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Bupe Suboxone/Buprenorphine FAQ & Megathread v2; 2010

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ok a hefty dose of cannabis has made me come up with this theory:

So I told the doctor that I had a 3 year habit with a little bit of heroin, and alot of OC-80 mg a day tollarance) and he told me that I would be dead in 18 months if I continuted to use and told me I should be in a 90 day rehab center on lockdown to me and my mother is this normal for a sub doctor to say? is he just trying to get me on high dose sub the rest of my life? or is he right i believe 80mg is not that big of a habbit for a 19 year old sure. but idk the way he made it sound I will be dead soon lol and yeah i know im an addict of opiates for the rest of my life. but this doesent mean that I will die? opiates arent even damaging to the body really its the addiction/overdose correct/ ugh fucking cannabis rant /end thanks guys :) hope my queztions anserred quickly.

Where do you live?

Here in Sweden you do not have to go too any rehab before entering the program.
Maybe you should go to another Sub-doc?
 
Where do you live?

Here in Sweden you do not have to go too any rehab before entering the program.
Maybe you should go to another Sub-doc?

united states no he was recommending my mother take me to one. i think he was just trying to scare her into keeping me on sub because i know it will help. so i hope he kinda is lol
 
Today is my third day on subs and off oxy.

Day 1, I took 20mg. Yesterday I took 16 mg. This morning, I took 8 mg to start the day (about 3 hours ago). I've been feeling good, but am wondering what the minimum dose to be effective is.
 
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"Low dose "buprenorphine is NOT good for addicts who want to stay off heroin, The whole point and advantage of subs is it blocks opiates at highish doses and this kills the mental cravings. If you whittle down to 0.5mg and the like , theres no deterant from relapsing. recreation , sure , low is better but if you go on SMT stay at a high dose , at least 8mg then you need to wait a few days and hopefully the temptation will be gone to use H.

Im sry but this is just rediculous. When you are on low dose suboxone you are experiencing more full agonist properties which give you more euphoria, energy, etc.......This makes it MUCH easier to keep your mind off of using heroin or oxy or whatever again. If your mind and body is allready completely happy because you are allready experiencing pleasure, then you are much less likely to go searching for pleasure in other drugs.

"When you whittle down to 0.5mg, theres no deterrant from relapsing"

I wonder have YOU EVER "whittled down" to 0.5 mg's and stayed at that dose for a long period of time? There is MUCH MORE of a deterent at that dose than at higher doses. Not only does it make you not feel sick, but it also makes you feel pleasure. At high doses all you feel is normal, and sometimes get a headache.
 
It usually takes people a higher dose of suboxone to stave off the withdrawals when initially switching to subs from heroin or oxy or some other strong opiate(Allthough when I switched from IV'ing a shitload of black tar heroin for over 4 years to suboxone, all I needed was 2mg's.....doctors CONSTANTLY overprescribe suboxone, which, in turn, causes the patient to THINK they need that much suboxone, whe they really dont). But, after only a couple days on the subs, long enough for the heroin/oxy/etc to get out of your system completely, you can very easily lower your dose dramatically, and immediately(sometimes it takes a few days but mostly you can do it immmediately).....to a lower dose of about 2mg's give or take. And then from there, you can also very quickly lower your dose to under 1mg, which is the dose level where you start to see the full agonist effects of the subxone, because norbuprenorphine(the full agonist metabolite of bupe) is only actifve when the subs are taken in such tiny doses. It may take a few days or even a week or two at most for you to start enjoying the "low dose euphoria", but once you finally do stabilize on that low dose, you will feel like a fool for ever wanting to take any dose higher than a single milligram.

