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Misc Are there any dopamine based anti depressants?

H

Harambulus

Greenlighter
Joined
Jul 23, 2009
Messages
624
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In the flow state
My doc advised me a while back to go and see him to get some anti depressansts. At the time he alluded that there a lots of different ones implying that there are plenty to give a try.

At the time I declined as I didn't want another drug dependance.

Since then though I realized I have a habit of drug dependency where I will take whatever I think will give me a release- mephedrone, mdma, whatever other RC is knocking around which I think will fit the bill. I will take one for a bit then be repulsed by it swearing myself off drugs for the foreseeable future but then a month or so later I will start to feel like shit again daily and the thought of drugs as a release creeps into my head as a 'necessary evil'.

So I was thinking maybe an anti depressant would be a lesser of two evils compared to the wild highs and lows of illicit substances.

I'm not really a fan of serotonin agonists. I recently took quite a bit of good quality mdma and I find the high pretty boring tbh. What I like most is dopamine highs, they seem to give me the best sense of contentment which I sorely lack and search for.

So with that in mind would there be any anti depressants which may fit the bill so that I can ask my doc? I might even tell him what I said here that I'm familiar with other drugs and want to stop staking them so want a dopamine releaser to plug the gap.

Ideas?

Also are there any that don't have this long ass 2-5 week warm up period.

I find that a nuisance cos my lows are quite dependant on outside factors such that I may feel great for a week or two but not consistently so.

What would be ideal would be a mild dopamine agonist which didn't have bad side effects so I could take it when I felt an acute stab of depression then not be badly off the next day. Alcohol (not saying that is a strong dopamine agonist just using it as an example) is good in that it's negative effects are dose dependant but unfortunately I fucking hate the effects of it which only make me feel worse.

Lol, after I wrote this I am thinking a dopamine agonist used in a tempered fashion is kind of doomed to fail given the addictive nature of dopamine based drugs. Maybe if it was only mild; mild enough to provide a slight mood lift then it would not be too fiendish.
 
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anti depressent DO NOT get u high AT ALL

they dont even make u feel good, and if u do "feel happier", itl take a few weeds

imo, anti depressents are way to under developed, they havnt been around on this earth long enough to be "the answer"....its placebo IMO, but thats me.

i took lexapro, i stopped (got them stupid withdrawls) and felt better than ever once i quite

they can help for some people, but they certainly will not make u high (thats what it seems like ur asking)
 
have different anti depressents can yield different results for people.. once medication can work on someone, but dont work on someone else..

but in terms on dopamine anti depressents.. they wont get you high, just stablize your dopamine levels in your head

i think wellbutrin(sp?) is a anti depressent that works on dopamine..i heard it gives good results too
back when i was 16-17 i was on zoloft...didnt make any difference for me except my explosive anger kinda went away

i know people that actually got their doctor to prescribe them dopamine reuptake anti depressents so that way it could "even out their drug use" i dont know if there is any facts behind that statement but i assume it would help

i hope this helps..
 
Ye I guess I am looking for a high of sorts.

I would like something I could use recreationally and at acute intervals- i.e non of this 3-5 weeks crap, just as and when so I guess I'd find something more up my street in the illicit market.

I want something MILD. Thing with illicits is I find the comedowns intolerable. I am quite happy to have less of a high and at the same time have less side effects.

I just want something that would give me a mood lift similar to some fun hobby you do, nothing drastic, that I could take of an eve when feeling blue such that it would entertain me for a few hours but also wear off easily without heavy body load allowing me to feel normal the next day.

Just some mild release valve to use only in particular instances (rather than day after day like an anti depressant).

Unfortunately I hate weed (as I imagine this would be the obvious recommendation) as I find it makes my already obsessive thinking loops ten times worse. That and I can't smoke due to allergies.
 
I wouldnt get into serious medication if you are only looking for something Mild and recreational out of boredom.
 
what ur saying..."something that will feel like a good hobby i enjoy"..

the only thing that can mimic endorphin release [which is what happens when your enjoying and happy doing what your doin] is opiates (pain killers)

but i HIGHLY regaurd against taking opiates.

if you do end up trying opiates. do not use more than once every 3-4 weeks...

do not use 2 days in a row, if you do, you're an addict

also, heroin is an opiate, and if you wouldn't do heroin, don't do pain killers

oxycodone is BETTER than heroin, and that is what's in percoset and oxycontin, and many other different brands.
 
I'm prescribed tramadol for depression and I find it helps way more than SSRIs, tricyclics (?) and the like. Obviously it's also abusable (if you like tramadol anyway) but using opiates for depression is not for all - replacing depression with addiction is the trade-off and for most that's probably not worth it. For me, I'd rather function semi-normally than be crippled with depression and tramadol has worked better than any other anti-depressant I've been on.

You really need to discuss it with your doctor and give whatever is suggested a fair trial cos most ADs take weeks to start working properly. What works for one person won't necessarily work for another - SSRIs are poison as far as I'm concerned but they work wonders for others. You need to find out works best for you rather than go in with an idea that you know what you want cos what you want may not be what you need.
 
