(-)-methopholine is 3 times as active as codeine, racemic 4'-nitro derivative is the strongest from this group (it's all comparison in strength when injected s.c.). Actually, activity falls like this: NO2 > F > Cl > Br. Moving groups from position 4' also causes fall in activity. Drugs are also spasmolytics. Actually it's nothing interesting and desperates are better ending ingesting codeine (or might even get a bigger chance to get a pure grade chemical that can be shot i.m. instead of losing money in search for this - I can imagine, they're ridiculous, especially when it's not so hard to synthesize it).
Yeah, having doses for s.c. I'd say if 400mg codeine i.m. is alright, then (400mg/20)- cross tolerance is my 'educated guess'. I don't know if educated guesses are a good idea in this field of science anyway.
Anyone else before i toss this batch??



