Sublingual vs. Rectal vs. Oral potency of psychedelics?

[thelearner]

Read in the Big & Dandy 2C-D thread that rectal admin is roughly 2.5x more potent than oral admin.

In general, I tend to trip in social settings and while out at a rave, bar, club, etc. plugging is an impractical option. I'm sure I could manage it with some lube, but I can't exactly bring the ol' bottle of KY along as it'd be rather burdensome in my pockets, not to mention an epic disaster if it exploded all over my pants whilst tripping.

Anyway, I digress...

I've lately taken to creating a capsule combining the active substance with crushed Altoid mints (for taste), opening the capsule, and taking it sublingually for increased potency. Can anyone shed some light on how potency sublingually would relate to oral / rectal potency?

I know that theoretically, since the drug is entering directly through a mucous membrane it should be identical, but saliva production and consequent swallowing before complete absorption seems like it would cause sublingual administration to be somewhat less potent than rectal.

Any guesses or data? My best guess:

Oral: 1x
Rectal: 2.5x
Sublingual: 1.75x

 

[caseface99]

Since you shouldn't be abusing psychedelics anyway, does it really matter? I could see this in OD for heroin or something, but really? here?


Either way are we talking about 2c-d or psychedelics in general? Because every drug is different, and your title said psychs. But your post says 2cd, just you basically answered your own question..

 

[mr.mackey]

Since you shouldn't be abusing psychedelics anyway, does it really matter? I could see this in OD for heroin or something, but really? here?

Hey man different strokes for different folks, if he wants to trip in a bar or rave he has every right to.

I have heard mixed results about administering drugs sublingually, some people report an increase in potency, but qualitatively different effects (theres a report on erowid about how sublingual seemed to reduce the negative effects of 2C-E, but also reduced some of the psychedelia). the rectal route is definitely more potent, and for myself, and I think for most people it is about 1.5-2 times stronger
than orally.

I think one could find out by systematically keeping track of dosage, duration and intensity in the same environment, conduct trials to determine how it effects you before doing it in places you are not as familiar with

 

[thelearner]

Since you shouldn't be abusing psychedelics anyway, does it really matter? I could see this in OD for heroin or something, but really? here?


Either way are we talking about 2c-d or psychedelics in general? Because every drug is different, and your title said psychs. But your post says 2cd, just you basically answered your own question..

Who said I was abusing them? I didn't say I used them every time I go out, and I didn't say I used them frequently. I'm simply trying to open up a discussion about the change in potency based on routes of administration, and identifying that it's impractical for me to plug in the environments in which I generally trip.

But hey, thanks for being a jerk and making assumptions instead of being helpful!

In any case, I'm talking about psychedelics in general, not just 2C-X compounds.

 

[thelearner]

Hey man different strokes for different folks, if he wants to trip in a bar or rave he has every right to.

I have heard mixed results about administering drugs sublingually, some people report an increase in potency, but qualitatively different effects (theres a report on erowid about how sublingual seemed to reduce the negative effects of 2C-E, but also reduced some of the psychedelia). the rectal route is definitely more potent, and for myself, and I think for most people it is about 1.5-2 times stronger
than orally.

I think one could find out by systematically keeping track of dosage, duration and intensity in the same environment, conduct trials to determine how it effects you before doing it in places you are not as familiar with

Excellent point. I wonder if perhaps we could also identify not only change in potency depending on ROA but also change in effects. It would seem that first pass metabolism would probably create different metabolites depending on the chemical -- question is if they are active. Maybe we could also include a list in this thread from those with the expertise to make that determination? Probably a better thread for ADD.

As for trials, it's pretty tough given the effect of set and setting. :/

 

[jahh]

If a substance is active sublingually , it should be just as active rectally? no?