I really like both defenses, and I think one of them will get a big stop in the second half of the game (given that it is a tight game)... I expect to see the Saints pressure Peyton a fair amount, and this should keep him out of rhythm enough to keep the Indy offense in check.
I think the winning team will be the one more pumped to win the game. I expect Drew Brees to get his team pumped for this game, and if they can keep the momentum from swinging way out of their favor, I expect them to win. If the Indy defense shuts down the Saints offense for the most part and captures the momentum, then I expect them to win.
I pick the Saints, though it is a tough pick and I certainly feel it is the underdog pick.