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5-HTP with MDMA?

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roganmaster

Bluelighter
Joined
Mar 2, 2010
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Anybody ever take 5-HTP at the same time as taking their MDMA? The 5-HTP FAQ doesn't really cover this so I was wondering if it would help a roll, hinder it, or make it dangerous. I was thinking about doing 100mg 5-HTP along with a roll of about 150mg MDMA.
 
Most of the things I've read say it didn't make much difference, but there are so many different reports so it's hard to tell. Depends on the person I guess
 
Theres so many conflicting reports, alot say it makes mdma less intense, some say it makes it last longer, one of the Q&A's about it on Erowid says it makes it stronger. I took mdma the other night after taking probably 600mg of 5htp throughout the entire day and I still rolled so I dunno that makes me not belive that it ruins it. I actually felt it more than the last time i took one of the same pills so i dunno
 
roganmaster said:
Anybody ever take 5-HTP at the same time as taking their MDMA? The 5-HTP FAQ doesn't really cover this so I was wondering if it would help a roll, hinder it, or make it dangerous. I was thinking about doing 100mg 5-HTP along with a roll of about 150mg MDMA.
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Serotonin releasing agent + more serotonin at the same time = possibly getting your good ol' friend serotonin syndrome.
 
first you have to ask how much 5htp is actually making it to your brain and transferring through the blood brain barrier? from what i heard much of it is metabolized in your abdomen and only a small percentage actually makes it to your brain.

i havent tried taking it with my roll but ive tired it twice, both times taking 100mg as i was peaking/coming down. both times i experienced waves of euphoria but i cant say if it was the 5htp or the roll it self. otherwise i didnt feel like it affected me in any other way.
 
I was thinking of taking about 50-100mg 5-HTP along with the molly. My guess is that seratonin syndrome is unlikely at such a low dose?
 
Waste of 5-HTP and potentially very dangerous to your health, it's a stupid idea.

Your not going to get "high" off the htp nor will it do anything to boost a roll.
 
smellytim said:
i dont want to say it definitely wont cause serotonin syndrome, but i cannot imagine it causing it.ive taken it about 5 minutes before a roll before and i definitely didnt get serotonin syndrome.

will however probably lessen the roll, and this is me theorizing but since it works on the same receptors it would probably take those receptors away from the mdma?
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MDMA doesn't bind to serotonin receptors very well (it has some weak action at 5-HT1 and 5-HT2 receptors, MDA has a bit more affinity), it binds to the serotonin transporter, which causes it to release serotonin, which binds to serotonin receptors. Taking 5-HTP increases your serotonin levels, and the new serotonin either binds to serotonin receptors, or is taken up by the serotonin transporter, which got put in reverse by the MDMA so it won't get taken up. Too much serotonin activity is also known as the lovely serotonin syndrome.

happyland said:
first you have to ask how much 5htp is actually making it to your brain and transferring through the blood brain barrier? from what i heard much of it is metabolized in your abdomen and only a small percentage actually makes it to your brain.
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Green tea or green tea extract (EGCG and EGC) inhibit the dopa decarboxylase enzyme responsible for the conversion of 5-HTP into serotonin in the gut.
 
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