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1-Phenyl-2-methylaminobutan-1-one

N0 W4RN1NG said:
I would post this in BDD, but I feel like I'll get better answers here even if I have to revive this thread.

I hear many people saying that buphedrone is like amphetamine, minus the adrenergic 'push'.

I've heard that combos of ethcathinone, which is almost purely noradrenergic, and buphedrone have yielded very positive euphoric results. =D

I am receiving my buphedrone in a few days, and I can't help but wonder if anyone has tried combing it with ephedrine?

Ephedrine is also primarily noradrenergic, and it has a duration much closer to buphedrone's than ethcathinone does.

I was thinking about popping like 25mg of ephedrine and than busting out like a 30mg line of buphedrone 20 minutes later; it seems like this would be a really cheap and easy OTC way of turning buphedrone into a better stimulant.

I'll be sure to give it a go when I receive my shipment, as I have quite a few 25mg 'bronkaid' ephedrine tablets lying around, but I was wondering if anyone else thought this was a good idea?
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Ephedrine is a lousy drug - the ratio of PNS:CNS effects is lousy. Too much physical sideffects for too little mental high. I doubt for that reason that it would be impressive...
 
TheAzo said:
Ephedrine is a lousy drug - the ratio of PNS:CNS effects is lousy. Too much physical sideffects for too little mental high. I doubt for that reason that it would be impressive...
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Indeed, I agree that ephedrine by itself is a terrible drug to attempt to get high on. As you said, it is simply too hard on the peripheral nervous system without enough of a CNS boost.

However, buphedrone is remarkably mild on the PNS, so the addition of PNS effects by ephedrine probably wouldn't be too much more dangerous than taking ephedrine by itself; Apparently the addition of NE releasers\agonists side by side of buphedrone markedly enhances the experience - for this reason, I predict that taking a moderate dose of ephedrine(NE) with a moderate dose of buphedrone(DA), you would safely and efficiently achieve a more "amphetamine-ey" high.
 
I highly doubt it will be good combination. Look, at first buphedrone can have higher affinity to NE receptors but maybe act like an weak agonist, second reason - buphedrone by itsel will be metabolised to corresponding alcohol with structure very similar to ephedrine.
Why do you want more PNS stimulation? for having stronger comedown?
 
boohigh said:
I highly doubt it will be good combination. Look, at first buphedrone can have higher affinity to NE receptors but maybe act like an weak agonist, second reason - buphedrone by itsel will be metabolised to corresponding alcohol with structure very similar to ephedrine.
Why do you want more PNS stimulation? for having stronger comedown?
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I think the "reasoning" is that, since ethcat + buphedrone feels like amphetamine (or so others have said), and ethcat effects NE more than DA, the reason buphedrone itself is so lackluster must be that it has DA effects but lacks NE effects (a dubious claim if i've ever seen one >.> ).
If that claim is accepted, and ephedrine indeed acts mainly on NE (another thing i'm not sure about but which i thought i remembered hearing), even though it's pretty crappy, it might synergize with buphedrone.

I don't think this is a good idea either - but this is what i belive the intent of the combination is.

Actually if we accept the first claim (that buphedrone lacks NE effects and is less fun for that reason), and if buphedrone is metabolized into the alcohol ("buphedrine"?), and if the alcohol is metabolized more slowly (as is the case with meph), this might explain the reports (either here or in the BDD thread) that it gets more euphoric when you "binge" or repeatedly redose, if "buphedrine" has greater NE effects (like is the case for ephedrine vs methcat)

Yes, i am fully aware that I'm hypothesizing well beyond data here - i hope all the "if"s make that clear.
 
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Apparently the addition of NE releasers\agonists side by side of buphedrone markedly enhances the experience - for this reason, I predict that taking a moderate dose of ephedrine(NE) with a moderate dose of buphedrone(DA), you would safely and efficiently achieve a more "amphetamine-ey" high.
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Do we have many bioassays? I've seen mainly speculation on this. Also, as was said, ethcathinone might be a better bet than ephedrine.

But why would this approximate amp and not some DA/NERI, given that buphedrone is likely a reuptake inhibitor?

I highly doubt it will be good combination. Look, at first buphedrone can have higher affinity to NE receptors but maybe act like an weak agonist
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Possible, but on which bases would we suspect such? What in its structure suggests what about its activity?

, second reason - buphedrone by itsel will be metabolised to corresponding alcohol with structure very similar to ephedrine.
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right, but will an alpha-butyl in place of the alpha-methyl affect activity, particular that which is adrenergic?

Why do you want more PNS stimulation? for having stronger comedown?
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I read it as desire mainly for central NE fx. I believe this, and to a lesser extent peripheral activity, to contribute a lot to the stimulant body high and in this way euphoria. My experiments combining selegiline with stuff suggest so, but they also confirm that NE and/or adrenal agonism contribute greatly to the crash.
 
TheAzo said:
I think the "reasoning" is that, since ethcat + buphedrone feels like amphetamine (or so others have said), and ethcat effects NE more than DA, the reason buphedrone itself is so lackluster must be that it has DA effects but lacks NE effects (a dubious claim if i've ever seen one >.> ).
If that claim is accepted, and ephedrine indeed acts mainly on NE (another thing i'm not sure about but which i thought i remembered hearing), even though it's pretty crappy, it might synergize with buphedrone.

I don't think this is a good idea either - but this is what i belive the intent of the combination is.

