheral vision from unspecified directions, turning slowly into neon bright colors as they thickened and become exotic and breathtaking flowers and vines. I could even pick them up and move them around. They were friendly to me. I was completely conscious that I was hallucinating, laying there, waving my hands around, playing with the flowers and watching vines creep up my arms....at one point a friendly snake coiled around my wrist before I fell asleep.

This was the most intense hallucinogenic experience I have ever had for a few reasons that I yearn to understand with an almost scary obsession. Why did my wife and I both have the same experience with shared hallucinations on this occasion? What magical combination was it that we did? Why were the hallucinations so vivid, so clear, so interactive, friendly? Why the insight?

I know how anticholinergic hallucinations feel. This couldn't have been any further from that, yet the intensity of this experience was of comparison.
I have read up on Peduncular Hallucinosis, and this sounded the most similar, but neither of us have brain lesions that we know of.

The ONLY even plausible explanation I can surmise is, hey, look at that, amphetamine/stimulant psychosis. But it was not unpleasant like it s. There was no sleep deprivation. There was no mental confusion. There was peace rather than paranoia.

Please, if anyone has ever experienced anything like this...or knows by what routes in the brain something like this would be caused...post!!
The level of obsession I have with figuring out just what happened is starting to freak me out. I *Need* to understand it. It was so breathtaking. I want to repeat it, any way possible. And again I ask...why would my wife and I both experience this at the same time, both having never had an experience even close in nature before?

I digress. :o
 
Sounds like some kind of stimulant psychosis of sorts which I'm sure the benzos had some kind of role in. That benzedrex stuff scares me. I made tea with just one cotton, so ~250mg, and for about two hours I felt really damn good, and then felt like I was birthing a predator in my stomach for another hour or so. I was holding my phone at one point with 911 dialed in, waiting to press send....it was that bad. I didn't get any hallucinations but there's just something about that stuff that screams TOXIC!!!!!! :(

It's unfortunate too because honestly for those first two hours I felt fan-freakin-tastic, just as you said, a moderate MDMA feeling of sorts.
 
After trying out some other legal stimulants recently (mephedrone, methylone), I'm realizing that propyl is the closest to methamphetamine in its effects, which can't be good. A tiny dose keeps me awake for HOURS, I obsessively pick at my skin and get "stuck" on pointless, repetitive tasks and clench my jaw until it pops and clicks like crazy. Can you say "tweaker"?

Mephedrone is like cocaine in that it makes you want to snort, re-snort and re-re-snort every few hours; methylone is almost identical to MDMA (but shorter) and propyl is like everything I've ever read about meth.

Been using low-dose (an inhaler every 8-10 days) propyl for a little over a year now and find it very hard to quit. I've seen reports of people using it for over THIRTY years, and one Oklahoma guy who injected it for 20-some years before dying an untimely death, so it's definitely got addictive potential for peeps who like stims but can't get them. Very close to meth in its molecular structure as well.

I strongly advise against taking an entire inhaler at once, eating the cotton or using it too frequently. As with any drug, there are ways to reduce the risks of harm, but that doesn't make it completely safe. I just wish more was known about its dangers in comparison with amphetamines and other stims.

Great report, btw. Hope things work out for ya!
 
Yeah, propylhexedrine is pretty wild for a widely available OTC chemical.

Out of all the store-bought legal highs there are, it is by and far the most recreational. It's highly euphoric, and very sexually stimulating. I have never taken more than half an inhaler in one dose, though, and usually take the second half maybe three or four hours in. I keep seeing reports like this of people taking four times the doses I've been taking, and I couldn't imagine doing that!
 
I've read that it's pretty neuro toxic and that scares me away. It certainly does feel neuro toxic, because it works so well for something OTC!! I've thought a few times about how it would be cool to extract the propyl and get it into capsules and pop them during a night out. That would certainly be incredible for something OTC, however that stomach ache I got, plus what I read about neuro toxicity scares me off completely.

Things this good always come with some kind of price.
 
It`s probably not terribly neurotoxic, certainly nowhere near MDMA or methamphetamine. It`s a straight up dopamine / norepinephrine releasing agent with some additional adrenergic effects (correct me if I`m wrong). There seems to be little to no serotonergic effects. The MDMA-like quality to this drug might simply be some emergent property from a combination of neurotransmitter release and adrenal effects.

