Wellbutrin SR = Buzz Kill?

[punkftl]

i take 200mg. Wellbutrin Sr. twice daily along with 140mg Methadone, dexedrine and xanax.

i take my methadone at 9am and noticed that if i take my wellbutrin BEFORE dosing, the effects of the methadone are lessened..but if i dose at 9am and take wellbutrin at 12pm, i feel more of the effect...am i just imagining this or does liver enzymes have a part in this?

 

[Violenza666]

maybe that's why my evil mother had me on such a high dose of wellbutrin as a child..

 

[ergert]

I am not a doctor or anything, but doesnt the combination of dexedrine and xanax counteract each other? Why would you take a stimulant and at the same time take a benzo? Maybe there is a reason, but I was just curious.

 

[Psychedelic Jay]

I am not a doctor or anything, but doesnt the combination of dexedrine and xanax counteract each other? Why would you take a stimulant and at the same time take a benzo? Maybe there is a reason, but I was just curious.

Xanax and dexidrine do not counter act each other.

Xanax is not a strong enough downer by itself to kill a dexamphetamine high. It will however, take the edginess off of the high.

 

[Jamshyd]

What fucking idiot of a doctor is putting you on all these?

Dexedrine + Xanax is a great way to get a taste of psychosis. No, they don't counteract each other - they make each other more psychologically dangerous.

Add burpropion to that at such a high dose and you guarantee yourself psychosis AND seizures.

p.s. And even when this combo is at its best (which it would never be), the wellbutrin and amphetamine weaken each other (depending on which you take first), similar in a way that cocaine and MDMA weaken each other if coke is taken first. But even that would not limit the seizure potential.

 

[Psychedelic Jay]

What fucking idiot of a doctor is putting you on all these?

Dexedrine + Xanax is a great way to get a taste of psychosis. No, they don't counteract each other - they make each other more psychologically dangerous.

Add burpropion to that at such a high dose and you guarantee yourself psychosis AND seizures.

p.s. And even when this combo is at its best (which it would never be), the wellbutrin and amphetamine weaken each other (depending on which you take first), similar in a way that cocaine and MDMA weaken each other if coke is taken first. But even that would not limit the seizure potential.

Disinhibition is not psychosis. That's about all you are gonna get out of that, on top of the euphoria. They are prescribed with each other for the same reason everyone who likes to mix them take them together. Benzos calm the mania(not always, especially if you are bi-polar) and jitters of amphetamines.

Topic: I would look on Drugs.com at this combo between Welbutrin and Dexedrine.

 

[punkftl]

I am not a doctor or anything, but doesnt the combination of dexedrine and xanax counteract each other? Why would you take a stimulant and at the same time take a benzo? Maybe there is a reason, but I was just curious.

not really because xanax affects the neurotransmitter GABA, and dexedrine affects the neurotransmitters dopamine, norepinephrine and to a lesser extent, serotonin.

some people will take adderall with xanax so they get the high/buzz from the adderall, while the xanax prevents any tremors or anxiety the amphetamine might cause.

now i take xanax for sleep and have been since 2000, 5 years before i started taking the dexedrine.
i take 3 10mg. tabs of immediate release dexedrine around noon and then i take my xanax at bedtime.
dexedrine is less likely to cause anxiety and tremors because it affects dopamine more than it affects norepinephrine. and because i have ADD, the dexedrine actually calms me down...well it calms my racing thoughts down so i am able to complete a task without getting distracted and finish a task before going onto another.
it also helps me drive....without the dexedrine, i am looking for a dopamine rush and driving fast always helps, but the bad part is the parking tickets. i have had at least 3 speeding tickets, but because my lawyer tells the judge i have ADD and forgot to take my meds, it gets thrown out of court.

dexedrine doesn't affect my sleeping patterns at all either...i have always had sleeping problems since i was a teen and xanax is the only thing that works that doesn't make me more depressed...such as Valium, Ristoril, Ambien, etc.

 

[punkftl]

What fucking idiot of a doctor is putting you on all these?

Dexedrine + Xanax is a great way to get a taste of psychosis. No, they don't counteract each other - they make each other more psychologically dangerous.

