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4-F-MABP, 4-MeO-PBP, 4-Et-PBP, 3-Me-4-MeO-MCAT, 4-Me-EABP

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any major dude said:
These utterly unresearched stimulants make me nervous. I feel like we're just waiting on another MPTP type disaster...
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It'll only be worse with these, as the MPPP/MPTP disaster was at the very least a synthesis mistake. What I fear is that the "RC community" will stumble upon another para-chloroamphetamine (PCA) or 4-methylthio-amphetamine (4-MTA) and a few "guinea pigs" will start at what they think are recreational type doses and get the rough edge of unpleasant effects in full force. Shulgin worked with some compounds that seemed likely to be toxic in higher doses, but his gradual and careful up-titrating averted any 'disasters'. The introduction of these new compounds isn't being treated with the same respect by many. At least we have some knowledgeable people here who may "foresee" something with effects as harmful as 4-MTA before it kills.
 
If Shulgin were to have experimented with para-chloro-amphetamine, his procedure wouldn't have necessarily averted folly. In this chemical's case, neurotoxicity doesn't correlate with unpleasant subjective effects while high. When known SAR indicates plausible neurotoxicity, I'd steer clear of even Shulginesque dosing.

ebola
 
Because the number of aromatic substituted chlorines in the prescription drug pharmacopeia is so staggering, I remain skeptical of para-chloroamphetamine's purported neurotoxicity beyond that of non-halogenated amphetamine.
 
So far it seems that there is something characteristic about solo para substituted amphetamines that tends towards neurotoxic disadvantages and/or hyperthermic issues.
4-MTA is said to be non-neurotoxic by D. Nichols though it is known for causing adverse effects very similar to those of PMA which are supposedly caused by strong MAOI activity.
Though as I mentioned above theese issues seem to be prevalent in solely para substituted amphetamines (with beta keto and N-methyl analogues being even more dangerous IMO).
 
<pyridinyl_30> said:
Because the number of aromatic substituted chlorines in the prescription drug pharmacopeia is so staggering, I remain skeptical of para-chloroamphetamine's purported neurotoxicity beyond that of non-halogenated amphetamine.
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it has pretty specific neurotoxic effects on serotonergic neurons, IIRC. neuronal pruning was the term, IIRC. Regular amps are nothing similar
 
IIRC
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You do. I wanna say that Nichols found such in some of his early research, but I don't have the study handy...and might be mistaken. I also know that the effect seems distinct from the type of serotonergic neurotoxicity that we see with mdma; it's something more than simple concurrent 5ht and DA release coupled with moderate formation of free-radical metabolites.
 
stom10 said:
It'll only be worse with these, as the MPPP/MPTP disaster was at the very least a synthesis mistake. What I fear is that the "RC community" will stumble upon another para-chloroamphetamine (PCA) or 4-methylthio-amphetamine (4-MTA) and a few "guinea pigs" will start at what they think are recreational type doses and get the rough edge of unpleasant effects in full force.
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Wouldn't methedrone fall into that category? We were lucky there weren't many deaths with that one.
 
How would you expect the effects of the 3-methyl substituted analog of 4-Methoxymethcathinone to differ from its parent compound?
 
atara said:
Wouldn't methedrone fall into that category? We were lucky there weren't many deaths with that one.
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I somehow doubt it was as bad as has been said. Its still for sale a few places, but evidently the reputation makes it not popular enough to cause problems.
 
Possibly trippy / entactogenic / stimulatory.

Then again, no one can predict this kind of stuff with anything approaching 100% accuracy.
 
That being said, seeing 4-Et-PBP on this list has me mildly excited. (I've always wanted to try 4-Et-amphetamine.)
 
Saucy said:
I mean 3-methyl-4-Methoxymethcathinone vs. 4-Methoxymethcathinone.
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Ignoring subjective effects (like 'more of an empathogen' and other speculative bull like that), if its anything like the change from 4-MeO-amphetamine (PMA) to 3-Me-4-MeO-amphetamine, it will be different. That's really all we can say. 3-methylating removed the MAOI properties of PMA (but its debatable whether bk-PMMA ever had these at all and anything else is pure speculation unless there's SAR data to back it up). As seems to be the current attitude of RC enthusiasts, dosing will be the only way to find out. I wouldn't bother with it, but if you must, start low (like a few milligrams low) and don't just keep piling more on within the same night to reach the active dose.
 
atara said:
3-methyl-4-methoxy? Those morons got the goddamn compound backwards!



Don't worry, anything with a butyrophenone suffix is going to be completely and entirely, unquestionably, without a doubt worthless, recreationally-wise.

Butylone was okay. Just okay, though.
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I must respectfully disagree. I know some who consider alpha-pyrrolidinobutyrophenone to be a worthy chem. i can imagine the 4-meO version could be as well.....


Interesting bit of trivia: butyrophenones are a class of drugs that includes antipsychotics such as haldol. Ironic to anyone who has vaporized a-pbp freebase, I assure you.
 
Fuck all this pissing around, lets just skip to the end shall we:

ANNOUNCING THE NEW CATHINONE ANALOGUE: SHITYOURPANTSDRONE (WE CALL IT BARK BARK):

MgzPW.jpg
 
MagickalKat777 said:
They are synthed and they are coming - any idea on the effects? The 3-Me-4-MeO-MCAT looks like it could be interesting... not too keen on more 4 positions hitting the market and I'm not sure about more pyros either. 4-Me-EABP is probably just a weaker version of 4-MeMABP but you guys are the experts not I.

Chem names: 4-fluoro-methylaminobutyrophenone - 4-F-MABP
4-Methoxy-Pyrrolidinobutyrophenone - 4-MeO-PBP
4-Ethyl-Pyrrolodinobutyrophenone - 4-Et-PBP
3-Methyl-4-Methoxymethcathinone - 3-Me-4-MeO-MCAT
4-Methyl-ethylaminobutyrophenone - 4-Me-EABP
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We really need to have a slang thread, I don't know what any of this means....
 
If you don't know what it means you shouldn't be even considering touching the stuff. You see most of the intellectual heads in here not wanting to dive into them, so neither should you if you know what's good for
 
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