• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Nigella seed actives-thymoquinone

L

Limpet_Chicken

Bluelighter
Joined
Oct 13, 2005
Messages
6,322
Location
UK
Recently I have been reading more about the plant mentioned in the title, the seed of Nigella sativa (black onion seed, black seed), the little black aromatic seeds so often found on naan breads.

Anticancer/antiangiogenesis properties aside, they appear to be a painkiller, the active compound, thymoquinone reminds me almost of propofol, structurally, odd mechanism of action from the looks of it, anybody know what? it potentiates opioids apparently (I am about to find out, I think:D) but shares no crosstolerance in morphine-dependent rats, but appears to provide at least a good deal of relief to some poor murine souls that were made forcibly morphine dependent, then made to withdraw.

Endocannabinoid reuptake inhibitor? FAAH inhibitor? other fatty acid amide hydrolase inhibitor? enkephalinase inhibitor?

I am currently partway through ingesting around 6g of seeds, after grinding and pulverising to a fairly oily, gritty powder in a mortar and pestle, and mixed in golden syrup to a thick paste.

Quite delicious actually, far better than most drugs turn out to be.

To be followed by a moderate dose of dihydrocodeine tartrate in a short time to allow action.

My theory is that it is an enzyme inhibitor, possibly acting on either the endocannabinoid system or on enkephalinase.

Thoughts? experiences?

Not to mention, this concoction is so tasty, I could really bake it into the crust of some sweet honeycakes, or a sweet, heavy bread glazed with honey and maple syrup and eat it for breakfast, hell, maybe with poppy seeds=D
 
N. sativa is actually a very important medicinal herb in the Middle East. The problem is that there are several different plants that carry the name N. sativa, so it can be frustrating. Furthermore, the most commonly available one (that you can get in ethnic food supply stores) is usually the inactive one - what you want is the long, thin black seed, not the small roundish one.

Now, when properly identified, this stuff WORKS! We prepare it by grinding it in honey, that way the volatiles are dissolved. It is then taken orally. But even with that R.O.A., there is a RUSH of wellbeing. It literally stops all the symptoms of the flu. It has analgesic and anxiolytic effects, and given the essential oils' closeness to Propofol, I'd bet it is at least partially GABAergic.

In my subjective experience, I HIGHLY doubt it is cannabinoidergic.

What's more, I have found it to produce some kind of synergy with Ketamine so as to make the experience very euphoric.

I don't recommend baking because the active constituents seem to be volatile.

To my knowledge, I had assumed that Thymol (another propofol lookalike) was responsible for the therapeutic effects. Thanks for pointing out Thymoquinone.
 
Jamshyd said:
In my subjective experience, I HIGHLY doubt it is cannabinoidergic.
Click to expand...

I thought there was a suggestion that propofol itself has some kind of endocannabinoid activity. (I admit that might just be wikipedia on looking it up)
 
Isn't thymol one of the ingredients in Listerine? Who knew the rich old ladies who sneak a buzz off of mouthwash had it right all along? In all seriousness, Jamshyd you make it sound quite pleasant. I like subtle mood lifts. When I eat a whole fresh turmeric root I get a very noticeable mood lift, perhaps just from my joints being less painful. I've always felt that removal of physical pain can sometimes translate into an emotional boost.
 
Turing Machine said:
Isn't thymol one of the ingredients in Listerine? Who knew the rich old ladies who sneak a buzz off of mouthwash had it right all along? In all seriousness, Jamshyd you make it sound quite pleasant. I like subtle mood lifts. When I eat a whole fresh turmeric root I get a very noticeable mood lift, perhaps just from my joints being less painful. I've always felt that removal of physical pain can sometimes translate into an emotional boost.
Click to expand...

thymoquinone
 
^ But Thymol is in fact another constituent of Nigella, and it is active and AFAIK known to be GABAergic (but very short-lasting) as well as antimicrobial and antioxidant.

And yes it is in the yellow listerine, and yes that is actually the only mouthwash I personally use :)
 
Well that trial appeared to be very successful.

Normally I would need to redose on my pain meds a few times daily.

Today? not once, after taking my morning dose, and no withdrawals, in fact, after taking my DHC after about 8:30am, it is 12:30PM here and I am still experiencing ptosis and am fairly buzzed and sedated.

