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New opioid approved by FDA in the past few days: tapentadol

Very interesting. Yes, I will tell you guys exactly what it does. I am not as nervous now. Is it really sedating? Wow.
 
PinK~cloud said:
got one through a friend. i did it about 8 hours after .5 suboxone. i felt it which was suprising because my tolerance is high from suboxone. maybe it works like tramadol to suboxone. relaxing high, almost sedating, yet i felt no need to sleep. i would be interested to try it again when i'm off of suboxone.
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I'm MORE interested now! I'd love to have alternative pain relief for those of us on Suboxone.
 
I pulled up the "full prescribing information" from the website [1] specifcally curious about the inert ingredients:
NUCYNTA (tapentadol) Tablets are immediate-release film-coated tablets for oral administration. The chemical name is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2- methylpropyl]phenol monohydrochloride. The molecular weight of tapentadol HCl is 257.80, and the molecular formula is C14H23NO*HCl. The n-octanol:water partition coefficient log P value is 2.87. The pKa values are 9.34 and 10.45. In addition to the active ingredient tapentadol HCl, tablets also contain the following inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, povidone, magnesium stearate,and Opadry II, a proprietary film-coating mixture containing polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc,and aluminum lake coloring.

[1] http://www.nucynta.com/nucynta/assets/Nucynta-PI.pdf
 
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Well I finally got some free Nucynta, 12 50mg tablets. This is not going to be any detailed trip report. Part of the reason why, is I am very disappointed by Nucynta. Having started low, and then ramped up, all I felt was the mildest like tramadol buzz. Almost a faux codeine type buzz, but it really wasn't all there. Now, tramadol will make me positively GLOW in the right amounts, and I'm talking full blown opioid glow. Nucynta might not have some of the OD problems associated with it that tramadol really does, but making Nucynta CII and tramadol unrestricted makes the opposite of any sense. Even IF nucynta ws more ab-usable than tramadol (which it isn't), the increased dangers associated w/ tramadol usage would warrant control. But controls are awarded based on perceived abusbility, and not actual safety issues...sad. And sad that even using their own double standard, standard, they STILL didn't get it right. Trust me, tapentadol just sux. Tramadol is OH so much nicer. Tramadol is WAY more euphoric than tapentadol, and not talking SSRI. Tapentadol almost feels like nothing. It does help a bit with pain though, but that is it. Little to no abuse potential here IMO>
 
^^^that's so weird. I would never assume schedule II for something like this. I was interested/excited half way through this page when I saw it was schedule II and IV'able. But now I don't really know.

I'm not a fan of tramadol but they did do a good job of killing dope-sickness for me a few years ago. Maybe this stuff is as hit or miss as tramadol depending on the individual. If anyone else has a trip report post it up, I know I'm not the only one curious about this substance. I mean shit, isn't like every other schedule II euphoric??
 
Strange. Maybe it's Sched. II because they are planning (tentatively) on rescheduling some opiates like hydrocodone w/APAP due to the frequency of high profile people dying with the stuff in their system. I really dislike Ultram. I don't feel sick on any opiate (sic) except Ultram. 150 milligrams and I'll be vomitting. I feel wired, no warmth or typical pleasurable opioid effect. Nor does it work for pain. To me its just bullshit unless I use it during wd's.
 
I agree completely with Tchort; well said. I am not excited about this drug, but I'll admit I am quite curious.

NARIs have always seemed great in theory yet ineffective in reality. Reboxetine (Edronax) & atomoxetine (Strattera) disappointed me personally and from nearly everything I've heard from others, they do very little other than produce side effects. SSNRIs (Effexor, Cymbalta) seem no better. I suspect Effexor - the only drug amongst all these I personally found useful - helped because of the dopaminergic effects at high doses, the only sort of doses that were effective for me.

Then again, I don't have neuropathic pain so NA stuff wouldn't even help me in theory. But I still don't think that NA drugs are especially/dramatically effective for pain overall and I think research down this road is wasted. Instead of all these dangerously potent synthetics & antidepressant-mimics, I would like to see a return to morphine-backbone-based drugs, which I personally find much more analgesic. Of course, such drugs have a lower profit margin and more abuse potential, which makes their development much less likely. *sigh*

Maybe I'll be wrong and this drug will be AWESOME but I am not impressed by its structure and purported mechanisms.
 
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you guys, I blew it off. I got nervous about the "brand spanking" newness to it. I read a couple reviews and the people did NOT like it at all. HATED IT. So, it's too new for me. Sorry, I wish I could have given you all a nice review, but went back on Norco.
 
wiggi said:
^ What dangerous substances does the FDA allow pharm companies to add to pills to cause health problems?
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I think some people are confused. Atropine, found in Lomotil, is actually beneficial in decreasing gut motility which is a great benefit to a medication for diarrhea. Also acetaminophen and similar NSAID like drugs are known to have a synergistic effect with opioids and should always be used (when feasible) in chronic pain, cancer pain and even hospice patients.....although the FDA recognizes the doses should be a bit lower due to hepatoxicity and nephrotoxicity.

Most of the anti-abuse properties are merely a beneficial "side effect" for the pharma companies and also allow the drugs to be placed in less restrictive schedules, but the majority (not all!) are honestly there for therapeutic purposes.

I think that the future is capsaicin in snortable drug preparations. It's cheap easy and a little would go a long way (just enough to suck if snorted but not enough to cause the "burning ring of fire.") Also, we wouldn't have the whole fiasco with the gelling medications not releasing drug reliably.

EDIT: Totally beaten like a red headed step child by DJ Sim :( - sorry guys.....I was, uh, reiterating....yeah.
 
i got these as soon as they came out and they suck they dont do shit i took 8 50mg tablets chewed and didnt feel a thing
 
thenickster said:
i got these as soon as they came out and they suck they dont do shit i took 8 50mg tablets chewed and didnt feel a thing
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thats bullshit. maybe you didnt feel anything compared to a typical opiate/oid high but there's definitely something there. look deeper.
 
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