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Stimulants Meth dopamine spike=WOW

^ Not too sure about that. It could be the sudden release of dopamine and serotonin from the MDMA and meth - 5 pills is quite a lot!
 
^
Usually I just take 1.5 or 2(in one dose, always good pills) and stick with that, space it out weeks nowdays and months this time. But I had as many pills as I wanted for about nothing and liked these a lot, oops(this was 3, then later one more orally, one snorted, also something I don't do but I was in an odd state).

The zaps didn't start till the next day if I remember right, it almost felt like they gave me energy! A few people on here mentioned it too(also with meth and mdma if I remember right).
 
There truely is no comparison between smoking/shooting meth, and orally taking any form of mdma [or what you think might be mdma] and dexamphetamine, or any other formulation of phet., from my experience anyway.. although even smoking meth isnt what it used to be..
 
^
What? where did that come up? We weren't talking about combos of mdma and dex that would compare to meth. And I'm thinking that "smoking meth isn't what it used to be" for you just means you have a tolerance or something, because I think meth is one of the few drugs that's gotten better and more common in the past few years(could be wrong though).
 
Sweet P said:
The methyl group in methamphetamine makes it a much more potent drug than regular dextro-amphetamines, and also a lot more neuro/cardiotoxic. I believe it does cause a greater release of dopamine than dextro-amphetamines, hence its neurotoxicity, and it also causes a large release of serotonin and norepinephrine.
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I don't think that is true, it is better on the body, more harmful on the brain, no?
 
i imagine an equivalent dose of meth compared to amp would have a lesser increase in heart rate. though its potency also means you can get more effect and quicker and for much longer. i think it makes sense to say meth could be a little easier on the cardio system at an equivalent high and meth could do also little more damage in the brain, assuming the user isn't surpassing the high he can get from amp using lots of meth. i haven't seen the numbers though

the thing about the methyl group is it not only makes it more toxic but also more potent. taking that into account i'm not sure if it's more toxic at an equiv dose. (i'm assuming it makes it more fat soluble.. also would lead to quicker onset)
 
i haven't looked much into stims cuz they aren't my thing. just sayin, could be wrong (first time for everything)

it's an educated guess based on a horrible memory :P
 
^ Haha, it's ok. I did a bit of reading, and what you and Depressicaa said seems to be right. :)
 
When I was younger (back in the 70's), I would abuse the heck out of street meth. I cleaned up for about 20 years, but not to long ago I was diagnosed with ADD. Well duh, in hindsight. Anywho, after that long hiatus from street meth, I was scripted 10mg Dex IR, 30 mg twice daily.

I managed to keep to that for about a week. Within a couple of weeks I was eating upwards of 600-800 mg a day. Tolerance is quick for folks like me as addiction is life-long regardless of my usage patterns. God bless my wife who now acts as my pharmacists and gives me my daily doses.

Point: If you have an adictive personality, meth or amp are not drugs to "play" with unless you are willing to accept the consequences. Of course your milage may vary. :)
 
Ugly- you say you snort yours. Have you tried smoking? It's a very different high imo. More heady euphoria less tweaky body effects. No need to buy a piece, just put a small shard on foil, melt it, let it crystalize again, light up and inhale through a straw. Just like chasing the H dragon.

I don't want to encourage abuse, but if you're into it anyway, might as well experience all it has to offer.
 
I had no idea that it could be chased like a dragon. I never pictured it like that because when I smoke tar it comes in a sticky piece thats easy to follow. So just put a pinch of power on the foil and blow it like tar? Are you sure it won't just melt all over?
 
^
Good advice.

If it's too fine a powder it doesn't work as well. Works better with shards- even if they're really small shards that'll work. Once you put the flame to it it'll melt to the foil making it easier to smoke.
 
ugly said:
I hate my fucking sweaty palms. It is the WORST. Does anybody else get the sweaty palms from the meth? Is there something I can do for it besides hold ice cubes?
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http://en.wikipedia.org/wiki/Hyperhidrosis

There's a few basic things you can do but it's not as effective for everyone I guess. You can see a doctor if this persists beyond being on meth, but I am thinking you could try mediating the increased blood pressure by taking l-arginine.

Sweet P said:
Meth does feel great at first, but the greatness doesn't last. I've had a 3 year chronic meth addiction (smoking and IV'ing) and now I honestly feel that it's the most evil drug around. I remember times when I was actually crying while smoking from the pipe, cos I had absolutely no control over the drug. And then there were the psychoses. Anyway, I don't mean to be a buzz-kill. Just thought I'd add my two cents from someone who's "been there". Be careful.
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Thank you for adding your experience P, I think it's an important message that people should consider.

I am really careful when I take amphetamines, and I know that it's very easy to get carried away with them, so I make sure to be prepared for days without it while still feeling all right.

I think what you described can be a stage where people find inescapable tolerance to their DOC, and can be applicable to most drugs of abuse (heroin, cocaine, meth, and so on...).

I'm not a long term user of meth but within a week of using it (IV), the effects are diminished drastically, to the point where it's still desirable to use it but you're getting only 25% or less of the effects you would if you were to give it 3-5 days (or longer) and do it again.

Eventually I had to give it a break, it was almost adversive to continue using it after a while. Then again I am not used to being on amphetamine *constantly* which is easy to achieve with 1 dose of methamphetamine per day (even IV).

canucka said:
There truely is no comparison between smoking/shooting meth, and orally taking any form of mdma [or what you think might be mdma] and dexamphetamine, or any other formulation of phet., from my experience anyway.. although even smoking meth isnt what it used to be..
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IV MDA won by far in my book.
 
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fryingsquirrel said:
You'll want to bend the foil in kind of a V and let it run down the groove.
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I have an order in. I don't know when I will get it. Probably tomorrow which is fine because a few days inbetween hits helps me feel the hits better. Anyways I am going to give this a try. I don't want to get addicted to it. I never got as high from smoking tar as I did from snorting oxy, so this might end being the same kind of situation. Or I might like meth better on foil. I'll let you know.
 
Those data on dopaminergic spiking are of saturation levels for in vitro cultures (compared to what's typical under normal conditions). Generalization to how such substances work in vivo at recreational doses is less clear, particularly when such substances aren't administered directly to the brain, nor does dopamine-mediated transmission remain constant under differing behavioral conditions.

ebola
 
Clearhead said:
Thanks for the info guys:)

"have you done meth?" crystal meth? NO WAY, never have never will, i'v seen to many in state psych units and prison to 'try it just once' as far as i'm concerned crystal would turn the Pope into a satanist and the people who make the crap and sell it to kids should be shot.

I have a very sever case of ADD (according to top psychiatrists) and it rules my life. I was treated with medical Desoxyn SR tabs and they were the most satisfactory medicine i'v taken and slowed down the whirlwind in my head, alas they are no longer made as the cost to the company became uneconomical.

Ritalin at 60-80mgs 3-4x daily put me to sleep, and had avery short term of effectiveness.
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I also have a script for OV Desoxyns. You say you took 15 mg 3x or more a day? WTF!? I take two 5mgs and feel pretty euphoric. But I also only take it 2 times a week. And BTW Desoxyn is more recreational then Street, mainly cause of it's purity.
 
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