For me it depends on how engaging it is, i usually dont.. if ever play video games while tripping.. but i have in the past out of curiosity, and like movies.. if i become heavily engaged it can really put a completley different spin on the trip, a feeling of actually been submersed within the game..
Where the notion of reality as i understand it cease's to exist and the only thing happening right now, is this video game. I've had this experience happen a few times with movies where i was 'put' within the movie and i was no longer an observer of actors but a person been spoken to by the actors
Takes the idea of RP'ing to the extreme haha.