Add burpropion to that at such a high dose and you guarantee yourself psychosis AND seizures.

p.s. And even when this combo is at its best (which it would never be), the wellbutrin and amphetamine weaken each other (depending on which you take first), similar in a way that cocaine and MDMA weaken each other if coke is taken first. But even that would not limit the seizure potential.

because i need it...DUH!!! i have NEVER had a problem with psychosis. where do you get your information from? sorry to tell you this but you, not my doctor, is a f*cking idiot.
people who have ADD/ADHD and are prescribed stimulants are usually prescribed a benzo at night to help them sleep. this is common.
and my depression/ADD is the type where i have severe fatigue.
and since i have been on this combination for MANY years with no side effects, it's highly unlikely that psychosis and seizures would start now.
now is see why we have such a problem with education here in america

 

[punkftl]

thanks Psychedelic Jay, will have to check out drugs.com, i appreciate it

 

[Jamshyd]

because i need it...DUH!!!

NO ONE - NO ONE, needs stimulants. I don't care if you have ADHD. NO ONE needs stims in order to live.

i have NEVER had a problem with psychosis.

Because you're just starting out.

where do you get your information from?

- Personal experience (I was RXed dex and bromazepam).
- Scientific reseatch.
- Being on BL for so long and seeing a very very clear pattern for users of these drugs.
- Books
- University training.

sorry to tell you this but you, not my doctor, is a f*cking idiot.
people who have ADD/ADHD and are prescribed stimulants are usually prescribed a benzo at night to help them sleep. this is common.
and my depression/ADD is the type where i have severe fatigue.

I am depressed too, and have fibromiyalgia too. Benzos are indicated for short term use no matter what you use them for. And amphetamines? Well they aren't exactly safe long-term.

and since i have been on this combination for MANY years with no side effects, it's highly unlikely that psychosis and seizures would start now.
now is see why we have such a problem with education here in america

I am not in America, but apparently you are.

You've been on this combo for many years?

Then why are you asking us?

To your credit, methadone seems to have anti-psychotic activity. But this is still a very, very stupid combo.

I will bet that you are the self-appointed "doctor", or that you're playing with 2 doctors and not telling one what the other knows.

Enjoy your seizures and your psychosis.

Oh, and possible heart-failure, too. Bupropion is contraindicated for anything adrenergic, even sudafed.

 

[Jamshyd]

Disinhibition is not psychosis..

And what does disinhibition do? It makes you take more drugs. And what happens when you take too much of both? You black out since xanax cannot put you to sleep. What happens when you black out? You take more drugs.

Repeat and rinse.

 

[punkftl]

NO ONE - NO ONE, needs stimulants. I don't care if you have ADHD. NO ONE needs stims in order to live.



Because you're just starting out.


- Personal experience (I was RXed dex and bromazepam).
- Scientific reseatch.
- Being on BL for so long and seeing a very very clear pattern for users of these drugs.
- Books
- University training.


I am depressed too, and have fibromiyalgia too. Benzos are indicated for short term use no matter what you use them for. And amphetamines? Well they aren't exactly safe long-term.


I am not in America, but apparently you are.

You've been on this combo for many years?

Then why are you asking us?

To your credit, methadone seems to have anti-psychotic activity. But this is still a very, very stupid combo.

I will bet that you are the self-appointed "doctor", or that you're playing with 2 doctors and not telling one what the other knows.

Enjoy your seizures and your psychosis.

Oh, and possible heart-failure, too. Bupropion is contraindicated for anything adrenergic, even sudafed.

Nobody NEEDS stimulants to live, but people with ADD/ADHD produce low levels of dopamine..this has been scientifically proven by SPECT scans. and is accepted in the medical community.
it is also proven that people with ADD/ADHD are more likely that those who do not have it act out, and engage in dangerous activities.
using stimulants in these situations have shown to reduce or completely eliminate these problems.

also i have been on this combo for well over 8 years.
and personally, i do not experience any disinhibition. that is seen in people who use crystal meth, coke and crack...shows how much u know

 

[paranoid android]

Thats a rather high dose of wellbutrin especially taking it with amphetamines. Your lucky if you don't get drug induced mania.

As for the wellbutrin killing the buzz of the methadone i don't see why it would unless it has something to do with wellbutrins cyp2d6 inhibition and i don't think methadone is metabolized by that enzyme. But i could be wrong since i don't know much about done as it's one opioid ive never been on.

I take 150mg wellbutrin SR twice a day with morphine and clonazepam and it isint a buzz kill at all for me.

I occasionally use dextroamphetamine and coke/crack for fun and when i do i always make sure and skip my dose of wellbutrin that day. Ive never had a problem with stimulants causing disinhibition except for them making me more horny that is lol. Also i take lamotrigine and risperidone so i skip the risperidone as well or i won't get anything off the stimulants.

It's weird that im bipolar and although serotonic anti-depressants make me manic as fuck dextroamphetamine does not do it at all.

