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Bupe Suboxone/Buprenorphine FAQ and Megathread v.1; 2007 - 2010

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Regarding marijuana policies, when first put on my program after pissing I told the doctor "It's going to be dirty for pot too." He asked why I smoked, I said that it helps me sleep and it helps me go longer without needing more dope by covering withdrawals. He told me that "We have a no drug policy and marijuana is a drug." and I told him that it wasn't going to change and that I could go to one of the other many doctors in my city, he accepted it.
 
Suboxone Insomnia!!

Well here I am again sitting in my room, its 2:23am )... Anyways I do not miss the Insomnia caused by none other than the Bupe.. Not many other people I know can relate with me on the insomnia caused by subs. I am known for saying things like "omg suboxone gives me worse insomnia then if I were on cocaine or XTC" which is probably why most of my friends think i am exaggerating but I disgress, i am not... I always had an insomnia problem my whole life, even b4 I ever knew what an opie was or any drugs for that matter... But i swear to god Subs give me the worse insomnia, its not like insomnia from a stimulant (btw i hate stimulants) or is it like insomnia from opiate w/ds because i feel fine, i just cant sleep worth a shit... and here goes my last 2 ambiens down the hatch....god im not lookin forward to tomorrow night..:p
 
and actually, as an addendum, IVing bupe is actually less effective than sublingual. B/c off absorption rates and such, the naloxone tends to block even the agonist. Naloxone doesn't absorb at all sublingual but it's efficacy is huge when IV'd. So put em under yr tongue, you'll be fine.

"Effective" can mean different things for different people.

The duration of sublingual buprenorphine lasts longer than IV buprenorphine, but the bioavailability of buprenorphine IV is much greater than the sublingual bioavailability.

Naloxone is absorbed with all ROA's, but it does not out compete the mu-opioid receptor - buprenorphine's binding affinity to the mu-opioid receptor is better than that of naloxone. Naloxone also is metabolized out of your system first. Naloxone is an essentially inert ingredient - and has no pharmacological effect, even if you shoot it.

Thanks for your misleading post though.
 
Well here I am again sitting in my room, its 2:23am )... Anyways I do not miss the Insomnia caused by none other than the Bupe.. Not many other people I know can relate with me on the insomnia caused by subs. I am known for saying things like "omg suboxone gives me worse insomnia then if I were on cocaine or XTC" which is probably why most of my friends think i am exaggerating but I disgress, i am not... I always had an insomnia problem my whole life, even b4 I ever knew what an opie was or any drugs for that matter... But i swear to god Subs give me the worse insomnia, its not like insomnia from a stimulant (btw i hate stimulants) or is it like insomnia from opiate w/ds because i feel fine, i just cant sleep worth a shit... and here goes my last 2 ambiens down the hatch....god im not lookin forward to tomorrow night..:p

How much buprenorphine do you take? When do you take your last dose of the day?
 
Actually, very little of the naloxone is absorbed when your suboxone is taken sublingualy, but all naloxone will be absorbed if your suboxone is taken IV. I tried IVing my suboxone last night. It wasn't shit. I really felt less from it than I do when I take it under my tongue. And it made me kinda sick feeling. I didn't like it at all.
 
It stabilized a bit after 3 days now at 8mg of buprenorphine but I'm feeling like I were almost hitting the point where tapering down would be very difficult. I take 2mg less every weekend to find myself somehow at a dosage, then I continue taking the same amount during the week. I don't know if I will jump to 6mg this weekend. Probably too fast. 8mg isn't still working like I feel it should. Anyway I thought that my starting dose that set me up good - 16mg - was quite high daily while I switched to bupe from around 120-160mg morphine twice a day/40mg levorphanol once a day. Well, anyway dividing doses by 30-40 gives only equivalent dose for analgesic effect. Whatever. Good I'm way lower than 16mg now. Still, I used fentanyl analogs to break through buprenorphine a few times.

Naloxone is absorbed with all ROA's, but it does not out compete the mu-opioid receptor - buprenorphine's binding affinity to the mu-opioid receptor is better than that of naloxone. Naloxone also is metabolized out of your system first. Naloxone is an essentially inert ingredient - and has no pharmacological effect, even if you shoot it.

Yeah, nice try to scare junkies from injecting pills. But some researches reveal that naloxone in Suboxone MAY have some unpleasant additive effects no matter if taken s.l or i.v.
 
But some researches reveal that naloxone in Suboxone MAY have some unpleasant additive effects no matter if taken s.l or i.v.

What might be these unpleasant additive effects be that you speak of?
 
Actually, very little of the naloxone is absorbed when your suboxone is taken sublingualy, but all naloxone will be absorbed if your suboxone is taken IV. I tried IVing my suboxone last night. It wasn't shit. I really felt less from it than I do when I take it under my tongue. And it made me kinda sick feeling. I didn't like it at all.

I don't find that to be true Puppy Dogs. Though I do think that I get more pleasant effects from sublingual--yes, sublingual--Suboxone than I do from IVing Bupe, IVing it does not cause any type of precipitated withdrawal.

It seems to me that saying you get "a little naloxone" by IVing is like saying that you are "a little pregnant." If the Naloxone were active in Suboxone than I would have had terrible precipitated withdrawals every time I've IVed Suboxone. But that hasn't happened. So none of the Naloxone is active.

