I've done both numerous times... It really depends what you are hoping to gain and how accustomed to the psychedelic experience you are. If you're pretty new, 4-aco-dmt is very forgiving. 2c-e is a cold, analytical teacher that will eat you up and spit you out without w warring at the slightest sign of disrespect.
They are both very rewarding experiences... But 2ce definitely requires a bigger commitment.
Good luck on your adventures. :D

My advice: do your research...