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Harmala (err Syrian Rue Extract)/MAOIs to potentiate RCs

N

-neptune-

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Jul 21, 2008
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Hey all, just recently acquired some Syrian Rue Extract and was wondering if this would be safe to use to potentiate RC's, like 4-aco-dipt, which I also have a rather limited supply of. my 4-aco-dipt is dosed at at 20mgs, but I have a feeling that I will want to experience it at a higher dose range, but limited supply has me seeking ways to enhance what I have...

Has any one had much experience potentiating RC's (beyond DMT and DPT) with MAO Inhibitors? How many mg of Harmala should I use? the bottle says one dropper full is the equivalent of 500mg Harmala. Also, is Harmala a very potent MAOI? the herbal apothecary that I got it from had no information or contraindications on it, which made me rather concerned about either they don't know shit about it, or they aren't severe side effects if no dietary restrictions are taken...Any light shed on this would be greatly appreciated, sorry if there's already a thread on this.
 
There are a few reports on erowid about people taking random rc's with penganum harmala, but most didn't turn out well. Not recommended. Maybe someone with firsthand experience on the issue will chime in. I am not willing to be a guinea pig when maoi's are involved...
 
i only have experience combining harmala with psilocybes, which is a fairly safe combination.

while it may be easy to jump from 4-ho-dmt to 4-ho-dipt and consider them similar enough to call it safe, there is the possibility of widely different action especially in different individuals. consider the change from MDA to MDMA -- the former acts more as a traditional agonist on the 5HT system, while the latter causes the reuptake of 5HT to be reversed. combination of an MAOI with the former may be uncomfortable, yet deadly with the latter.

i would strongly advise against combining extremely powerful drugs like harmala with research chemicals. in addition, the comparison of DMT to DIPT gives us some information-- because DIPT is orally active, it appears to reach the brain before MAO is able to oxidise it. so it is entirely possible that 4-ho-dipt or 4-aco-dipt are normally excreted from the body after some other deactivation method, and the addition of harmala will not increase the serum level of 4-dipt.
 
it appears to reach the brain before MAO is able to oxidise it. so it is entirely possible that 4-ho-dipt or 4-aco-dipt are normally excreted from the body after some other deactivation method
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There are MAO enzymes in the brain, so I don't see why another method of metabolism need be considered....Most reports indicate increase in effects beyond placebo when combining many substances with a MAOi; to my knowledge the first deamination of indoles and phens occurrs via MAO a OR b. As egor said, being the guinea pig for this might not be such a great idea...
 
but you can potentiate things like mushrooms (4-ho-dmt) with Syrian Rue no problem correct?
 
What is the goal of potentiating things with MAOI's?

If the goal is to reach a higher level of tripping than would be possible, well, i can't say anything to that.

If the goal is to save money on drugs, the risk to your health and life is not worth the risk of throwing MAOIs around.
 
swilow said:
Yes, but why? Mushrooms are already orally active. I'd say leave the MAOi for non-orally active drugs, like DMT or DPT....
Click to expand...

Mushrooms and an MAOI are a completely different experience to mushrooms tho. It's far more like a ayahuasca trip (without the nausea) than a mushroom trip. It's massively more psychedelic.

Mushrooms and 300mg of moclobemide is something else.
 
Having both used moclobemide and syrian rue both with smaller amounts of the (DOC) psychedelic it does change the trip significantly.
 
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