Shambles said:
I'm prescribed tramadol for depression and I find it helps way more than SSRIs, tricyclics (?) and the like. Obviously it's also abusable (if you like tramadol anyway) but using opiates for depression is not for all - replacing depression with addiction is the trade-off and for most that's probably not worth it. For me, I'd rather function semi-normally than be crippled with depression and tramadol has worked better than any other anti-depressant I've been on.

You really need to discuss it with your doctor and give whatever is suggested a fair trial cos most ADs take weeks to start working properly. What works for one person won't necessarily work for another - SSRIs are poison as far as I'm concerned but they work wonders for others. You need to find out works best for you rather than go in with an idea that you know what you want cos what you want may not be what you need.
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this^^^^
Ive been on every antidepressent with absolutely no luck. I was then prescribed tramadol for jaw pain for 2 months, and it helped decent with the pain, but found it worked wonders on my mood... best anti-depressent i've had. and i use opiates, so i wasn't getting high off them, i just know they do affect seratonin levels, and i think thats why it had a great anti-depressent effect. while you can get high off them, i didn't get much of one, especially the opiate effects with my tolerance, but it definitely helped with depression. i was shocked, and disappointed that i can't get a dr. to prescribe it to me for depression after they've prescribed klonopin to me (more addictive), and rx'd me a million medications which they know made me feel horrible, sick, sometimes suicidal. hopefully i'll get an rx someday to tramadol for my depression... i don't even want to abuse it for a high (i'd need a lethal dose for a high anyways lol), i just want it to not be depressed.
 
NFloyd said:
this^^^^
Ive been on every antidepressent with absolutely no luck. I was then prescribed tramadol for jaw pain for 2 months, and it helped decent with the pain, but found it worked wonders on my mood... best anti-depressent i've had. and i use opiates, so i wasn't getting high off them, i just know they do affect seratonin levels, and i think thats why it had a great anti-depressent effect. while you can get high off them, i didn't get much of one, especially the opiate effects with my tolerance, but it definitely helped with depression. i was shocked, and disappointed that i can't get a dr. to prescribe it to me for depression after they've prescribed klonopin to me (more addictive), and rx'd me a million medications which they know made me feel horrible, sick, sometimes suicidal. hopefully i'll get an rx someday to tramadol for my depression... i don't even want to abuse it for a high (i'd need a lethal dose for a high anyways lol), i just want it to not be depressed.
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yeah i enjoy tramadol for its antidepressant effects and to get high.

however, there is addiction potential and severe withdrawal.

most people just assume that the withdrawals are minor because it's a weak opiate but I think the withdrawal comes from the SNRI (correct me if i'm wrong)
effects. I read a thread here before about someone going through tramadol withdrawal and seemed like he was going through hell.
 
Wellbutrin is an antidepressant that works on dopamine.

some old tricyclic antidepressants might be dopamine agonists, but most are antagonists.
 
I think an NDRI is what ur looking for .
Like a ssri but for dopamine .

U seem like u just want it to get high though which won't work . NDRIS take a few weeks for the effects to kick in .
It's not just something u can take and feel a dopamine rush .

If u want the dopamine rush do some adderall or some sorta stimulant .
Or good olde fashioned excersise ;-)
 
HdoubleODeezy said:
Wellbutrin is an antidepressant that works on dopamine.

some old tricyclic antidepressants might be dopamine agonists, but most are antagonists.
Click to expand...

^This. Wellbutrin is dopaminergic, but don't expect that wonderful mood lift you get from other dopaminergic stimulants. Docs frequently prescribe Wellbutrin for cocaine and even opiate withdrawal because of the slight kick of dopamine it gives...I've taken it before and I can definitely say it is a stimulant--it would keep me awake if I took it too late in the day.
Euphoria? NO! Slight mood lift, more energy? YES!
 
PillPoppingAnimal said:
1 do not use 2 days in a row, if you do, you're an addict

2 also, heroin is an opiate, and if you wouldn't do heroin, don't do pain killers

3 oxycodone is BETTER than heroin, and that is what's in percoset and oxycontin, and many other different brands.
Click to expand...

1: Um.. no, not true.
2: Not all land on Heroin.
3: Um.. no. Opioids like opioids.
 
SSRI's etc affect Dopamine to some extent, but I think Anti-psychotics focus on Dopamine, as they work to stabilize Manic depression and Lithium stabilizes the depressive parts of your personality, I may be wrong someone with more knowledge or time to read Wiki can elaborate more than myself.
 
drugssexandmusic said:
SSRI's etc affect Dopamine to some extent, but I think Anti-psychotics focus on Dopamine, as they work to stabilize Manic depression and Lithium stabilizes the depressive parts of your personality, I may be wrong someone with more knowledge or time to read Wiki can elaborate more than myself.
Click to expand...

A lot of antipsychotics are dopamine antagonists.
 
rollingstoned! said:
You could go on a dopamine antagonist for a month or so and feel shitty and then come off it and feel better. Anyone try this?
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thats ridiculous....

nothing personal, i know you're just wondering, but i hope no one was that desperate to feel "high" that they made themselves "low" in order to feel better
 
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