Where did you read about the neurotoxicity? Can you cite a source? I`m simply curious. If anything, I would think it`s mildly cardiotoxic, but I would place the neurotoxicity somewhere around Adderall, i.e., not significantly. Plus, most people don`t binge on this stuff like amphetamines. Anyway, this is mostly my opinion / hunch, but I would like to see a study if you have access to it.
 
It`s probably not terribly neurotoxic, certainly nowhere near MDMA or methamphetamine. It`s a straight up dopamine / norepinephrine releasing agent with some additional adrenergic effects (correct me if I`m wrong). There seems to be little to no serotonergic effects. The MDMA-like quality to this drug might simply be some emergent property from a combination of neurotransmitter release and adrenal effects.

Where did you read about the neurotoxicity? Can you cite a source? I`m simply curious. If anything, I would think it`s mildly cardiotoxic, but I would place the neurotoxicity somewhere around Adderall, i.e., not significantly. Plus, most people don`t binge on this stuff like amphetamines. Anyway, this is mostly my opinion / hunch, but I would like to see a study if you have access to it.

It's crazy how hard it is to find (scientific, reliable) information on how propylhexedrine affects the brain. The drug has been in use since 1949 yet I have never seen it's human binding affinities (and I have searched). Using Google Scholar and Google Books, there are a couple of references that it is "likely similar to amphetamine," and it's included in a 1964 study on noradrenaline re-uptake inhibition in the rat heart. All that can be gleaned from that study is that propylhexedrine has 130% relative affinity for noradrenaline re-uptake inhibition compared to phenylethylamine in the rat heart.
 
Unfortunately the best source I have for propylhexadrine neuro toxicity is a Google search for "propylhexadrine neuro toxicity". :p

As stated above, not much information is out there but I read in a couple places that it's "probably neuro toxic". That's about as good as it gets. I suppose with similar preventative-maintenance to MDMA, as in load up on vitamin C, drink water, don't binge, and don't mix, I can't see it being the end of the world if I use it once in a blue moon.

Maybe this is a good opportunity to share some collected information on neuro toxicity? Perhaps it's not as bad as we think? Perhaps worse? If it really is similar to adderall in side effects, then shit, why the hell not?
 
I tried Benzendrex last week. I ate one inhaler (I was told to consume only the dark part of the inhaler, so I only ate about 1/3 of the total size of it) and felt 'aight for a few hours. Then I felt horrible, horrible, horrible for 36 hours. It was worse than any meth or coke comedown I have ever had. I got a fever, full flu symtoms, vomited my ass off, and felt horribly depressed on top of it.

Benzedrex is one of only a few drugs that I have tried that I will NEVER try again. I wouldn't eat one even if someone offered me $100 to do it. Its clearly very toxic to the body.
 
I tried Benzendrex last week. I ate one inhaler (I was told to consume only the dark part of the inhaler, so I only ate about 1/3 of the total size of it) and felt 'aight for a few hours. Then I felt horrible, horrible, horrible for 36 hours. It was worse than any meth or coke comedown I have ever had. I got a fever, full flu symtoms, vomited my ass off, and felt horribly depressed on top of it.

Benzedrex is one of only a few drugs that I have tried that I will NEVER try again. I wouldn't eat one even if someone offered me $100 to do it. Its clearly very toxic to the body.

This.
 
I tried Benzendrex last week. I ate one inhaler (I was told to consume only the dark part of the inhaler, so I only ate about 1/3 of the total size of it) and felt 'aight for a few hours. Then I felt horrible, horrible, horrible for 36 hours. It was worse than any meth or coke comedown I have ever had. I got a fever, full flu symtoms, vomited my ass off, and felt horribly depressed on top of it.

Benzedrex is one of only a few drugs that I have tried that I will NEVER try again. I wouldn't eat one even if someone offered me $100 to do it. Its clearly very toxic to the body.

I see this a lot, but I am seriously baffled. My wife and I have partaken of Benzedrex probably 30 or 40 times over the past 2 years. Never within one week of each other, always extracted into an acid like lemon juice or lime, and never eating the actual cotton, without *any* comedown whatsoever like mentioned. Never sick, never over-stimulated. Are the people who have experiences like yours doing something differently? We have only taken more than one inhaler apiece maybe twice, nad that *did* have some slight adrenergic side-effects, but otherwise...nothing but enjoyment. It's worth noting, though, neither of us had any stimulant tolerance whatsoever at that time. We don't really do Propyl anymore, as we "had our time" with it, I suppose.

