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1-Phenyl-2-methylaminobutan-1-one

Ohh i'm excited! I found a lot of chat about this in the old Stimulants of the Future (the first one) thread:

http://www.bluelight.ru/vb/showthread.php?t=171971&highlight=stimulants+future&page=15

Sounds like it might be pretty good..

random snippits:
(f&b)
About 10-20mg for 1-phenyl-2-(N-methylamino)-1-butanone - that's from memory. Give me a mo and I'll have a rummage and see if I can verify that .

I do remember that it seems to have the right dopaminergic/noradrenergic activity to produce a reasonable amount of euphoria - a lot better than methcathinone, which I've found can leave you feeling a bit 'jittery' (I'd guess down to adrenergic activity). Of course if you bung a meyhtylenedioxy ring onto it, you still end up with an entactogenic like activity. That's quite unlike the 5 carbon valerophenones that disp;lay almost no such erffects (MDPV causes some colour brightening.enhancement with higher doses, but very little else).
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Yeah, apparently the degree of dopaminergic reuptake inhibiton increases with chain length up to a 6 carbon chain - thing is the effects on the noradrenergic system go down with increasing chain length (which is why MDPV is almost exclusively dopaminergic in action). If you want euphoria as opposed to something for attention/focus control, you need some adrenergic activity
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vecktor said:
this material has been around for a while and goes back as far as the Hive, but there is still no decent data.
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I SCOURED the Hive archive looking for info, but unfortunately the search function does not work properly. in the process i stumbled across a very interesting thread from '03 which not only mentions buphedrone but also seems to contain the first reported synthesis and bioassay of mephedrone. the two are compared and the author says that mephedrone is more euphoric. is there other info about buphedrone on the Hive that im missing?

its a pretty fascinating read, who would have thunk mephedrone would become one of the most popular RCs in history.

http://dixie-flatline.org/thehive/novel/000423945.html
 
yaesutom, f&b never verified that figure although I'm not entirely sure what question he was answering. Threshold activity perhaps?

Activity will be reduced by chain lengthening. If it isn't I'll eat my hat. It will also be halved again by the presence of 50% junk R- isomer (MCAT produced from the oxidation of pseudoephedrine gives S- isomer only, the more potent form), this will almost certainly be the racemate.
 
Activity will be reduced by chain lengthening. If it isn't I'll eat my hat.
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I hope your hat tastes good, since beta ketones actually get more active with lengthier chains, up to 6 carbons...
 
The activity begins to fizzle out at greater than or equal to 5 carbons. But, the longer the sidechain the more likely the compound appears to be a DAT/NET substrate than a releaser.
 
dread said:
I hope your hat tastes good, since beta ketones actually get more active with lengthier chains, up to 6 carbons...
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That's true for pyrrolidinyls. But does it hold true for amino and methylamino compounds? I'm not so sure. Where is the great leap in potency from methylone to butylone? There is none.

And as I said earlier it will almost certainly be racemic and therefore 50% w/w the largely inactive isomer, junk.
 
In my experience, butylone is a tad bid more potent than methylone indeed, but their DA/NE/SE affinities is not nearly the same (as for the experience, the same, but not really...) so 150mg methylone is not = 120mg butylone for me.

I'm looking forward to hear more on the butyl-drone, and will most likely taste it carefully within a months time. This is sure getting a lot of hype at the moment.
 
dread said:
Butylone > Methylone.
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And yet trip reports on erowid, and elsewhere, over and over again describing equivalent doses of butylone as subtler, weaker, something missing. Something about that extra carbon pleases some and not others. I admit though, activity is probably the wrong word. So my bad. Like nuke said, the longer side chain changing activity rather than reducing it. Relative potency is probably closer to what I mean. The whole subjective package feeling somewhat less powerful.
 
Methcathinon and Buphedron are both simple stimulants and can be compared better than the entactogens.
 
after some trails with this chem at 20mg and 30mg it has proven it to be an incredibly smooth and reasonably euphoric stimulant with many of the qualities daily users of stimulants look for. although some people have posted their doubt that it has serotonergic activity this has in no way been proven and i think it should be treated as if it will have (at least) the toxicity of MCAT until someone steps in and proves convincing evidence otherwise (unsupported extrapolations of the presumed (but unknown) pharmacology of butylone not withstanding) ie do not use without the whole neuroprotective family: ALA, NAC, N-acetyl-carnitine, ascorbic acid, and melatonin.
i also should note that i "look forward" to taking it each day, this is significant in that i have a very nonaddictive personality and any drug which i find myself "looking forward" to probably has some serious potential for misuse. i could easily imagine this chem getting into MA like territory in higher doses, and as the posted report from the hive evinces, abuse on this chem is not unknown. lets hope people are turned off by is its relative lack of euphoria in comparison to mephedrone (which i have never tried so im going off the reports of others).

also the bulk price has virtually doubled, which is a fucking bummer, im not sure if this is an indicator of demand or a preemptive deterrent of demand in the vein of charging exorbitant prices for DOB-DFLY...
 