Many people simply arent aware of this low dose phenomenon or they choose not to believe it, so they end up being on a very high dose of suboxone for such a long period of time to where it can sometimes take a much much longer time to actually get down to that under 1mg dose and enjoy its benefits once they finally decide to give it a try. I am constantly hearing people complaining to me about how...."I dropped from 24mg's/day to 1mg/day and I got withdrawals and you are wrong!!!!".....well, my answer to those people is you need to drop to that low dose in the correct manner for it to work. Also, you need to stay at that dose for more than a couple days before you can make a judgement on whether or not suboxone can actually cause euphoria at low doses. It all has to do with maintainence. Dropping from 24mg's to 1 mg immediately, isnt going to produce euphoria until you give your body a couple weeks to adjust to the new dose level and get rid of all that built up bupernorphine thats in your brain. Remember, bupe has a very long half life, and if your taking huge doses of sub every day, it can build massive amounts of it up in your body.

*So to answer your question..."...so why isnt 0.25 - 0.5mg's enough to stave off withdrawals and keep people maintained".....it actually IS enough to do that. I take 0.5 mg doses every day, and not only am I maintained, but I get all the euphoria and ohter benefits as well. This is because those people need to get down to that 0.25mg or 0.5mg dose in the correct manner. If you have any other questions, as I know this subject can be very confusing, please feel free to ask away....im here to help, and I will do my best.

I'm not disputing this works for you because there no reason for you to purposely mislead others. I also know there's at least one or two others who make the same claim.... so you have some backup.

However, from what I understand, you guys IV your dose... correct? And you dose at least 3-4 times a day... right?

I say this because I've tried this low dose method two ways... IV and sublingual. I even bought and used all the specific supplies for IV and micro-filtering. [Whatman Micron Filters, Luer Lock syringe/tips, Bacteriostatic Water, pre-sealed vial, and 31g tips/syrynges] I can verify this if needed. Anyway, I was on .50mg sublingual [ once a day] at the time and was not getting any euphoria so thats why I tried the IV method. The only significant difference I noticed between IV and Sublingual [1/2mg subs] was that my mild wd [irritability, low energy, watery eyes] went away faster. Nothing you could call an IV "rush". It only took a minute or two IV verses 15-20 mins sublingual to feel effects... and to be fair, I probably felt a little better for a short period but found the the mild WD's came back sooner than the sublingual dose. IV didn't hold me as long. I also wasn't interested in IV'ing several times a day so I only used the this method for a few days. But I had already been on the .50mg for 6-8 wks before trying IV.

The bottom line for me was that I didn't get high with IV or feel anything much different than my regular 1/2 mg sublingual dose. And if your system works... it would seem that it wouldn't matter what ROA your use anyway after it hits your CNS. BTW, I'm curently on 1mg sublingual [and have been for several mos] which translates to about 1/3mg bioavailability and all I get is a bit of energy boost and no WD's. If it makes any difference, I was on methadone for about 15yrs before switching to subs 3/2009

Once again, I'm not disputing what works for you [or others] but to say or imply it works for everyone... is simply not true. Not looking for an arguement but I suspect you guys are in the minority rather than majority? And I'm extremely envious...

To try and get some anecdotal info [one way or the other] I've been in contact with CapH and hopefully we'll put a survey online here which could give others the opportunity to give their own experience... we'll see it that happens... or is even possible at BL.
 
Im sry but this is just rediculous. When you are on low dose suboxone you are experiencing more full agonist properties which give you more euphoria, energy, etc.......This makes it MUCH easier to keep your mind off of using heroin or oxy or whatever again. If your mind and body is allready completely happy because you are allready experiencing pleasure, then you are much less likely to go searching for pleasure in other drugs.

"When you whittle down to 0.5mg, theres no deterrant from relapsing"

I wonder have YOU EVER "whittled down" to 0.5 mg's and stayed at that dose for a long period of time? There is MUCH MORE of a deterent at that dose than at higher doses. Not only does it make you not feel sick, but it also makes you feel pleasure. At high doses all you feel is normal, and sometimes get a headache.

