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  • BDD Moderators: Keif’ Richards

Stimulant affinity and cross-tolerance

Soap MacTavish

Soap MacTavish

Bluelighter
Joined
Jul 12, 2010
Messages
293
I know with opiates, one can stop heroin withdrawal with an equivalent dose of oxy, substituting a natural molecule with the synthetic, and vice-versa. It all boils down to equivalence and the opiod receptors.

Does the same apply to stimulants? For example could one stop their coke withdrawals with synthetic amphetamine? Could one stop their amphetamine withdrawal with MDPV or Mephedrone? Does it all boil down to equivalence with stims too?
 
well coke, amp, ritalin are cross tolerant. idk about mdpv, mephedrone, or any other empathogens. its possibe that they are somewhat cross tolerant with coke, amp, etc., but empathogens also have effects on serotonin release and serotonin receptor agonism.
 
Cocaine and Amphetamines are probably cross tolerant. Methlyone and MDMA (from first hand experience) are somewhat cross tolerant. I kinda stopped doing stimulants after abusing MDMA, blow and meth (and methylone a couple of times) and never got into the RCs of today.
 
hm, well, it appears that MDPV is strong enough to totally overpower my adderall comedown completely and erase it. It's definitely no replacement for amps though, not a very friendly substance.
 
Soap MacTavish said:
hm, well, it appears that MDPV is strong enough to totally overpower my adderall comedown completely and erase it. It's definitely no replacement for amps though, not a very friendly substance.
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well, yeah it will overpower your comedown with it's high. then you'll have a mdpv comedown on top of the original adderall comedown. not good...8)
 
well, for the last 3 days previous to the PV I was able to stay alive on 50mg adderall daily, which is my target. When I get that script refilled on Tuesday I am dumping the PV and going through the shit getting back on my therapeutic dose. Fuck withdrawal, I'll beat the shite out of it and hang it up to dry.

no, seriously, I'm bullshittn, you're right, I know what I'm up against and that means i will probably have to up my adderall dosage for a week then come back down to 50 daily. I mean it's either that or I die in speed hell. That's my choice now; psychosis, permanent brain damage, institutionalization, and death, or go through the hell again, and move the fuck on.
 
Cocaine's pharmacodynamic is different than that of amphetamine's, so I'm not quite sure how they would be cross-tolerant.

If I'm wrong, please feel free to correct me; however, I know that their pharmacodynamics differ.

~ vaya
 
Soap MacTavish said:
hm, well, it appears that MDPV is strong enough to totally overpower my adderall comedown completely and erase it. It's definitely no replacement for amps though, not a very friendly substance.
Click to expand...
Soap old buddy, the way you abuse your addies the thought of you with a few grams of MDPV worries me.
 
400px-DAT1regulation.jpg


Ampethamine reverses the flow of serotonin/dopamine/norepinephrine transporters, thus causing a large release of all 3 neurotransmitters into their synapse and also indirectly inhibiting reuptake.

Cocaine is a potent serotonin/dopamine/norepinephrine reuptake inhibitor.
 
^After a huge mdpv binge (stayed awake for 7 days) i found out that my tolerance to regular amphetamine had skyrocketed in a way that's not describable. The (large) amounts i normally take to get spun had almost no effect on me. There's definate cross-tolerance between amps and peevee.
 
ro4eva said:
Ampethamine reverses the flow of serotonin/dopamine/norepinephrine transporters, thus causing a large release of all 3 neurotransmitters into their synapse and also indirectly inhibiting reuptake.
Click to expand...

This is what I'm confused about. Can you explain the indirect action of amphetamine on inhibiting reuptake of these neurotransmitters?

Thanks muchly!

~ vaya
 
Vaya said:
This is what I'm confused about. Can you explain the indirect action of amphetamine on inhibiting reuptake of these neurotransmitters?

Thanks muchly!

~ vaya
Click to expand...

Cocaine & friends inhibit the dopamine transporter from doing it's job.

Amphetamines cause the dopamine transporter to spit out dopamine and while it's doing this it obviosly cannot reuptake any dopamine because it's being too busy spitting it out.

This is how i understood it. Anyone correct me if i'm wrong.
 
^ Exactly correct. Think of a transporter as a door that is normally supposed to only open one way. Amphetamines make that door open the opposite way. And because its opening the other way, it's spitting out your dopamine/serotonin/norepinephrine reserves (into your synapses) and making you high.

Also, normally the transporter is used by your brain to reduce or balance excessive amounts of dopamine/serotonin/norepinephrine in your synapses.
 
Understood! Thanks, I just took a class in pharmacodynamics and we studied the differences between the actions of amphetamine and cocaine; I guess I didn't learn it as well as I thought. I appreciate the clarification from both of you.

~ vaya
 
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