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^^ you got my hopes up :) Especially where you say its more like amphetamine and not MDPV (in that other post of yours).

A guy on another forum took 100mg and claims it wasn't all that strong, says he doubts the purity of his sample:
Male, 78kg.
No tolerance with cathinone.


First try: 2mg (allergic test) following by 30mg (oral administration):

T-0:00: Empty stomach. 45mn after the allergic test, passed over without problem, 30mg was ingested, product placed on rolling paper.
The guy go to work.
T+0:30: Without high/body high, no sign of coming up, the effect are present. Light stimulation. Clear mind.
The complete panel of effect were limited to this. Not particulary more sociability, like urge to communicate or emphaty. Euphoria is absent.

The effect was still present after 3h.
T+3:00; this light effect was really present during all this time. After this they totally disappear, no after effect, they just disappear. No hangover.

During this test i didn't notice any strong physical side-effect.
No desire to redose like with mephedrone or methylone.

At this dosage it's more a cafeine tachycardia-free than a bk-PEAs.

Second try: 20mg (snuff) 3 days after the previous test.

T+0:00: Empty stomach. 20mg snuffed, the taste wasn't so weird. Not too strong, no pain in the nose.
T+0:10: First effect arrive, little high with the coming up, not very euphoric but some "buzz" in my mind.
T+0:15: Plateau, clear mind, middle stimulation. The same effect than the other day with 30mg ingested.
Always without empathy or euphoria. Just stimulation.

The effect (plateau) was present for 1h/1h30

T+1:30: coming down, no hangover.

During this test I ingest some food, a normal portion, without problem.
The desire of redose was a little bit more present, but if I didn't redose, it wasn't a strong feeling.^^

Third test: 80mg (oral) + 20mg (snuff) the following day.

T+0:00: 80mg was ingested, Empty stomach.
T+0:15: 20mg snuffed.
T+0:35: Coming up, no more high than the other time, just a strongest stimulation coming up more quickly.
T+0:45: Middle stim, the same panel of effect than the 2nd test. No more.
T+1:30: I'm waiting for stronger effect than the previous test, but they didn't arrives. So i eat a big burger...that's good, no problem to eat.

The only advantage of this dose was the duration of the effect, 6 hours.

T+6:00: Coming down, no hangover.

After this last test, with 100mg, I can say that it's a nice middle stim, recreationnal value are very limited, non-existent for me.
A good point was the absence of physical side effect and no hangover even with larger dose.
You don't want to redose.
You can eat.
Nobody can't see that you're under influence...(sometimes even yourself...)

Just a middle stim. Uninteresting for me.
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pardon my desoxypipradrolsih rants, as i realize this is ADD and not the place for endless updates on the minutiae of my inner experience, but i would also like to add that buphedrone has no prosocial aspect to it like amphetamine, in fact it produces a hyperanalytical robotic sort of thinking that makes interacting with other people stilted and awkward. it also has a very real "seriousness" to it. in some ways i would compare it to 4-FA more than anything else (to which i had an atypical reaction, i found 4-FA very "serious" and talking with my friends was a heavy emotional task) for the additional euphoria it produces over MPH it also has a pretty significant comedown...perhaps my initial observations were too positive.

EDIT: it seems extending the alpha position is ultimately a futile exercise, yes more bang for the buck but the price is an unavoidable increase in weirdness (moiré patterns in stripes/visual flanging (not in a psychedelic sort of way but in a heat stroke sort of way) repeated wondering if i am "acting normal") MDPPP, aPPP, and so many others excel with their modest alpha methyls, and christ look how people respond to PEA - the alpha castrati!
 
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its very strong but feels mostly dopaminergic- great with some nice weed to smoke but on its own kinda boring and addictive- best orgasms ever though, easy to reach one after another.

most addictive redoseing i have had since really nice cocaine. brutal but short comedown, back to normal in two days. a lot of overlap with mephedrone in terms of redose and comedown except felt far less shitty and spaced out after buphedrone and far hornier while on it.
 
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The chain lengthening effect on potency doesn't seem as important if you include the alpha group in a ring structure eg methylphenidate, desoxypipradrol etc. Even fencamfamine, with a possible 5 carbon chain attached to the alpha position (in alicyclic form) is still reasonably potent (and a monoamne releaser at that, although only 10% that of amphetamine)
 
And zylofuramine. Don't forget zylofuramine.

220px-Zylofuramine.svg.png
 
Sounds interesting. I will be tasting this in the coming january, and post up my results.
 
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