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1,4butanediol questions

Do you have a dehydrogenase deficiency? Ie. ethnic sensitivity to ethanol?
 
Thank you guys again for all this information. My opinion is that 1,4b does have a psychoactive effect before being metabolized to GHB and I feel it has to do with being an alcohol becaause the effects are similar to alcohol for the first 20-30mins. I have experienced skin breakouts after use along with oily skin. I am not too concerned with that because any amphetamine does the same thing to a much greater extent. The main thing that worries me is the heart palpitations because i have experienced them, however they seemed to subside as one's body gets used to it. Also I believe that GBL is probably just as bad for you and lets face it, drinking solvents is not exactly taking an FDA approved medication. One final thought, the fact that there are few deaths associated with it's use (even compared to GBL) makes me think that short term effects are relatively safe. Long term consistant use is probably a different story. Any other insights/experiences are welcome. If our government will not tell us the relative dangers, we must share our personal experiences and find out ourselves.
 
Are there any dosage regimes for Xyrem(GHB) which could be used for Social Anxiety. I also suffer from oversleeping & get no REM sleep at all, according to a sleep study.

My doctor was open to trying Ketamine, which has helped a bit. He also mentioned GHB as well.

I've read of people who took 2 or 3 small dosages a day, which prevented them from getting tolerant. I don't mind dependence, as long as it actually works. I thought the problem developed a when people start using it day & night, basically a 24/7 regime, get tolerant & dependent then it starts making them feel like shit for the whole day no matter what.

I don't drink alcohol & have never been addicted to anything in my life. So I think I would have the self discipline not to go overboard.

If it is truly the *best* drug for Social Anxiety & you have consistent, legal access to it *&* you have already epic failed over 30 drugs including multiple MAOIs & the last resort treatment Elecroconvulsive therapy...wouldn't it be a good idea to give it a trial?
 
GHB is not a cure for social anxiety. It's too short-acting, euphoric and intoxicating.

Have you tried all the benzodiazepines?
 
Coolio said:
GHB is not a cure for social anxiety. It's too short-acting, euphoric and intoxicating.

Have you tried all the benzodiazepines?
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There are very few things that are. I've tried xanax, klonopin & ativan. Not asking for a cure here. But certain things can reduce symptoms.
 
It worked great for mine, but it really started wearing on me after multiple doses daily for a month or so. I quit cold turkey and the w/d's do suck. 48 hours since last dose and still feel "off-base".
 
GTnV said:
It worked great for mine, but it really started wearing on me after multiple doses daily for a month or so. I quit cold turkey and the w/d's do suck. 48 hours since last dose and still feel "off-base".
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Was that using large amounts of the drug daily? Round the clock? I'm just figuring out whether small amounts would have a helpful effect. It could be everybody is different & that determines whether or not it causes problems as well.
 
Saku39 said:
Was that using large amounts of the drug daily? Round the clock? I'm just figuring out whether small amounts would have a helpful effect. It could be everybody is different & that determines whether or not it causes problems as well.
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I was dosing right when I woke up and having another couple of doses over the 6 hours or so before I had to go to work. I'd go all the way through 8 hours of work without dosing. Then, after work I'd dose 1-2 more times. I was using 2-4ml per dose. I used 4 fl. Oz total over ~ a month.
 
I would be hesitant using 1,4-butanediol for fear of hepatic toxicity. Maybe get a liver panel (ALT/AST...etc) every couple weeks assuming you can afford it or have insurance lol. SWIM has tried GHB but found it to be overly sedating at times, and the dosing curve is extremely steep so be careful.

Saku39 if your doc is open to Ketamine by all means give that a shot my friend. Ket has shown promising results in treating chronic neuropathic pain and other CNS/PNS conditions, including anxiety and depression.

As for benzo's, they lose anxiolytic efficacy rather quickly, some as short as 3-weeks. If you are truly open to anything there is some evidence that deep-brain stimulation or vagus nerve stimulation can help and in some cases lead to lasting remission.

Some ppl also swear by gabapentin as a daily-dosed anxiolytic but it seems to be more effective with generalized anxiety as opposed to social anxiety.

Beta-blockers can be used to treat the physiological symptoms associated with anxiety...sweating, elevated BP/HR etc.

