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[Mega]Synthetic Cannabinoid Discussion

Here's another new one that just showed up on the scene, (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone a.k.a. RCS-4.

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(image is my own because I couldn't find one online without a price plastered over it)

I like that there's no naphthalene ring, and I hope it turns out to be a good one for that reason if nothing else. On the other hand, though, this appears to have hit the market before the literature, so there's nothing to go by other than comparing it to other cannabinoids that are already out there and waiting for the trip reports to start coming in. Any thoughts?
 
Well it sounds rather promising due to it's less threatening composition, but I tend to stay away until a vendor I trust has it, as well as a few BL'ers or mods have posted trip reports or comparisons.

I'm being enough of a guinea-pig already :)
 
Can't blame you there. Personally, I'd have some on the way already if finances allowed, but as it is I'll be waiting till the end of the month to order some and give a report. It's basically JWH-250 without the extra carbon between the ketone and phenyl ring, and with the methoxy moved from position 2 to 4. I just wish we knew more about how these synthetics actually fit into the cannabinoid receptors in order to make a better guess at what that will change, but then again, I suppose all these new variations that keep coming out could make that sort of thing easier to study. It'll also be interesting to see how quickly this one metabolizes - a longer-lasting 250 would be pretty much perfect IMO.
 
Beerios said:
It'll also be interesting to see how quickly this one metabolizes - a longer-lasting 250 would be pretty much perfect IMO.
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Yeah - that was what mainly piqued my curiosity as well. I wish I was knowledge enough about these compounds to make an educated guess - but alas, I am not ADD material.
 
Okay so a quick update on the JWH-250 v -018. This post is being typed up over the course of 30 minutes.

~5 minutes ago I smoked roughly 15-20mg on a snowcapped cig and vape the powder that way (no filter). This is typically a smaller dose than I usually would use with -018.

Immediately I noticed a few differences:

-On -018, I notice slight jaw tension on the come up, a bit reminiscent of the stimulant-like feelings of coming up on acid. On -250, however, I noticed no such thing. I also note that this seems to be more in line with a sativa type head high minus any CBD/N presence, unlike -018 which I would say provides a good middle ground of mind-fuck and couch-lock. So, in essence, it provides a bit of a "high clarity", whereas I feel -018 provides both sativa and Indica properties.

-250 dosage is -very- similar to -018, I would say -250 is a bit more potent. It provided a relaxing and clear-headed high as other users have reported. On -250, my eyes instantly felt glazed over, instead of red and half-closed.

~10 minutes in, now what I would consider the peak of -250 when smoked/vaped. Steady climb to the peak as well, bit of a rush at the start but not so much after the first 1 minute.

-In comparison to -018, which I would say has an extremely strong "rush"-like come up when smoked, and a 30 minute peak.

~20 minutes, noticing a come down already. Desire to redose via smoking method is rather strong, but I'd rather vape it off a bowl this time instead of a cig.

-Again, in comparison to -018, I would consider this even more short-lived, which is difficult to imagine.

All in all, I like -250, but I prefer -018. A mix of the two would be interesting, and likely what I will do next time around.
 
chainer3k said:
A mix of the two would be interesting, and likely what I will do next time around.
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I've tried a mix of the 250 and 018 and it was great. Highly recommended. I've got a gram of RCS-4 coming to me, i'll let y'all know with a trip report once I get it.
 
chainer3k said:
It shouldn't. It should go clear like a small puddle of transparent goop, then evaporate. Color after evaporation likely means you've got a cut product.
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Well, solved the problem of the dirty pipe, bloody stem snapped off in my hand. I was completely sober at the time. I haven't had it long wonder if there's warranties for these things.

I think either my 081 or 250 was pure, that was when I was still using foil, it turned into a liquid bubble that got smaller and then popped and was no more but mist.
 
This seems to be an old thread, but its the closest thing I came up to in a search. Hopefully someone has a pretty good answer for me.

I purchased 1g of JWH-018 online, but I don't think I would smoke it off of foil. And making "spice" seems too much work. My thought was to disolve 100mg in 10ml ethanol (50%/100 Proof) then dilute the solution in 990ml of distilled water, making a mixture of 1mg per 10ml. Then dosing 10ml at a time to test the effects.

Will it disolve in 50% ethanol? And will it dilute properly in the distilled water?

I do know the 'suggested doses' floating around. And I know how to smoke, or make spice. I would much rather consume it orally 1mg at a time. I only divised THIS plan after reading JWH-018 can cause severe head-aches when taken with alcohol, this small amount of alcohol should have no adverse effect...right? This is my first experience with any RC and would like it to be a good one. Any advice on this method would be greatly appreciated.
 
merged into synthetic discussion mega thread.

Doc - that part about the alcohol, never heard that before. Some people just get headaches from it, others do not. Also, are you talking about consuming ethanol? JWH won't dissolve in 50% ethanol ime very well, not as near as well as in 100% acetone.
 