I really have to believe that any illness you felt last night, Puppy Dogs, was in your head. The Placebo Effect could make you think that you are sick if you THINK you will be by IVing Suboxone. Pleacebo REALLY is that strong, especially for people like me who have made IVing drugs a (very unfortunate) lifestyle.
 
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Well here I am again sitting in my room, its 2:23am )... Anyways I do not miss the Insomnia caused by none other than the Bupe.. Not many other people I know can relate with me on the insomnia caused by subs. I am known for saying things like "omg suboxone gives me worse insomnia then if I were on cocaine or XTC" which is probably why most of my friends think i am exaggerating but I disgress, i am not... I always had an insomnia problem my whole life, even b4 I ever knew what an opie was or any drugs for that matter... But i swear to god Subs give me the worse insomnia, its not like insomnia from a stimulant (btw i hate stimulants) or is it like insomnia from opiate w/ds because i feel fine, i just cant sleep worth a shit... and here goes my last 2 ambiens down the hatch....god im not lookin forward to tomorrow night..:p

You're definitely not alone here ,I do suffer from exactly the same thing but I believe we junkies tend to avoid discomfort at all costs and we're so used to total opiate induced numbness that we blame every painful/uncomfortable thing on opiates or substitutes or withdrawals or whatever...I'm aware part of my sleep issues originate in me spending all day doing fukk all and partly blaming opiates and treatment for traits(like laziness to name but one) which were already part of who I'm long before I got involved with junk ...I suspect if one puts some effort , and I mean EFFORT in being active all throughout the day by working or involving yourself in anything which demands you stick to some daily routine all these issues will go way ...aware I'm speaking out my ass in here ,but I guess we(at least i speak for myself)'re just too used to rely on some"magical pill" to make things happen.
 
I need some assistance

I've been on OC for the last 3 years, bouncing back and forth between OC and Subuxone. I'm wanting to pick up H for the first time for a friend and myself. How much should I get? We usually will do 4-80mg OC between us...Can somebody help me out please??
 
I've been on OC for the last 3 years, bouncing back and forth between OC and Subuxone. I'm wanting to pick up H for the first time for a friend and myself. How much should I get? We usually will do 4-80mg OC between us...Can somebody help me out please??


I think you should make a new thread for that question.. I don't know if it will get answered in the suboxone thread.. you never know though.. it might.
 
I've been on OC for the last 3 years, bouncing back and forth between OC and Subuxone. I'm wanting to pick up H for the first time for a friend and myself. How much should I get? We usually will do 4-80mg OC between us...Can somebody help me out please??

if you guys score the proper stuff ,1/4 of a gram is enough to have both of you stuck down deep in Nodville for at least 24 hours
 
Actually, very little of the naloxone is absorbed when your suboxone is taken sublingualy, but all naloxone will be absorbed if your suboxone is taken IV. I tried IVing my suboxone last night. It wasn't shit. I really felt less from it than I do when I take it under my tongue. And it made me kinda sick feeling. I didn't like it at all.

Suboxone isn't meant to be IV'd. Additionally, it's not at all long lasting and you won't get the positive effects with a high tolerance.

If you heated the solution, you may have destroyed the buprenorphine.

Additionally a lot of people don't like shooting a lot of Suboxone (anything more than 2mg at once is the reason why you didn't like it IMO if you actually tried it with more than 2mg).

The naloxone did not prevent the buprenorphine from being active and out-competing the naloxone when you IV'd it. That's still incorrect.

It stabilized a bit after 3 days now at 8mg of buprenorphine but I'm feeling like I were almost hitting the point where tapering down would be very difficult. I take 2mg less every weekend to find myself somehow at a dosage, then I continue taking the same amount during the week. I don't know if I will jump to 6mg this weekend. Probably too fast. 8mg isn't still working like I feel it should. Anyway I thought that my starting dose that set me up good - 16mg - was quite high daily while I switched to bupe from around 120-160mg morphine twice a day/40mg levorphanol once a day. Well, anyway dividing doses by 30-40 gives only equivalent dose for analgesic effect. Whatever. Good I'm way lower than 16mg now. Still, I used fentanyl analogs to break through buprenorphine a few times.

Don't get discouraged man. It may seem difficult to taper past 8mg, but it is possible. Plus, you can go at a very slow rate going down. You can always take more if what you take isn't enough. Instead of dropping down 2mg less, I would try 0.5mg or 1mg less (8mg to 7.5mg or 7mg). I think that would be easier for you than dropping 2mg at a time.
 
I think you should make a new thread for that question.. I don't know if it will get answered in the suboxone thread.. you never know though.. it might.

NO - he should NOT make a new thread for this question.

It WILL be closed.

He's asking in other pre-existing threads, and he's already gotten 2 answers. Let him do his thing.

ALSO

As a reminder to everyone here, we don't list prices in this thread. We only do it in the 2009 Price Thread. That's about it.
 
Do any of you guys happen to know whether one can undergo interferon treatment for hepsC while still staying on Sub maintenance or does one need to be completely clean in order to do so ? Last time I was so concerned about other issues such as the severity of my viral load and measures in order to improve or at least maintain my liver's health and so on that I forgot to ask my physician this question ... thanks guys and sorry for the 2 posts above which have nothing whatsoever to do with Subutex or anything else for that matter lol
 
Another thing I've been wishing to know is whether you can use Methylone safely while on Sub .The other day I just passed that cause I was already on Trams and Bupre and didn't think it was wise to add a stimulant I knew next to nothing about to the mix
 
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