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How toxic is Mephedrone?

Why are you not at the dr's and addiction clinic describing these symptoms?
They are get round able.
You are going to either fuck yourself up very much or die, but I'm reckoning you know that.
SSRI's say fluoxetine could poss help you with the zaps and serotonin fuckery.
Describe the seizure like effects in detail to a medical professional. There are a number of drugs to help with this.
6 months now and yeah I don't know where your money is coming from, and its not my business......cash flow has always been the staunch underpinning of any of my problems. If I can't buy 2 litres of gin a day then I can't keep a 2 a day habit up.....etc.
You want to write a new journal where we have no connection to you, when this place is the best place for you apart from strapped to a hospital bed with multiple lines in your arm and a possible week - month stay ahead of you.

This place is harm reduction and you can still use it if you come back more often. Did you see the meph addiction thread.....they had it very softcore to you.

I'm not certain why you are still doing this to yourself? Is it that there is still a high attainable that you crave THAT badly? Or is it to stop some of the negative symptoms?

Do you want to write anonymously so various people on here won't just let you die? Are you suicidal? Do you want to die? I don't think so.


There are some people in the health service willing to listen to people with drug problems, with drugs they know nothing about. They aren't all ignoramuses who don't think that a new drug isn't knocked up every day, possibly 1 in 10 with the potential for addiction?

Dr,Addiction centre, Hospital and go through however many pepole you have to....the Hippocratic oath they have taken should by law prevent from refusing you treatment and if you reach the right one you might get the right treatment.
 
Brokenbrain, the only reason I think it would be good to write anonymously is to offer an extra layer of protection from being identified. I'm not suicidal, don't want to die, have a great job and life, etc.

But...

You make a damned good point. You've given me a lot to think about - thanks :)
 
RE: vasoconstriction

Cocaine is also a vasoconstrictor, yes?

Say one binged on coke - would this be more or less toxic than mephedrone, hypothetically?

Are the physical effects of bingeing on coke comparable to mephedrone?

(Cocaine does nothing for me, so I've never taken more than a few lines in my life, so excuse my ignorance.)
 
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It's a bit tough to say, as we'd be comparing typical stimulant related vasoconstriction with cocaine, coupled with additional cardiotoxicity from calcium channel blocking activity, to mephedrone, which metabolizes to a very toxic, long-lasting vasoconstrictor. I'd have to say that epidemiological data appears to suggest that cocaine would be safer.

ebola
 
ebola? said:
It's a bit tough to say, as we'd be comparing typical stimulant related vasoconstriction with cocaine, coupled with additional cardiotoxicity from calcium channel blocking activity, to mephedrone, which metabolizes to a very toxic, long-lasting vasoconstrictor. I'd have to say that epidemiological data appears to suggest that cocaine would be safer.
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...but (correct me if I am wrong as I am way out of my league here!), doesn't cocaine present an additional danger with its anesthetic effect on the heart due to blocking of sodium ion channels?
 
I have to agree that cocaine would be safer, mephedrone seems to cause long lasting vasoconstriction in some ppl which lasts up to more then 6 months:\.

Anyone has an idea how the hell that is possible?
 
following on my from post #539...

Had 1/3 a gram mixed into a jager bomb on xmas eve. I was already drunk but like mdma does to me it sort of sobered me up, i can remember feeling fantastic. talkative a bit emotional and horny. Very energetic but wasnt on a dance night as i usually am so just very friendly and talkative. Lasted a few hours. I then left town, had a couple of beers with mates and jogged home a couple of miles.

Couldnt sleep too great at night but felt suprisingly ok on xmas day and was up at 8.30am after getting in at 4.30am. Felt shit later on around 5pm but after eating and drinking water was fine. mdma makes me feel bad but not too bad for around 3 days. This stuff makes me feel really shit for a few hours but then fine

Overall for the £12 a gram it costs its worth it. Im a bit scared about the fact noone really knows what is it in but cant be much worse than the dodgy pills ive been getting for the past few years. Its definately going to get banned soon as its a LOT stronger than coke and a bit like mdma (IMO)...

Time to get a few more grams of it before its illegal! Something new will come out in its place im guessing

edit - If it is just plant food, can i go to a garden center and buy a bucket of the stuff? Or is it shipped from China or somewhere?
 
alex1236 said:
edit - If it is just plant food, can i go to a garden center and buy a bucket of the stuff?
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No harm in asking, everyone else is selling it these days.

I was lying awake this morning listening to the science segment on 'Up All night' on radio 5.

Someone asked why dogs get poisoned by chocolate, yet humans don't.

It's because of the active substance theobromine. We humans metabolise it fairly easily. It has a half-life of seven hours. But animals like dogs and cats metabolise it slowly. It's still in their system days later if they eat enough. And then it poisons their heart and other organs.