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Yes I was talking about disolving it in liquor, and diluting the substance in water. I believe the MSDS I read on it said it was soluble up to 25mg per 1ml of ethanol. Which with 50% ethanol and less than half the ratio of 25:1 (mine 10:1) I thought it would work adequate at best. Really I am fairly positive it will disolve eventually in the right ratio, just don't want to mask the effects of the 018 with alcohol. I am really more worried that diluting the mix in water will result in an uneven mixture, or cause the 018 to seperate from (drop out of) the liquid. Disolving it in acetone or isopropyl would leave me with a substance that would have to be evaporated and smoked, even if it were diluted 100:1 I still wouldn't feel comfortable consuming either. I am really trying to avoid smoking it as much as possible or even consuming it with food for that matter.
Its supposed to be a controlled test to determine the effects on myself (a non THC or any other illicit substance user for several years) and a friend who uses marijuana daily and other substances on occasion. We already know the potency of "spice" blends and the effects of smoking. While the effects may be only slightly different if at all, it would be a good experiment to see the actual dosage of oral consumption between the polar differences. I was guessing myself 2-4mg and he ~10+mg.
Thanks for the reply. Its good to hear someone say "in my experince" instead of "in my opinon." So will it disolve at all or do I just need a stronger ethanol (liquor) I can easily get 75.5% (151 rum) but everclear or absolute alcohol would require a 4 hour drive.
 
151 probably won't dissolve it very well, but I've never tried. I do know it has not dissolved in any shot of vodka I've ever tried. Everclear worked, however.

Oral consumption of JWH is going to be ~ double what you would normally smoke. If you have a 2mg tolerance, I'd eat 4mg and probably redose in an hour or so. For example, I vape 20mg, so I drink 40mg in each shot. If I redose 2 40mg shots, I get realllllyyy nice for ~5 hours.

This is assuming we are talking oral JWH-018. I haven't had the same luck with 250 thus far.

I assume the issue is you don't have a MG scale? If you do, you don't need to dissolve this in any solvent to take orally, you can just put it on a shot of juice if you want. IME it takes 1-2 hours for me, but I've seen it take 2+ hours for some people.
 
Bupe said:
JWH-250 IS NOT SAFE AND POTENTIALLY VERY DANGEROUS

So I don't have herpes although that might be better but these dotted sore clusters on the surface of my skin have to be from JWH-250. I looked at my oil vape pipe and I was shocked to see the residue had turned dark and divided into splotches EXACTLY like the ones on my skin. I'm not sure what to do. I really don't want to explain this to a doctor but it looks like I might to be safer.
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http://www.bluelight.ru/vb/showthread.php?t=519882
 
Never heard of anything even remotely close to that... you also binged on meph. My JWH-250 does not turn dark but evaporates evenly, leaving a slightly sticky clear film on the bowl and plant material below it.
 
Started smoking cannabis regularly again and I have to say that I remember why I prefer it to JWH. Don't get me wrong, I still like JWH but I think I just associate Cannabis with too much nostalgia and that adds to the euphoric feelings and whatnot...
 
Update jwh018 still gives me headaches just behind the eyes and lower forehead... migraine like but not quite as bad, everytime I use it. That one is not for me.

073 doesn't seem to do that though... that's the only other jwh I tried.
 
My experiences with 073 didn't really seem to be that great. Perhaps I didn't smoke enough, but the high just made me tired. Actually, when I was high on a predominately 018 mix, we made a 073 mix and it seemed to kill our 'fun' 018 high.
The 018 was good though, although the second night in a row smoking it wasn't as good as the first, but that might have been due to who I was smoking it with, or maybe I built a slight tolerance. I don't know.
It's been a couple nights since and I'm feeling a little disoriented and not fully connected for the past couple days. Anyone have this with the JWHs?
 
So for an update. The JWH-018 disolved in the 10ml 151 proof rum. Not easily though. Had to add heat. I just nuked it for about 4 seconds. The JWH immediately melted to the bottom of the cylinder. Most of it disolved after about 15 minutes of stirring, but I still lost a lot of the product stuck to the sides and bottom. If I were to do it again I would definetly put the cylinder with just alcohol on heat and keep it around 150F while I slowly added the JWH. And possibly use everclear next time. I then added the mix to a bottle and filled with water to 500ml. I'm assuming I lost about half of the JWH (50mg) due to melting and evaporation. even in the event it was less than that we still plan to dose 10ml at a time and call it 1mg, though it could be as high as 1.5 or even lower than 1. The mixture itself looks like water with sodium bicarbonate (baking soda.) So I plan to leave it to set overnight and make sure it doesn't separate.
 
Some good ideas. Just be very careful with everclear around sparks and/or open flames as the liquid itself is flammable and its vapors mixed with air in the correct ratio could potentially be explosive.
 
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