 

[Jamshyd]

Nobody NEEDS stimulants to live, but people with ADD/ADHD produce low levels of dopamine..this has been scientifically proven by SPECT scans. and is accepted in the medical community.

a. I want a reference for these scientific findings.

b. Can you tell me why taking a high dose of Levodopa not only does nothing to ADD, but also causes something like parkinsons?

it is also proven that people with ADD/ADHD are more likely that those who do not have it act out, and engage in dangerous activities.
using stimulants in these situations have shown to reduce or completely eliminate these problems.

Again, citation for that claim?

also i have been on this combo for well over 8 years.
and personally, i do not experience any disinhibition. that is seen in people who use crystal meth, coke and crack...shows how much u know

Of course! All drug users can fuck up. But you? You're invincible.

No doctor in his right mind would prescribe xanax with methadone except in extreme cases and in tiny doses. They are contraindicated on their bottles.

No doctor in his right mind would prescribe dexedrine with welbutrin in any circumstance. They're contraindicated on their bottles as well.

And most certainly no doctor would prescribe all of these together.

Besides, if you take Methadone legally, chances are you're an ex-addict. No doctor in his right mind would prescribe combos of addictive drugs to ex-addicts.

If you know so much, then why do you ask here? Obviously, "u" know more than all of us. So go swallow all these pills and show us whose boss!

 

[punkftl]

find the references for yourself! i have already done my own research online and read all i need to know..
i came on here to ask a simple question...not to waste my time getting judged by some ignorant

 

[Jamshyd]

"Find the references yourself" is what ignorants say when asked for them.

---

I just can't stand it when people post a question and then, not satisfied with the replies they get, actually go on to attack those who replied. If you knew so much, why do you ask? BL is a Harm Reduction forum. We don't care if you're getting a good buzz or not. What we're here to do is tell you what's not safe. And what you are doing is not safe, period.

I guess you wanted something more along the lines of "nah man, just crush the wellbutrin and snort it, it'll get you so buzzed maen!!!"

Now, go on with your "buzz kill".

 

[trocious]

a. I want a reference for these scientific findings.


No doctor in his right mind would prescribe xanax with methadone except in extreme cases and in tiny doses. They are contraindicated on their bottles.

No doctor in his right mind would prescribe dexedrine with welbutrin in any circumstance. They're contraindicated on their bottles as well.

And most certainly no doctor would prescribe all of these together.
!

So unfortunately, I think a lot of doctors ignore those contraindications. I was prescribed welbutrin for some time to treat depression, which it worked wonderfully. I then saw another doctor (a psychiatrist) who prescribed me both welbutrin and low dose ritalin, then vyvanse.

As to the OP, I do believe the welbutrin can cause some diminished effects from both the stimulants and .... everything else.

I know from personal experience that taking welbutrin BEFORE the stimulant will greatly reduce its efficacy. However, if I take it AFTER the stimulant, it seems to put a "cap" on it while also extending its effects.

For an optimal balance of effects and side effects, I try to take marginal amounts of the welbutrin if I want to experience more of an amphetamine buzz, or take the amphetamine before the welbutrin.

Overall, if I want to feel more than a slight tingle, I need to either take <100mg of welbutrin before other drugs, or take <200mg of welbutrin a few hours after taking stimulants.

I can't help you too much on the methadone/xanax, although the one time I took any opiate with welbutrin it was on an empty stomach and I just got sick without many positive effects.

 

[Jamshyd]

^ Well yes. If the OP had bothered read the advice I had given him in my 1st post, he'd have realized I was saying what you're saying.

Welbutrin before dex WILL deminish the effects of the latter.

Cocaine before MDMA WILL demenish the effects of the latter.

Ritalin before meth WILL deminish the effects of the latter.

Why? Because reuptake inhibitors "hijack" the same transporters to do their job which also release the transmitters, and therefore the releaser's effects would be deminished.

HOWEVER, even though wellbutrin diminishes the buzz from the dex, it will still pose extreme danger of heart failure as well as seizures.

 

[seep]

I am not a doctor or anything, but doesnt the combination of dexedrine and xanax counteract each other? Why would you take a stimulant and at the same time take a benzo? Maybe there is a reason, but I was just curious.

I can vouch for this combo. It's not healthy living, but I take it every day. Amp alone makes me too jittery and sends me into spontaneous crying spells and makes me talk to myself uncontrollably. Benzo alone makes me unable to work and I'm a full time student and clinical researcher.

 

[seep]

NO ONE - NO ONE, needs stimulants. I don't care if you have ADHD. NO ONE needs stims in order to live.

qft

I'd make the exception, though, of a middle aged man using coke to pick up younger women.