Next? I think I am going to try and reduce my tolerance to next to nothing, and also try the expressed oil and essential oil. Although 6g of ground seed had substantial effects.
 
would pure black seed oil produce the same effects as the seeds? i am deciding which one i want to buy
 
Sounds very pleasant and a great reason to visit the local Indian spice dealer!

The longer, thinner seeds you talk of would look more like this:

JINTAN_HITAM_2.jpg


as a posed to rounder ones:

http://www.theblessedseed.com/images/464020915_32f97da18c.jpg

@poppyllama I would assume unless you could guarantee the oil was made from the active seed it would do nothing.
 
^ Exactly!

IME, these are more difficult to find, and it is compounded by the fact that there is even a third variety of identical-looking thin seeds with a lighter colour that doesn't seem to be active either (ALSO called N. Sativa :().

I've been dying to find the one that cured my flu... it appears to be impossible to find, particularly that most people use it for flavouring and as such the small black seeds are actually more desirable.
 
Jamshyd said:
^ Exactly!

IME, these are more difficult to find, and it is compounded by the fact that there is even a third variety of identical-looking thin seeds with a lighter colour that doesn't seem to be active either (ALSO called N. Sativa :().

I've been dying to find the one that cured my flu... it appears to be impossible to find, particularly that most people use it for flavouring and as such the small black seeds are actually more desirable.
Click to expand...

you clearly know your shit, find out more as you have intrigued me hugely=D
 
Jamshyd said:
^ But Thymol is in fact another constituent of Nigella, and it is active and AFAIK known to be GABAergic (but very short-lasting) as well as antimicrobial and antioxidant.

And yes it is in the yellow listerine, and yes that is actually the only mouthwash I personally use :)
Click to expand...

are you saying i can get high off yellow listerine?

i thought it had other ingredients that were harmful to ingest(not harmful in a good way).
 
My question remains, is this known to have any actions on enkephalinase? my suspicions are strongly that it does.

I have had no withdrawals at all up to now, since dosing at 8.30am yesterday. I have been taking a minimum of 130mg of dihydrocodeine for several years now.
 
Who wants to plug a bottle of listerine and report back.

Psst...no sources, but you can find it in many places in public high streets, I heard the yellow one is the good shit.
 
^ Hahaha.

StaySedated said:
are you saying i can get high off yellow listerine?

i thought it had other ingredients that were harmful to ingest(not harmful in a good way).
Click to expand...
a. No, you can't get high. But it is definitely the most effective mouthwash that I've used.

b. It contains, among other things, eucalyptol and Methyl Salicylate, both toxic to take internally, particularly the latter.

c. You can't get high on Nigella either - it's just damn good medicine and appears to enhance other drugs.

Limpet_Chicken said:
My question remains, is this known to have any actions on enkephalinase? my suspicions are strongly that it does.
Click to expand...

I would say, from subjective experience, that this is far more likely the case than cannabinoid action. It is also more plausible as N. sativa is believed (and I agree with said belief) to boost immune response - something we typically see with elevated endorphins.
 
Hm, I just witnessed an interesting to N.sativa seed.

The seed was ground and eaten by my housemate, who mind you is EXTREMELY sensitive to pretty much all drugs (she is autistic, has some wierd phamacological quirks, and can begin to trip from handling dried mushrooms, has visuals from sumatriptan, DMT lasts as long as psilocybin does, and the time she ate a quarter oz of strong herb in one sitting, she hit the deck for a week straight)

What followed was strange indeed, ptosis, uncontrollable giggling and euphoria.

Didn't last long though, and a very small amount of seed was eaten, 4.8g or so, coarsely ground and pulverised with a mortar and pestle then crushed between pliars.

Then as it tapered off, restless ensued (akathisia possibly???) which was terminated by administration of 10mg temazepam, and some stomach upset, although the latter isn't saying much as her digestive system hates spicy food of any kind, whereas I actually like drinking habanero tabasco sauce by the bottle.

Knowing her responses generally are the same, but of much greater duration when less of a given substance is taken, my guess is one could indeed get high on nigella or its oil, but larger quantities than expected may have to be taken.
 
I manage to locate a litre bottle of the oil by Makana. Think it may be on Amazon. Veering close to source discussion so i'll say no more. It contains both black seed and black cumin so its safe as houses really. I believe Black cumin is what you want. It contains both anyways so you may need to take a little more since a teaspoon would logically contain an equal mix of both oils.
 
Thymoquinone is available in pure form from a popular site. It's supposed to be an opiate of some sort or opiate potentiator...
 
You must log in or register to reply here.
Top