• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

LSD and Serotonin Syndrome

dimensiontripping

dimensiontripping

Bluelighter
Joined
Dec 7, 2007
Messages
331
Location
East Coast
Does LSD ALONE have any connection with serotonin syndrome or has LSD ever induced a case of serotonin syndrome in someone before?

I recently found some data on this but have never heard of such a thing.

it also associated MDMA, MDA, and MDEA as possible catalysts for serotonin syndrome

How would a drug user actually get serotonin syndrome? I know result of Serotonin Syndrom is the overstimulation of 5-HT1A receptors in central grey nuclei and the medulla but would you not have to pull a serious drug combo for this to happen or can a single substance cause this?

to say the least, the syndrome sounds slightly terrifying.
 
^I do believe it can happen to anyone when manipulating any seratonergic levels with drugs, but is rare. Every refernce I've read to that sort of effect seems more theroetical then based on factual reports- like it should be able to happen.... Any dose of an SSRI can give anyone seratonin syndrome fwiw.
 
dimensiontripping said:
Does LSD ALONE have any connection with serotonin syndrome or has LSD ever induced a case of serotonin syndrome in someone before?

I recently found some data on this but have never heard of such a thing.

it also associated MDMA, MDA, and MDEA as possible catalysts for serotonin syndrome

How would a drug user actually get serotonin syndrome? I know result of Serotonin Syndrom is the overstimulation of 5-HT1A receptors in central grey nuclei and the medulla but would you not have to pull a serious drug combo for this to happen or can a single substance cause this?

to say the least, the syndrome sounds slightly terrifying.
Click to expand...

I doubt lsd would do that. MDxx substances and combinations with those might give you serotonine syndrome in high dosages. I'm not completely sure what it is.
 
I don't think there's ever been a recorded instance of it. Candyflipping seems as though it might be slightly riskier but probably the chance is remote. The real risk involves SSRI's and, apparently, DXM
 
yeah, I have heard DXM + MAOI/SSRI can be a DISASTER

and alone, I have heard DXM can cause problems like that (which correlates with my monodrug thought connected with serotonin syndrome).
 
seritonin syndrome

I had what I believe to have been seritonin syndrome last weekend and I only took two 'legal highs'. I am an experienced user of mushrooms/MDMA/LSD etc and I had these before, but they gave me a really bad reaction this time-took one at 2am and one at 5am and was really high- my jaw was moving on its own and my eyes were moving about everywhere, this I could handle, but I started to get really hot a few hours later and ould not cool down, at 9am I couldn't breathe, I had pins and needles all over my body, including in MY FACE and I thought I was going to die. I think I went into metabolic acidosis. Anyway, this lasted for 2 hours and eventually went away. The only explanation I can think of is that I had taken my daily st John's wort about 12 hours earlier....maybe that had a bit of an effect as it is an SSRI? I hadn't even drank that much alcohol- I didn't feel drunk anyway.

The capsules were called decibels and are labelled plant feeder 'not for human consumption' and it says on them that it contains 250mg of ketones.

I took LSD this weekend and was fine.

The only other bad reaction I've had was with Yohimbe and as it is a MAOI and I had forgotten that I'd eaten cheese earlier, I got pretty unwell, felt like I had the flu.
 
Those ketones would most likely be cathinones, possibilities are (not limited to):
4-methylmethcathinone, 4-methoxymethcathinone, dimethylcathinone, diethylcathinone
 
the "classic" psychedelics don't really manipulate serotonin levels in the same way that cathinone's and mdxx type things do. The latter should have no risk of serotonin syndrome, but the former could, potentially, though I've never personally read an actual case of that happening.
 
any major dude said:
the "classic" psychedelics don't really manipulate serotonin levels in the same way that cathinone's and mdxx type things do. The latter should have no risk of serotonin syndrome, but the former could, potentially, though I've never personally read an actual case of that happening.
Click to expand...

I would have though that the classic psychedelics would have much less risk of serotonin syndrome than (bk-)MDxx would. The former doesn't release serotonin like the latter do; it's the overabundance of serotonin that is serotonin syndrome.
 
fishandtatties said:
I had what I believe to have been seritonin syndrome last weekend and I only took two 'legal highs'. I am an experienced user of mushrooms/MDMA/LSD etc and I had these before, but they gave me a really bad reaction this time-took one at 2am and one at 5am and was really high- my jaw was moving on its own and my eyes were moving about everywhere, this I could handle, but I started to get really hot a few hours later and ould not cool down, at 9am I couldn't breathe, I had pins and needles all over my body, including in MY FACE and I thought I was going to die. I think I went into metabolic acidosis. Anyway, this lasted for 2 hours and eventually went away. The only explanation I can think of is that I had taken my daily st John's wort about 12 hours earlier....maybe that had a bit of an effect as it is an SSRI? I hadn't even drank that much alcohol- I didn't feel drunk anyway.

The capsules were called decibels and are labelled plant feeder 'not for human consumption' and it says on them that it contains 250mg of ketones.

I took LSD this weekend and was fine.

The only other bad reaction I've had was with Yohimbe and as it is a MAOI and I had forgotten that I'd eaten cheese earlier, I got pretty unwell, felt like I had the
flu.
Click to expand...


I had these legal highs . It took like 3 hours to kick in . I was feeling really hot and at times I was feeling like you ... But the thing I loved about these is the intense visuals . Like LSD but stronger !! Wow ! Next day I felt like shit though ...... What were the name of the legal high you had ?
 
I dosed some LSD right after a serotonine syndrom, and i can say that I felt way better after dosing the LSD than before.
I don't think it could cause it, but given the combinations it takes place in, one can't really assume...
 
PepperSocks said:
I would have though that the classic psychedelics would have much less risk of serotonin syndrome than (bk-)MDxx would. The former doesn't release serotonin like the latter do; it's the overabundance of serotonin that is serotonin syndrome.
Click to expand...

Ha, just caught a several year old typo on my part there. But yep, the releasers/reuptake inhibitors are what you need to worry about. Agonists not so much.
 
You must log in or register to reply here.
Top