Now, some people may think that:

mephedrone is a bit like MDMA, speed and coke - ergo we excrete it like those substances.

But the theobromine/doggy comparison shows that similar substances can have very different effects based on their half-lives.

Some scientific types round here are suggesting that mephedrone has a very long half-life. A scarily long half-life. In other words, we don't excrete it easily; and the more you take, the more it builds up. So if it does do nasty things to you, like harden your arteries and restrict blood flow to your extremities, you may exacerbate it with daily/weekly use.

Of course, there's been no definitive scientific study done, and a lot of the conjecture is based on ephedra-type chemicals.

The fact that we don't the know the half-life of mephedrone is scary enough in itself.

By the way, restriction of blood flow to the extremities includes the penis. I've certainly noticed blood-flow problems down there after major binges.

I also seem to have a lower sex drive. Not that I can't get wood; I'm just not as interested in sex. When I'm on the stuff I can get hyper-sexual; the rest of the week I'm barely interested. Which is mostly OK as I'm single; however I don't want to chemically castrate myself.

I also reckon it won't be doing your teeth enamel any good. I've already damaged my teeth badly through a combination of meth-sulf, crystal meth, pepsi max etc, but after 9 months of mephedrone/m1 use one of my teeth seems to have gone translucent. Ho-hum, that's another lie I've to tell to my dentist in a few months.
 
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Interesting. When i was younger i fed our dog (german pointer) chocolate all the time. She loved it and died of old age at 12. I cant comment on the stuff building up inside you because I am not a scientist type either. I would like to know what the buildup does to you because whilst i do enjoy drugs every now and again I am also quite heathly, eating healthy food almost all the time and exercising daily usually.

You are right about it making you 'hyper-sexual' But on xmas day i was extremely horny (not good!) and on boxing day i had a banging wank. I had another the day after (yesterday) and had one earlier too. So all is good on the blood circulation to penis thing. My feet have been a bit cold but they normally are anyway, maybe it has redirected more to my dick than my feet usually...Great!
 
...but (correct me if I am wrong as I am way out of my league here!), doesn't cocaine present an additional danger with its anesthetic effect on the heart due to blocking of sodium ion channels?
Click to expand...

Sorry...I accidentally said "calcium" instead of "sodium".

Some scientific types round here are suggesting that mephedrone has a very long half-life. A scarily long half-life. In other words, we don't excrete it easily; and the more you take, the more it builds up. So if it does do nasty things to you, like harden your arteries and restrict blood flow to your extremities, you may exacerbate it with daily/weekly use.
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Actually, it would be a first order metabolite, 4-methyl-ephedrine, that has a very long half life. It is also very likely this metabolite that is so cardiotoxic and vasoconstrictive.

ebola
 
noone really knows what is it in but cant be much worse than the dodgy pills ive been getting for the past few years
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Oh it most certainly can be worse than dodgy pills


But animals like dogs and cats metabolise it slowly
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Chocolate isn't toxic to cats on a weight for weight basis. Dogs it def is


Some scientific types round here are suggesting that mephedrone has a very long half-life
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Not mephedrone, but it's metabolite 4-methylephedrine (it's the metabolite that causes all the dodgy stuff to happen)


You are right about it making you 'hyper-sexual' But on xmas day i was extremely horny (not good!) and on boxing day i had a banging wank. I had another the day after (yesterday) and had one earlier too. So all is good on the blood circulation to penis thing.
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Don't count on it staying that way


edit - If it is just plant food, can i go to a garden center and buy a bucket of the stuff? Or is it shipped from China or somewhere?
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No source questions (or the banhammer may be activated)


ps Fast And Bulbous: I know, I'm a massive tool... ;o)
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Nope, you're an addict (a labrl I'm unfortunately familiar with). I reserve 'massive tool' for those getting such symptoms, but who are in denial that it's the mephedrone causing their health problems
 
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fastandbulbous - What if this was used in dodgy pills? Im sure i have tasted something similar before. I tasted some white 'atomic bomb' pills that tasted very chimically and had a similar sort of taste

Sorry about the source question, i didnt want to know what garden centre or whereever. Just if this stuff was coming from china or somewhere else or could anyone just walk into a store and buy 10kg of the stuff
 
Dodgy pills usually have piperazines. Although, with the cheap prices of mephedrone it will only be a matter of time until someone starts pressing pills of it...
 
dread said:
Dodgy pills usually have piperazines. Although, with the cheap prices of mephedrone it will only be a matter of time until someone starts pressing pills of it...
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In my area mephedrone pills have been around for months. Wont be suprised if soon mephedrone replaced all piperazines.
 
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Don't know but apparently 4-methylamphetamine has a long half life due to removing one of the potential routes of metabolism amphetamine undergoes (4-hydroxylation). If it also stops MAO from doing it's job, them all the major routes of metabolism have been stopped
 
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