Never felt Neurotoxic to either of us, really. Perhaps it had something to do with the fact we were both in very active lifestyles and took vitamin and mineral supplements nearly daily.
 
I see this a lot, but I am seriously baffled. My wife and I have partaken of Benzedrex probably 30 or 40 times over the past 2 years. Never within one week of each other, always extracted into an acid like lemon juice or lime, and never eating the actual cotton, without *any* comedown whatsoever like mentioned. Never sick, never over-stimulated. Are the people who have experiences like yours doing something differently? We have only taken more than one inhaler apiece maybe twice, nad that *did* have some slight adrenergic side-effects, but otherwise...nothing but enjoyment. It's worth noting, though, neither of us had any stimulant tolerance whatsoever at that time. We don't really do Propyl anymore, as we "had our time" with it, I suppose.

Never felt Neurotoxic to either of us, really. Perhaps it had something to do with the fact we were both in very active lifestyles and took vitamin and mineral supplements nearly daily.

Perhaps. I soaked my cotton in grapefruit juice and drank that, I didn't eat the cotton. I'm not VERY active, but I'm definitely not a couch potato, and I also take vitamins daily. There's a slight chance there was a bad reaction with my medication, unlikely, but all I remember was writhing around on the floor wailing, holding my head and stomach, debating if I should call 911. Very scary experience for me!! :(

So, from such usage, you don't feel any lingering effects like fatigue? No kind of anhedonia? The neuro toxicty is what scares me the most. The stomach ache/head ache I got could've easily been me just taking more stimulant than I was prepared for, I have a super low tolerance to amphetamines. I have experience with MDMA, MDA, drone, etc., and I never had any kind of experience even close to this.

Honestly I'll probably just steer clear of it until there's hard evidence that it's not damaging...
 
What medication were you taking at the time? No, no anhedonia or anything. In fact, I believe Propylhexedrine to be slightly more serotenergic than people give it credit for; it was actually therapeutic for my wife's relationship and I, akin to small doses of MDMA.
 
I see this a lot, but I am seriously baffled. My wife and I have partaken of Benzedrex probably 30 or 40 times over the past 2 years. Never within one week of each other, always extracted into an acid like lemon juice or lime, and never eating the actual cotton, without *any* comedown whatsoever like mentioned. Never sick, never over-stimulated. Are the people who have experiences like yours doing something differently? We have only taken more than one inhaler apiece maybe twice, nad that *did* have some slight adrenergic side-effects, but otherwise...nothing but enjoyment. It's worth noting, though, neither of us had any stimulant tolerance whatsoever at that time. We don't really do Propyl anymore, as we "had our time" with it, I suppose.

Never felt Neurotoxic to either of us, really. Perhaps it had something to do with the fact we were both in very active lifestyles and took vitamin and mineral supplements nearly daily.


I am not a big fan of stimulants in general, so that probably plays a large part. I like doing coke, mdma and mephedrone, but wouldn't say I get an amazing euphoria off of any of them. Just a mood lift and a loose mouth.

I think the menthol and the other additives play a large part in the toxicity on benzedrex. But whatever it was, I'd suggest anyone who is not a big fan of stimulants to steer clear of it. I am young, very healthy, excercise daily, and this stuff made me feel like I was being trampled upon by elephants that were on fire.
 
I think the menthol and the other additives play a large part in the toxicity on benzedrex

Yes, I agree. Large doses of Menthol oil can be harmful, and if large enough, fatal. I wonder how Lavender oil affects the quality of the experience.

It would be interesting to perform an A/B extraction on benzedrex and see how different it feels being pure Propylhexedrine. Perhaps one day I'll actually do it.
 
I'm on 200 lamotrigine daily but I've taken MDMA, MDA and mephedrone without issue. I might try it again with just half a cotton's worth. Still sketch on it...
 
I took Lamotrigine for a short while about 4 years ago. Seriously screwed with my head. Weird drug, I'd be concerned with the safety of combining it with just about anything. Be careful!
 
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