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Codeine Extraction

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^ Heh, codeine gives me an insomnia. I think that's a listed side effect of opioids as well.

Crankinit: I don't like to combine alcohol with opioids until well after I've dosed, e.g. hours later. Personally I think alcohol ruins the opioid high.
 
^Yeah, although codeine is 'working' for me now, I don't get any great euphoria. It's relaxing though. :)

For those of you who are regular codeine users who are not addicted to codeine, how often do you take it, and how much? I always keep drug use strictly to weekends, I think every fortnight for codeine would be good to keep tolerance down?


Finally, if someone has low CYP2D6 levels, but enough to get a buzz from codeine at ceiling doses, could inhibitors such as promethazine weaken the effects? I understand that the effects would last longer but maybe the promethazine is inhibiting the few enzymes there so the effects are not felt nearly as much as without promethazine?
 
Crankinit: I don't like to combine alcohol with opioids until well after I've dosed, e.g. hours later. Personally I think alcohol ruins the opioid high.
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Yeah I think you're right. I had those two drinks, then another before dosing, and the codeine high felt much weaker. It was there, but dampened significantly by the alcohol.

For those of you who are regular codeine users who are not addicted to codeine, how often do you take it, and how much? I always keep drug use strictly to weekends, I think every fortnight for codeine would be good to keep tolerance down?
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At the moment I take it maybe twice a week, 200 - 350mg. Whenever I'm in the city (usually about once a week) I'll buy a couple boxes of panadeine and usually dose that afternoon, then use the rest a couple days later.
 
^ Promethazine is a CYP2D6 inhibitor; so it could potentially lessen the effects of codeine. One way to counter this is to take the promethazine when you start to feel the high coming on, as the 'potentiation' here isn't a matter of enzyme inhibition, it's the synergistic effect that the sedation and anti-histamine properties of the drug have when combined with codeine.

As for your first question; two weeks is a good schedule for keeping tolerance down. I'm a chipper now, and even using a few days apart gets my tolerance up.
 
^ Promethazine is a CYP2D6 inhibitor; so it could potentially lessen the effects of codeine. One way to counter this is to take the promethazine when you start to feel the high coming on, as the 'potentiation' here isn't a matter of enzyme inhibition, it's the synergistic effect that the sedation and anti-histamine properties of the drug have when combined with codeine.

As for your first question; two weeks is a good schedule for keeping tolerance down. I'm a chipper now, and even using a few days apart gets my tolerance up.
 
^Keep that post count up mate :P

Yeah I had thought that about the promethazine, I guess when the high is coming on it's already passing through the liver so it wouldn't have any effect in that way, only synergistically as you say.
 
^ Add another one to the tally now...

Yeah, the idea of promethazine as a potentiator isn't to inhibit metabolism into less useful substances, but to add sedation to the high and remove unwanted side effects (excessive itching, nausea). Something like cimetidine is a real potentiator, i.e. it increase the blood concentration of the opioid by preventing metabolism therefore technically meaning that less is needed to get the same effect.
 
I don't understand the cimetidine. You say it inhibits metabolism, so the drug stays in the system longer. Isn't this what happens with promethazine? Or is the idea that promethazine is only a weak inhibitor, whereas cimetidine is a strong inhibitor?

Also, codeine is a pro drug so it needs to be metabolised to get the effects. Are you saying it would just last longer?

I can understand this working with, for example, morphine but can't see how it works with codeine, given that it has to metabolised.

EDIT: I just realised it could work if the codeine was still able to be metabolised to morphine, then the cimetidine inhibited the enzyme that was responsible for removing the morphine. But those processes are both handled by CYP2D6, no?
 
Codeine defenately keeps me awake this other stuff was GI-DESIC aka Dextropropoxyphene, we both had 162.5mg of it and 1.625g of paracetamol, basically just knocked us out lol really not that recreational.

The two times i have drunk on codeine has only been 1 beer or so and about an hour and a half after dosing, i feel that it kind of morphes the high into a synergy of the two but the alcohol comes out so much stronger, after 1 beer it feels like i have had at least 4. Might just be me im not sure.
 
It wouldn't be advised mate, for a not so great high the strain you are putting on your liver through the paracetamol is not worth it, just do a quick wash and it will be fine.
 
blah_blah1991 said:
It wouldn't be advised mate, for a not so great high the strain you are putting on your liver through the paracetamol is not worth it, just do a quick wash and it will be fine.
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Damn too late i ate it haha

I had 6 last time was ok. Just feel a bit of heavyness and tiny cramps? in my shoulders but feel all nice n fuzzy. Im just using it as my sunday relaxing haha
 
blah_blah1991 said:
It wouldn't be advised mate, for a not so great high the strain you are putting on your liver through the paracetamol is not worth it, just do a quick wash and it will be fine.
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Considering there's no paracetamol in Nurofen + I wonder how much of your post should be taken with a grain of salt....... :\

Ibuprofen maybe???? :)
 
Crankinit said:
Just up the dose and do an extraction, you're putting a strain on your body for what will probably be a barely noticeable high anyway.
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I tried the CWE last time on bout 10 pills n didnt feel a dam thing off of em. Maybe i did it incorectly. How many mgs would be needed to acheive a "woow, this is cool" effect?
 
Hahahahahaha, my bad.

But yeah it's still not good for the liver or stomach in that case.

Next sunday just do an extraction.
 
Sustanon said:
I tried the CWE last time on bout 10 pills n didnt feel a dam thing off of em. Maybe i did it incorectly. How many mgs would be needed to acheive a "woow, this is cool" effect?
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You probably won't get a 'wow, this is cool' effect. There's no massive euphoric rush with codeine, just a warm, relaxed, comfortable carefree kind of glow. If you have no tolerance I'd say 200mg would be a good starting dose.
 
blau1005 said:
I don't understand the cimetidine. You say it inhibits metabolism, so the drug stays in the system longer. Isn't this what happens with promethazine? Or is the idea that promethazine is only a weak inhibitor, whereas cimetidine is a strong inhibitor?

Also, codeine is a pro drug so it needs to be metabolised to get the effects. Are you saying it would just last longer?

I can understand this working with, for example, morphine but can't see how it works with codeine, given that it has to metabolised.

EDIT: I just realised it could work if the codeine was still able to be metabolised to morphine, then the cimetidine inhibited the enzyme that was responsible for removing the morphine. But those processes are both handled by CYP2D6, no?
Click to expand...

Any answer to this?
 
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