I suffer from anxiety too and after years of trying nearly every pharmacological approach short of MAOI's, the fucked thing is that nothing seems to be a permanent solution.
 
with life comes feelings that we all share, happiness, hate, sadness, anxiety is one of those feelings. Pharm companies want you taking their pills. That is their bottom line, your bottom line is fixing anxiety so do whatever is necessary at the time assuming you're in a stable(ish) state of mind.
 
alkap555 said:
I would be hesitant using 1,4-butanediol for fear of hepatic toxicity. Maybe get a liver panel (ALT/AST...etc) every couple weeks assuming you can afford it or have insurance lol. SWIM has tried GHB but found it to be overly sedating at times, and the dosing curve is extremely steep so be careful.

Saku39 if your doc is open to Ketamine by all means give that a shot my friend. Ket has shown promising results in treating chronic neuropathic pain and other CNS/PNS conditions, including anxiety and depression.

As for benzo's, they lose anxiolytic efficacy rather quickly, some as short as 3-weeks. If you are truly open to anything there is some evidence that deep-brain stimulation or vagus nerve stimulation can help and in some cases lead to lasting remission.

Some ppl also swear by gabapentin as a daily-dosed anxiolytic but it seems to be more effective with generalized anxiety as opposed to social anxiety.

Beta-blockers can be used to treat the physiological symptoms associated with anxiety...sweating, elevated BP/HR etc.

I suffer from anxiety too and after years of trying nearly every pharmacological approach short of MAOI's, the fucked thing is that nothing seems to be a permanent solution.
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I appreciate all the advice. One thing to suggest is trying the MAOI Nardil, it has a better shot of working than just about all other anti-depressants for anxiety. It has side effects like food restrictions, drug interactions, weight gain...but these can be gone just by being careful & exercising right.

If you've already heard it before, I will just reiterate that(in my personal opinion) it's a good idea to try for someone who suffers from Chronic anxiety. This is not just a quick, fleeting suggestion of something that might work. It has the #1 efficacy in Social Anxiety for any drug & is considered the "gold standard" for it(Around 65% I think for Social Phobia people). Its surprising how many people try so many things, but never give it a shot.

In response to Robotussin, we all share a variety of feelings like happiness, anxiety, hate, depression etc. But imagine if someone experienced extreme hate all day, every day, for years. Would that be a healthy, natural thing? No. It would destroy them. I understand that the mindset must be changed, not just the state of the mood. After having so much anxiety & depression for so long, your bound to have an inaccurate view of things, even if your mood goes back to normal.
 
Saku39 said:
Are there any dosage regimes for Xyrem(GHB) which could be used for Social Anxiety. I also suffer from oversleeping & get no REM sleep at all, according to a sleep study.

My doctor was open to trying Ketamine, which has helped a bit. He also mentioned GHB as well.

I've read of people who took 2 or 3 small dosages a day, which prevented them from getting tolerant. I don't mind dependence, as long as it actually works. I thought the problem developed a when people start using it day & night, basically a 24/7 regime, get tolerant & dependent then it starts making them feel like shit for the whole day no matter what.

I don't drink alcohol & have never been addicted to anything in my life. So I think I would have the self discipline not to go overboard.

If it is truly the *best* drug for Social Anxiety & you have consistent, legal access to it *&* you have already epic failed over 30 drugs including multiple MAOIs & the last resort treatment Elecroconvulsive therapy...wouldn't it be a good idea to give it a trial?
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Your doctor gave you ketamine for a sleep issue?!?!?! i cant belive that lol. we need doctors like that here.
 
mr.dopeman said:
Your doctor gave you ketamine for a sleep issue?!?!?! i cant belive that lol. we need doctors like that here.
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No, he gave it for Depression & anxiety. I have already tried essentially every regular antidepressant in existence & done ECT & they didn't work.
 
vy3lo said:
i never ever experienced withdrawal from ghb use and i dosed up to 4 times a day everyday for a year utilizing technical grade lactone and gaba derived lactone to form the sodium oxybate never any withdrawals
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Lucky you. Consider yourself the outlier, though. Message to anyone reading this? Don't think you're gonna react like this guy. You'll definitely get withdrawals.
 
Forgive me for threadjacking...

But what would be the effects of ingesting gamma-hydroxy-butyraldehyde? If I understand correctly, BDO first gets metabolized to this (let's call it GHBA for short) which then gets metabolized to GHB. So if you just directly take the GHBA you would have one less step of metabolization needed to have GHB in your body.

Has anyone anywhere ever experimented with GHBA?
 
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