N&PD Moderators: Skorpio
How toxic is Mephedrone?
Sparky1986
Bluelighter
Well I'm sure people will appreciate it, even studying chemistry after a first glance that source seemed believable. Thanks for debunking it %)
I guess we won't have any information on 4-MMCAT's toxicity until some proper studies have been done, in place of speculative pharmacology.
immad
Bluelighter
Although I thought some of his statements were bullshit, I wasn't able to dissect it in such great detail. So thanks for wasting 20 minutes of your finite existence
lineartransform
Bluelighter
Much appreciated vecktor, there's a lot of contradictory information out there. Nice to see an accurate critique.
pofacedhoe
Bluelight Crew
touch it and you are a guinea pig
also the case is that a number of different users have noted from experience that if you take it the day after taking it a previous day you seem to require less than before for the same effect. this would suggest it has a weak maoi effect-if you have another explaination for this then spit it as the maoi one seems to make sense to me given this weird tendency
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pofacedhoe
Bluelight Crew
what you mean is that there are a load of opinions. personal experience may be of use with a drug but everyone has a different reaction based on chance, genes, etc. and these are no use for anyone to go on. they are only usefull to confer with others who have sampled to try and acertain some patterns that is common to everyones experience
and try and discuss curious ideas. not to sell anyone the idea that ideas are facts. facts can be explained by ideas but rarely are the two once and the same
long half life?
interference/synergy with the previous doses' metabolites?
enzyme (other tha MAO) inhibition?
sensitzation / reverse tolerance?
the doses in appear pretty huge form 200-300mg to over a gram, of a molecular lightweight is a lot of molecules, so there is likely to be widespread off target interactions.
vortex30
Bluelighter
In my experience with Mephedrone, one requires increasingly high doses each time during a single session. 100mg off the bat (insuffilated) will provide major effects, but by hour 10-12 on the stuff 100mg doesn't do too much. I think after the first few doses all the serotenergic effects are spent and one just gets dopaminergic stimulation and euphoria.
Hi guys. I did Mephedrone for the fourth time today with a cumulative dosage of around 600mg (somehow...) over around 6 hours from 2am to 8am this morning. I am still confused as to how I finished the gram off since I only remember taking a 100mg bomb and a couple of lines. This morning, at around 8am, maybe earlier, I started to notice my knees turning slightly purple. I had read about that teenager who overdosed and went blue in the face. Naturally, I start worrying a lot. It became worse and worse until my knees were completely blue and my feet were going really pale. It also happened to my arms, quite severely. I started getting confused and tired. I had developed two red rashes one on my shoulder and one on my thigh. I remember watching the blue spread across my arms until i was covering the majority of the "outsides" of my arms. I kept breathing really deeply to try and slow my heart down and get more oxygen to my body. My hands were really blotchy with red and purple. My limbs had lost temperature and were pretty numb and as I looked in the mirror my ears my pale and slightly tinted blue along with my face. I looked closely and my lips were becoming blue as well. I tried to get the energy to phone an ambulance at this point as I thought that was the end of me. However, Very VERY luckily the side effects peaked and started to subside. I lay in bed breathing deeply for around 2 more hours until my limbs were nearly the correct color. Even now, 12 hours since the first dose (and the majority) and 6 since the final dose of around 50mg, my limbs do not feel right, especially my knees. If I cross my legs now my knees start going blue.
This is the scariest experience I have ever had with drugs and it has put me off RCs for life that's for sure. I am confused as to why the problems started when the effects had pretty much gone, around the time I started coming down.
I have taken equivalent doses before and had no side effects what so ever. Does anyone know WHAT THE HELL happened to me? I'm scared that I have caused permanent damage to my cardiovascular system. I also still have poor motor skills and very slow cognition which hasn't changed since I was high.
I am left now with tachycardia, unwanted stimulation, anxiousness, depression, confusion, forgetfulness, half dead limbs, apathy and confirmation (for me at least) that Mephedrone is not worth the risk and it has serious toxic effects on the body.
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congratulations lab rat, looks like you have discovered that abscence of evidence of harm is not evidence of the abscence of harm.
sounds like vasoconstriction, perhaps due to alpha adrenergic activity of the hydroxy metabolite, and if your limbs don't actually die or have to be amputated they will recover eventually.
breathing deeply makes no difference, the tissue oxygen levels are not going to be much effected, because the oxygenated blood is not getting where it should, deep breathing can cause other problems due to hyperventilation.
this drug and its parafluoro relative should be left alone, it appears to have killed at least once and is responsible for hospitalisations in the UK.
just so you know what vasoconstriction caused by RC's looks like:
the toxicology profile of mephedrone at the moment seems very similar to that of PMMA paramethoxymethamphetamine and PMA which has killed scores of people.