Before I was down to 1-2 mg per day and maintaining on 4-8 SL I didn't crave any other drugs at all. Now that I'm down to the 1-2MG I undoubtedly crave A LOT MORE... So much in fact that I bought ten OP 80's a couple days ago..

And they are just about gone.

But that's just me. Everybody is different.
 
I hear people talking about slashing there suboxone up into tiny tiny peaces while tapering down. how small of doses do i have maintain before i could get off of subs completely? (with out any WD of coarse.)

from what ive read, it sounds like very very tiny peaces, like smaller than 1/8 of a sub = .5mg right?

whats the deal with these fucking things. why are they so hard to get off of. it sounds ridiculous to have to keep breaking up my suboxone into such tiny peaces. im thinking it would just be easier to wean off of opiates?
 
Hmmmm thats a pointless rule...

But what would you say is a good dose for someone with zero tolerance, half a milli? I wana nod harD

<3
 
I'm not disputing this works for you because there no reason for you to purposely mislead others. I also know there's at least one or two others who make the same claim.... so you have some backup.

However, from what I understand, you guys IV your dose... correct? And you dose at least 3-4 times a day... right?

I say this because I've tried this low dose method two ways... IV and sublingual. I even bought and used all the specific supplies for IV and micro-filtering. [Whatman Micron Filters, Luer Lock syringe/tips, Bacteriostatic Water, pre-sealed vial, and 31g tips/syrynges] I can verify this if needed. Anyway, I was on .50mg sublingual [ once a day] at the time and was not getting any euphoria so thats why I tried the IV method. The only significant difference I noticed between IV and Sublingual [1/2mg subs] was that my mild wd [irritability, low energy, watery eyes] went away faster. Nothing you could call an IV "rush". It only took a minute or two IV verses 15-20 mins sublingual to feel effects... and to be fair, I probably felt a little better for a short period but found the the mild WD's came back sooner than the sublingual dose. IV didn't hold me as long. I also wasn't interested in IV'ing several times a day so I only used the this method for a few days. But I had already been on the .50mg for 6-8 wks before trying IV.

The bottom line for me was that I didn't get high with IV or feel anything much different than my regular 1/2 mg sublingual dose. And if your system works... it would seem that it wouldn't matter what ROA your use anyway after it hits your CNS. BTW, I'm curently on 1mg sublingual [and have been for several mos] which translates to about 1/3mg bioavailability and all I get is a bit of energy boost and no WD's. If it makes any difference, I was on methadone for about 15yrs before switching to subs 3/2009

Once again, I'm not disputing what works for you [or others] but to say or imply it works for everyone... is simply not true. Not looking for an arguement but I suspect you guys are in the minority rather than majority? And I'm extremely envious...

To try and get some anecdotal info [one way or the other] I've been in contact with CapH and hopefully we'll put a survey online here which could give others the opportunity to give their own experience... we'll see it that happens... or is even possible at BL.

First of all, yes, you being on methadone for 15 years before switching too suboxone very well could have made a HUGE difference on how your body responds to suboxone(or any opiate). In fact, being on MMT for that long could have actually fucked up your brains receptors to the point where the damage was too much to repair over time. I really dont know, but I think that the whole 15 years of methadone thing can make a big difference, allthough I admit that there is no way I can know for sure if it is affecting this suboxone scenario, but my guess is that it is.

Also, i never said that my method works for everyone. Im constantly saying that everyone is different and responds differently to everything. Its just the way humans are.