Actually if we accept the first claim (that buphedrone lacks NE effects and is less fun for that reason), and if buphedrone is metabolized into the alcohol ("buphedrine"?), and if the alcohol is metabolized more slowly (as is the case with meph), this might explain the reports (either here or in the BDD thread) that it gets more euphoric when you "binge" or repeatedly redose, if "buphedrine" has greater NE effects (like is the case for ephedrine vs methcat)

Yes, i am fully aware that I'm hypothesizing well beyond data here - i hope all the "if"s make that clear.
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i was the fool who suggested who suggested combining buphedrone and ethcathinone for an amphetamine effect. i have tried both on their own and they feel like either side of the amphetamine coin, buphedrone feels clear, euphoric, physically so relaxed while ethcathinone feels very physically stimulating on your heart and rough on your stomach yet compulsive and wired. i haven't combined them as buphedrone has the satifying relaxation without the shitty effects of speed i dont miss. clearly though some do

buphedrone is great for sex (after every orgasm you cock feels more orgasmic-mayhem) and when it wears off you can sleep within a couple of hours.
 
Because the chemical name is alpha-methylamino-butyrophenone. That's where the butyl reference comes from. The "drone" suffix is most likely an attempt to cash in on the popularity of mephedrone...
 
I think that I get it. methcathinone = ephedrone (and you explained where the ethyl is in there)
add a 4-methyl and you have mephedrone. 4-fluoro, flephedrone, etc.

I see how buphedrone could arise linguistically if we either extend ephedrone or chop off a bit of mephedrone.

sorry...off-topc. :-)
 
pofacedhoe said:
i was the fool who suggested who suggested combining buphedrone and ethcathinone for an amphetamine effect. i have tried both on their own and they feel like either side of the amphetamine coin, buphedrone feels clear, euphoric, physically so relaxed while ethcathinone feels very physically stimulating on your heart and rough on your stomach yet compulsive and wired. i haven't combined them as buphedrone has the satifying relaxation without the shitty effects of speed i dont miss.
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So, has anyone actually tried them together yet? My ethcat should be here next week, and i'll give it a try, but i also think that ethcat will be the part of amphetamine that i don't like.

Re: the name, it was named more than half a century before anyone made mephedrone (or the XXXphedrones where xxx is the parasubstituant) 1920's wasn't it? and then forgotten about until some drug chemist was paging through the merck index or something looking for the word "stimulant" and cooked some up.
 
it will be the part of amphetamine you dont like IF the bit you dont like is pounding heart, tight stomach and muscle tension. dont forget is is euphoric in its own right though and it has pringle syndrome written all over my nostrils, comedown is bearable though
 
Where is the great leap in potency from methylone to butylone? There is none.
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You're talking about serotonogic compounds as they have a methylenedioxy group attached to the ring. If you look at shulgins data, alpha propyl abolishes activity, ehich isn't the case for stimulant effects (see MDPV)

Anyway, I've tried this at 25mg IM and it was a reasonable stimulant. Nothing overwhelmingly 'wow!' about it, but it did the job of stimulating and making enjoyable whatever it was I was doing. Lasted about 4 hours if I remember correctly. No particular jitteryness, just smooth (if somewhat understated) stimulation. Can't see how someone could take 100mg and report no activity


Re: the name, it was named more than half a century before anyone made mephedrone (or the XXXphedrones where xxx is the parasubstituant) 1920's wasn't it? and then forgotten about until some drug chemist was paging through the merck index or something looking for the word "stimulant" and cooked some up.
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What a jaded view you have of unofficial research! =D
 
Well, I just received my buphedrone, and I have to say I think it's quite a bit more potent of a stimulant than people make it out to be.

I had done a 5mg allergy test just to be safe. I did not appear to be allergic to the compound, so I sniffed 25mg. After about 10 minutes I started to feel some pleasant stimulation, but there was no 'rush' as noted by several others.

However, about a 2 hours later, I was feeling tired and wanted a bit more, so I put out about 30mg on tinfoil and chased the dragon. It vaporizes GREAT, and I have to say it felt like smoking rock. I mean I was getting pretty decent RUSHING for 10 minutes or so. Couldn't stop moving, running across my dorm back and forth, smoking is DEFINITELY the way to go for this substance. Alot of euphoria surprisingly. (I had smoked JWH-018 about an hour earlier, maybe that played in) The rush was gone mostly after like 15 minutes, but those 15 minutes felt like an hour. After that stimulation steadily decreased over an hour.

It should be noted that there was plenty of residue left on the tinfoil, and my actual smoked dose was probably closer to 20mg.
 
Could anyone with blood pressure cuffs do us a favour and take your BP and pulse and 20-30 minute increments before and after dosing? Everyone says this is easy on the PNS but I'm curious as to measurable cardiovascular effect.
 
nuke said:
Could anyone with blood pressure cuffs do us a favour and take your BP and pulse and 20-30 minute increments before and after dosing? Everyone says this is easy on the PNS but I'm curious as to measurable cardiovascular effect.
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i'm getting some soon will check the pulse:)
 
pofacedhoe said:
i really want to smoke it now- would you say the fiending was worse than snorted? i find it insanely feindish snorted;)
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It IS very fiendish, but you're not even really chasing a high it's weird, you just want to do more...

I mean, it feels good, but not to the point where it would justify doing a rail every half hour.

I checked my scale, it was not calibrated correctly, it's possible the dose I smoked last night was as high as 50mg 8o
 
yeah i found it difficult not to do a rail every ten minutes-small ones though. i think this problem is heightened by cannabis use
 
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