I make no apology for posting these images (incidentally they are from a bromodragonfly overdose) if it stops one person from dying.
taking these things is always a gamble but the downside risks in this game can be very high, if you treat these things as harmless fun and don't afford them the respect they deserve, then you can be severely hurt.
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congratulations lab rat, looks like you have discovered that abscence of evidence of harm is not evidence of the abscence of harm.
sounds like vasoconstriction, perhaps due to alpha adrenergic activity of the hydroxy metabolite, and if your limbs don't actually die or have to be amputated they will recover eventually.
breathing deeply makes no difference, the tissue oxygen levels are not going to be much effected, because the oxygenated blood is not getting where it should, deep breathing can cause other problems due to hyperventilation.
this drug and its parafluoro relative should be left alone, it appears to have killed at least once and is responsible for hospitalisations in the UK.
just so you know what vasoconstriction caused by RC's looks like:
the toxicology profile of mephedrone at the moment seems very similar to that of PMMA paramethoxymethamphetamine and PMA which has killed scores of people.
I make no apology for posting these images (incidentally they are from a bromodragonfly victim) if it stops one person from dying.
taking these things is always a gamble but the downside risks in this game can be very high, if you treat these things as harmless fun and don't afford them the respect they deserve, then you can be severely hurt.
Really. This is going to happen to me?!!!
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ebola?
Bluelight Crew
vorticies? said:
That beats redosing w/ M1, though, where the first redose might be marginally effective (I seek MDMA-like effects; there are cheaper and better classical stimulants). I wonder why. . .
egor
Bluelighter
Thanks for the reminder of why I wont touch bromo-dragonfly vector
pofacedhoe
Bluelight Crew
never had any urge to touch bromodragonfly but that is pretty minging. as well as all this it is imortant to note that psychiatrists in england want this banned due to increasing incidence of people turning up at hospitals in the grip of psychosis.
yes it feels good but yes it is dangerous
it is pretty worrying how widespread 4-mmc use is becoming in the uk, none of these people who are consuming it on a regular basis in large doses seem to care about the extant history of methcathinone abuse in europe and concomitant problems.
MurphyClox
Bluelighter
Without going further into synthesis discussion (not to piss off the admins) I can tell you that this is not going to work. First, position 4 is not activated in methcathinone, and secondly, there are no feasible direct methylating agents for this job.
Senseless paper-chemistry, as my advisor used to say.
I really can't understand how folks are encouraged to discuss the synth of this awful stuff, if
1. there are far better substances out there, and
2. Vecktor made his point quite visually clear.
Goddamned... ![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
- Murphy
Based on the large number of people who are taking it, I think the negative effects are still small, but quite concerning of course.
It seems to me that some people can handle it very well, while a smaller minority get's quite severe side effects and I wonder why that is.
I know of one guy who did a detailed blood test a couple of month ago, then started using Mephedrone quite heavily and on a recent similar blood test, he only had slightly higher liver values, but otherwise everything was absolutely fine.
He is also a person that can do and did Mephedrone on occasions like 5 times a week with basically no serious side effects.
I know that noone can say for sure, but would it be likely that some people just can handle Mephedrone and never get problems while other people are just very sensitive to it?
For me I have used it on most weekends (so one day per week) in the last 12 month in amounts of 300-600mg over the evening and never had any negative side effects.
No mood problems, no ill after effects, nothing.
I'm also not the person that gets cravings for it and I just use it to party and when I don't go out on a weekend, I don't use it at all.
In regard to the other poster, describing about turning blue, does anyone have an explaination, why he didn't have any problems like that one on his first 3 experiences with Mephedrone?
If it is a metabolic/body issue, should one not expect it to have happen the first time he used it already?
pofacedhoe
Bluelight Crew
it seems that idiosyncratic reactions are where the big problems lie. but i have myself experienced wierd side effects from time to time. the most consistent one being a feeling of lack of breath and a slightly tanned look the day after a binge. these dont sound very promising. unless you watch a lot of laguna bitch on tmf
given the liklihood that if this was promoted by media into a mass panic the use rates would skyrocket (ala mdma in the eighties) , the current climate seems to be one of wait and see. if you are a guinea pig at least restrict use to once every couple of months (do less), and remember its highly addictive