I, like you, am also not trying to argue, or show any disrespect. the reason I get on Bluelight every day(almost) and talk to people about lowering there suboxone doses so they can experience euphoria is because I have learned of a way to take subs that works for me(and others) that actually does allow for all these beneficial side effects and I want others to ATLEAST give it a try. I realize that it may not work for some people. This may be because a persons brain is wired very differently, or someone simply just doesnt follow my method correctly and doesnt give it enough time to adjust so he/she can experience the pleasure, or maybe it doesnt work for some people because thats just how it is....they just cant get euphoria from suboxone because thats how they are. It could also have emotional reasons as well....emotions are extremely good at affecting people physically (i.e. people who are depressed lots of times look sick)....so if someone isnt in the right place emotionally, or mentally, suboxone might not be able to work for them like it does me.
I just give the advice in hopes that people will benefit from it. No where did I say that this will work for everyone. but I do believe that if enough people actually were able to follow my advice very closely, you would see that this actually DOES work. All it takes is one little thing wrong to mess it up sometimes. Like, you, for example......it may not have worked for you because maybe you are the type of person whose brain needs the suboxone to be delivered rapidly for it to cause any euphoria. So while you were at the low 0.5mg dose taking it SL, it wasnt getting to your brain fast enough. But when you switched to IV, you actually noticed a difference, but you didnt give it a long enough chance. You gave up IV'ing after only a few days, when maybe you should have tried giving it more time so you could adjust to this new method. I know you said you didint like hving to IV a few times a day, but unfortunately, with low dose suboxone, sometimes you do have to dose a few times a day. Theres just too much information that I have to say that I just dont have the time/effort/or space to type in a post.

Also....you said..."you guys IV your dose right?".....well, yes I do IV my dose alot. But I actually snort it, plug it, and take it sublingually as well. And all different ROA's have different "feelings" about them. For example, plugging is the most euphoric ROA in my opinion and it lasts a very long time, resulting in me only having to dose once in a day.

I also reccommend low dose suboxone because the less of a drug you have to take the better. The less negative side effects you have, etc...And, even if someone isnt trying to get euphoria from there suboxone, even if they dont care about getting any energy boosts from it, taking a low dose makes it MUUUUUCH easier and quicker to get off of subs in the end whenever you choose.
 
Hmmmm thats a pointless rule...

But what would you say is a good dose for someone with zero tolerance, half a milli? I wana nod harD

<3

Im not sure what "rule" your talking about.

Also, if your asking how much suboxone to take if you have no tolerance.....then i would definitely reccommend 0.4-0.7mg's sublingually. It should knock you on your ass. Atleast thats what it did to my opiate naieve friends.
 
Before I was down to 1-2 mg per day and maintaining on 4-8 SL I didn't crave any other drugs at all. Now that I'm down to the 1-2MG I undoubtedly crave A LOT MORE... So much in fact that I bought ten OP 80's a couple days ago..

And they are just about gone.

But that's just me. Everybody is different.

Well, Tamgesic, the "painkilling drug" form of bupernorphine comes in doses of 0.2 to 0.4 mg's. Maybe you should try lowering your dose to under 1mg. Maybe at the dose your at, your filling up most of your receptors with bupe instead of leaving enough receptors open for norbupe. If you choose to do this, I would give it atleast a couple weeks to see if you start to "crave" less, and you may also have to dose more than once a day, maybe not, but in my opinion, throwing a little orange chunk under your tounge for a couple minutes isnt that big of a deal.
Im sry you still feel cravings. Your right, everyone is different, and I hope you figure out the right dose/lifestyle/etc to make it where you dont feel the need to get high all the time. Good luck.
 
new suboxone formulation

not sure if this has been posted, but I just got an e-mail from the makers of suboxone:
If you're working to overcome opioid dependence, you know the experience can sometimes be overwhelming. That's why the formulation of your medication should help make your experience convenient. Some patients have shared their concerns about taking SUBOXONE® (buprenorphine and naloxone) sublingual tablets (CIII), such as:

The time the tablets take to dissolve

The difficulty of traveling with them

Their taste


Consider a treatment that may make your experience more comfortable and convenient.
SUBOXONE Film, a new formulation of SUBOXONE, may improve your daily treatment experience. And clinical trial patients tell us they prefer SUBOXONE Film to the SUBOXONE Tablet.1a

SUBOXONE Film is indicated for long-term treatment of opioid dependence and should be used as part of a complete treatment plan that includes counseling and support.

SUBOXONE Film delivers:

An evolved patient experience

- Faster to dissolve than SUBOXONE Tablet1b

- A favorable taste rating (more than 71% of patients scored the taste as neutral or better)1c

- Individually wrapped in compact unit-dose pouches that are child-resistant1d and easy to carry1e

- Once-daily dosing (just like the SUBOXONE Tablet)2

- Clinically interchangeable with SUBOXONE Tablet, so your doctor can transition you. Your doctor should monitor you for overmedication3

Built-in support from the Here to Help® Program that can help make treatment success more likely4
 
Well, Tamgesic, the "painkilling drug" form of bupernorphine comes in doses of 0.2 to 0.4 mg's. Maybe you should try lowering your dose to under 1mg. Maybe at the dose your at, your filling up most of your receptors with bupe instead of leaving enough receptors open for norbupe. If you choose to do this, I would give it atleast a couple weeks to see if you start to "crave" less, and you may also have to dose more than once a day, maybe not, but in my opinion, throwing a little orange chunk under your tounge for a couple minutes isnt that big of a deal.
Im sry you still feel cravings. Your right, everyone is different, and I hope you figure out the right dose/lifestyle/etc to make it where you dont feel the need to get high all the time. Good luck.

Thanks! That's the goal - to get that low. It's taken me four months to get to .5-1MG so after this little excursion I'm going to try and get even lower.

When it comes time to taper off completely I'm going from sub, to oxy, to vicodin, to codeine, then to ZERO. I estimate it will take about a year or more but then I should be OPIATE FREE, relatively painlessly.

Of course this all may change as I just found out that I need nerve surgery. The specialist that my Sub Dr. referred me to took one look at me, then one look at my x-rays and proceeded to write me a large script for 10/500 Lortab without me saying a word.

I'm going to walk into my Sub Dr's office with the whole bottle at my next appt. and see what he has to say. I have no clue what he has in mind to manage the pain I'm in now. He said he can't say anything until after he gets the results back from another specialist I'll be seeing tomorrow..

Anybody been in a scenario like this before? Any suggestions?

BTW - These OP 80's are certainly a PIA to abuse but they work wonderfully for pain. And they last a really, really long time. I'm pain free for a good 12 hrs w/ one 80.
 
You must be confused. Im sry but it is not "theory". Bupernorphine, in fact, has a higher binding affinity than most other opiates known to be taken by man, including its metabolite, norbuprenorphine(full agonist). And its also fact, that when you take small enough doses of bupe, you leave receptors open for its metabolite to bind to, when it would otherwise NOT bind at higher doses of bupe because there are no more receptors left....and as I explained above, the norbupe cannot kick the bupe off of its receoptors. So when taken in small doses, bupe leaves enough receptors open for its metabolite to bind. Its a very simple concept that actually is based in fact. Im not sure where you got the idea that it is only a theory.
Maybe you should do a bit more research into the exact functions these different chemicals have inside our brains....heres a good website that has alot of good information about this very same subject....give it a good read through, and I think it might clear some things up for you....

http://jpet.aspetjournals.org/content/297/2/688.full

I'm very well familiar with that paper, and I'm still not sure how you are extrapolating what you've been saturating these boards with as fact. Fact is laughable....in neuropharmacology there are precious few facts. Receptor binding affinities IN VITRO are fact, yes, but as to what happens IN VIVO in the human brain we are pretty much dependant on theories. I'm just asking for a source, as I and many others have over the past few years, and there isnt one. Im not saying these theories aren't plausible, they are, but they still remain theories. What is established as fact (see the R+B trials with buprenorphine) is that buprenorphine is dose dependant in a linear fashion. Norbuprenorphine is created metabolically, via enzymes.........look how it is excreted. The time line and numbers leave a little to be desired for this theory to become fact. Throw this theory to a neuropharmacologist....they will probably respond just as we have on this board over the years when somebody gets zealous and opts to post hundreds (if not thousands) of posts telling people how it is. It gets tiresome. I see why most dont even bother to try to post sensible refutes anymore. It happens every few months around here. Carry on.....
 
I'm very well familiar with that paper, and I'm still not sure how you are extrapolating what you've been saturating these boards with as fact. Fact is laughable....in neuropharmacology there are precious few facts. Receptor binding affinities IN VITRO are fact, yes, but as to what happens IN VIVO in the human brain we are pretty much dependant on theories. I'm just asking for a source, as I and many others have over the past few years, and there isnt one. Im not saying these theories aren't plausible, they are, but they still remain theories. What is established as fact (see the R+B trials with buprenorphine) is that buprenorphine is dose dependant in a linear fashion. Norbuprenorphine is created metabolically, via enzymes.........look how it is excreted. The time line and numbers leave a little to be desired for this theory to become fact. Throw this theory to a neuropharmacologist....they will probably respond just as we have on this board over the years when somebody gets zealous and opts to post hundreds (if not thousands) of posts telling people how it is. It gets tiresome. I see why most dont even bother to try to post sensible refutes anymore. It happens every few months around here. Carry on.....

I'm thinking it's probably fact based solely on the existence of Tamgesic 0.2/0.4.

Of course I could be wrong -- I often am.
 
^^ if that is the lynchpin for becoming fact than yikes...........

Temgesic (which im assuming is what you guys are calling Tamgesic) was made at those doses because it was created back when buprenorphine was found to be 32x stronger (this number varies, this was the first) than morphine as a mu agonist, thus, a 10mg/ml morphine injection (standard back then) would be a 300 mcg/ml buprenex vial. 200 mcg sublingual tablet was seen as a convenient dosage form. I don't see how you guys are using this as "proof" of this whole bupe/nor-bupe craziness?
 
I'm thinking it's probably fact based solely on the existence of Tamgesic 0.2/0.4.

Of course I could be wrong -- I often am.

I dont know.....the fact that I and many other people who actually correctly attempt the suboxone dosing methods I have mentioned experience these beneficial effects is fact enough for me to try to tell people to attempt it. I never stated that it is a fact that everyone who does it will get high like me and mthe many other people who do. The only things Ive claimed as facts are the binding affinities of bupe and norbupe.....nothing else. I then go on to say that I feel high as a result of a manipulation of my dose levels in the correct fashion, time periods, etc....you would think that the FACT that bupe is ONLY made in "painkiller form" as Tamgesic in doses of 0.2-0.4 mg's is enough evidence to support what im saying but some people like to play devils advocate. And thats fine, but just because they dont want to believe somehting doesnt make it false.

Also.....amanitadine has been consistently trying to accuse me of spreading false information for soem reason alot lately. Im not sure why. Like I said above, I only claim the binding affinities of these drugs as facts, everything else is just personal experience. And that is all that is needed to tell someone to give it a try because they very well may get euphoria from suboxone as well. Just like someone telling someone else how much oxy to take on there first try to get them high.....it isnt a FACT that the dose you tell them to take will do anythign to them, its just coming from your experience, and the experience of others....yet people everyday on BL are giving that same advice to people all the time. But for some reason he chose me to bitch to about giving advice in hopes of bettering peoples lives. Amanitadine needs to re-read what I stated as fact, because I think hes a little off base.
 
I've been getting two-three of these every other day for the last month!

Really! I'm happy to hear it, especially if you're on the east coast. I want to ask my dr to switch me to these, but then again as I type this I sniff them, I could just put it up my nose, but hmm....
 
Really! I'm happy to hear it, especially if you're on the east coast. I want to ask my dr to switch me to these, but then again as I type this I sniff them, I could just put it up my nose, but hmm....

you say you want to switch to the strips?

im just curious, what appeals you to them so much that you want to switch over? is it the fact its easier to dissolve in your mouth?

im just wondering what peoples opinions are on the new formulation
 
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